<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10975

Description Metacaspase
SequenceMPRKKALIIGINYYGSEHELSGCINDAMNVREYLVNDRGFSSSSHDMVVMTDAPENQGTPFYPTGANMLAAFEWLTGYNDAGDTVWLSYSGHGGQVADTDGDAPSGFDDTICPVDFEENGQITSDTLHRTLVSPMNPQSRLTILFDCCHSGSACELPFVFRPDEDGNVNLMDTFKKGAGLVRAAEHLLQGGFSMTKVNDAEMLLGGATDFFNSLHHLRGGGADGEGLAEDGYAKEWETEGKDVWMFSGCADDQTSADTSIAGRATGAMSWAFIGTMRENPEQSYRNVLQNTRASLMNNYSQVPQLSCGGHFDLDEQLVVAEKEPQVKQVLDPGPDPASTEATVEDSGLSLTDISTDREERLIAEILANFRNLVMLATEPIGSTASAGQAAYSAMAMEIETKGLIKSAEDLLQLTRLLRELWIIGPLRKPGEGEREAEVTIGEEVRGVVGILNQMREKSRQDLVSQGTGQAVLGQGSYTTSGSEPKGDAAQAQSGTR
Length496
PositionHead
OrganismConiochaeta ligniaria NRRL 30616
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Coniochaetales> Coniochaetaceae> Coniochaeta.
Aromaticity0.07
Grand average of hydropathy-0.380
Instability index33.04
Isoelectric point4.48
Molecular weight53496.78
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
cysteine-type peptidase activity	GO:0008234	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
apoptotic process	GO:0006915	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10975
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.44|      16|      27|     186|     210|       1
---------------------------------------------------------------------------
  186-  209 (19.79/34.02)	HLLQGGFSmtkvnDAEmllGGATD
  215-  230 (31.65/16.10)	HHLRGGGA.....DGE...GLAED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     326.71|      82|     159|      71|     156|       2
---------------------------------------------------------------------------
   71-  156 (144.31/90.77)	AFEWLTgyndAGDTVWLSYSG.HGGQV.A...DTD..GDAPSGFDDTICPVDFEENG....QITSDTLHRTLVSPMNPQSRLTILFDCCHSGSACEL
  233-  313 (119.94/66.94)	AKEWET....EGKDVWM.FSGcADDQTsA...DTSiaGRATGAMSWAFIGTMRENPE....QSYRNVLQNTRASLMNNYSQVPQL..SC..GGHFDL
  317-  382 (62.47/30.59)	................LVVAE.KEPQV.KqvlD.P..GPDPASTEATV.....EDSGlsltDISTDREER.LIAEILANFRNLVMLATEPIGS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.22|      20|      26|       1|      20|       3
---------------------------------------------------------------------------
    1-   20 (34.44/23.94)	MPRKKALIIGINYYGSEHEL
   28-   47 (34.77/24.24)	MNVREYLVNDRGFSSSSHDM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10975 with Med22 domain of Kingdom Fungi
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