<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10973

Description Uncharacterized protein
SequenceMTSRPPLGVQQRQPQRSLSASGLTQRPAHQRTLSQQHLPPSPIRKETTFGDFGGSQSDAGDASQSRYAVQQRRGGSRLKLELSHDSSDSITQMAISESPNALEPSKPFTPSRMMLSMDTPDLGDMSPHASSRAPTADGDAAPMPMPPRRPRFALAVPRAGPTAAPIATIVKKDTRPKPYTVEIPAAAPRFKVHAKPEVLPKPGSQGFGASTTATPITTGFADFYPWTGDHAEDQFSEHVIRHGFFDKAPVASSETSSAKGALFPMLKHKSGLHALSTIFTNVLGHRRHNGQITAPSTFKPPPRVTVTDTKREIWLKDLANPVISLRRLSRTIPHGIRGKVLLDQCLNKNVPIDRAIWLAKCVGANDIRAFKRKGVNGTFVMGGEAKWIRDWTVCVEQFVEAVFSAFGDIEWKAKVNYAVRLATHIYADYLLDRDHYMDWLLDSLEKSTQAKLPVWVLIVQIYWKDMLRLRRTARKLVTVLLHHLHEIQNNPDKDILSPLSSRVTLLLSALMVLSPPSFVSPGSWFKYRDTLLANIPAEDEQRQKIYGLIDARNEQLVASCNKTPPAARQILVKTLDATLQNPMSDDMPRICWDITKDKPNLVRTLLEWCTSMYRPGVAKVYVASRILQAWSTRGVDATAAVLDFLDSDIVEQQARKTAFYHLVCQLTRSGHFSIPRYIQWLIARGGVLASTDVSPDGPCATRLLVELPTHSLSTSQRSMRANMLRRASFYVEDEAQDHDVAIKCLKHSLGMPVDVDDPALPRKPLPISKLAKRIALSNFALKADVGSWLQSSLLASFEEATKDGSHPLEISPTTFNAIRTVFEAAEDLSMLAGVLKSVSSVSNVEILASCADTVSRHILTFAALDVARSLFDTLYVRLRTTAEEQGIGARPLLASLACLAGRMPEKQGIAAQLKKDLVQADRNNPVDACSPVSDNMGARFQDDDADLQEEIEKNLMSGTILDRATMNRLFEAVVMRLNTWWGNHAEKQRRYGMLLARLRGFDQQHFDSLIAKWILHLRSITNRPSILRMFPLLIGVGCLNFPLLLASTYVEQPVVPGAGTSRSAPTTSSGSVQTIQLTYRTRYCQEVLGMVTKPLTPDDLLSQEECYRIAIMQDQALKDNSNEILALVRQALAEYSLCRDKGDTDALPLDDTVEREHLIDMLRSLVLRDCPGVIKALSPRSSDPHVGKWIDCMATKLLIPTAVEGTQVTFDQILELTNEFTLSFCQLKISLSLSLADQNSPDAAERIQTHLDLFTKAMDNAIDAENTSWTGMLSSLSPEITHHLKSRAQTRFLELLPSLRTPPPSDATLEQSLQTAENFLSVIDAIIRGGSMGRSPQLVPAMVDKLVDIWEVLSSPSTDLGGKNAVLNHWLPALLSLITLHTSTFDSSKAGFEVRARTVIVLSGLLQELSVMPPSMVIAATNCSSPRNTPQVTLANRIFDLACLLIDNLNDEVRNQCLRVVNASADARLRYIFSFARNPAEHLMLSHKDKTGPANTAGGRPQVGPGHLLGTPASLWAQTVQGPERLTVFHFRRWEMLNEPTPNVGENDTALSLGLFEARKVL
Length1562
PositionKinase
OrganismConiochaeta ligniaria NRRL 30616
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Coniochaetales> Coniochaetaceae> Coniochaeta.
Aromaticity0.06
Grand average of hydropathy-0.192
Instability index45.94
Isoelectric point8.57
Molecular weight172663.09
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10973
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.97|      54|      96|     848|     901|       1
---------------------------------------------------------------------------
  848-  901 (89.84/41.20)	ASCADTVSRHILTFAALDVA..RSLFDTLYVR....LRT....TAEEQGI.GARPLLASLACLAG
  945- 1000 (69.05/30.34)	ADLQEEIEKNLMSGTILDRAtmNRLFEAVVMR....LNTwwgnHAEKQ.....RRYGMLLARLRG
 1001- 1039 (32.07/11.01)	.............F.....D..QQHFDSLIAKwilhLRS....ITNRPSIlRMFPLLIGVGCL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.20|      18|      19|      93|     111|       5
---------------------------------------------------------------------------
   93-  111 (28.41/17.28)	MAIS.ESPNaLEPSKPFTPS
  113-  131 (27.79/12.65)	MMLSmDTPD.LGDMSPHASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.73|      10|      21|     134|     143|       6
---------------------------------------------------------------------------
  134-  143 (19.94/ 8.99)	PTADGDAAPM
  157-  166 (19.79/ 8.87)	PRAGPTAAPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.00|      25|     140|     565|     589|      13
---------------------------------------------------------------------------
  565-  589 (44.32/27.90)	PAARQILVKTLDATL...QNPMSDDMPR
  698-  725 (39.68/24.15)	PCATRLLVELPTHSLstsQRSMRANMLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10973 with Med12 domain of Kingdom Fungi
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