<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10972

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAGDYDTNTLLVNNLSSIAFKIYEPVVSQSSVYTFNASDVEFALRNDGHLVYMDVVRRGIWCFYLVKKDPTGTATSSEQSRLGPTLEVCGYQLGLVGEGAFEPISLQKSRPPGTNPINTPSSSSSNTSTLEASARSGTSFNLPSAGSMASGAMDLDSRAAPPVLGPDPKGYGSVPVKDMHEFFIMAILSSLSTAFCRCSGALSLTPRTLLLPPNTLRPNDSEPVRYPPLSALATFRVYLTTTGSLVISLSVSAMEGLISSSDALRSDWYSAGTPVLAAPLGAFASLQSVLNKDHLLSDNASVQSPETQISRFRPEVADKLSQWRSHLSKLLQLRGISPSILDGCSWVNIQFLKKKPYEYKADGKRTPMTSPAPIVSWPSVLCFRKPSGSMLLHDLGLEKALIGNDGDFDPLDNAKSWFESNPEREELFSKRRKKEQQESAMRETGTADGLQQPRNDASPLTLRRISNAGAAAAAAAAGAMYPTPPDGVQQPPGVTPSFDVAMSSPPNQSVTAVAVSSDPITIGEGRQTRSLSGGWEGDVKREQSDTTFPEGENLFGDLGGEDLFENNELTDADFSFFDQDTGDNGLDLAGLPGMDDAMDLSPTLDHTGVGHSHGSMVATDTQPKEPVSPVFAKPELKHARSTLAEESRHPISSANAHEVAATGIKRQLSPFDPDTVYKRVRASFSGPPAIKHFVADKSTSRRGSVFEKVDFDPSLSLTNKKYGENGQFRYTLPSQEETEEASSHKPTAAAVPSIQQRRRKDLKELPANSRFGELIAKITAGLENNSLDNSPTKNDGPFSDRDDLSLVSDQDDDSVMTDEPNSPTKYSAMRRPVDDDNMSLAASFRDLDQHSTAESPAYAMADLSRLSQPGTPELPVTKYFADTEPWPLQLSCRDDDFITIAQVLTEQAVSGSLRLGPKNTADMEIQETRRNVLNATRHSMQCLRSVLPSSLTTAAECQFRPFIEIQDVPLLGQPSRMQPRPVGQGMILPNLFQIPAPHVELRRYESKLSVLPSAVSFWESLGLSPSQGAKDINAICVFPNWKGMQDNVVCFLDRIRSIYESLKMGTFDRLLYGTDIPSGLFPYNVDKASASPFSATGPQPSSALSAAMTKLANDLARFIVTEKNHVVYFVYSPENPGSIVEACAAFQDLFEKYKKAVADRKKTISNELVLQLIPLDHVASETTVAILSPSEYIQLCIETYDRCTVFGGPMPAPAIVLEPSLPRMIEFKPNASPSANVLHENSCIHIAYARSVDERWITAAWTDNRGIKQMTASYCLGRRGKPLSNPLEEVTREIWDTTHDLISMWKVHWRVVITKCGPMEQSEIENWMVLAQGETKASISLTLMTVDTNPSLQLIPPAAKIPVTMSSAFYTTPVSTPQPMTTVSPEQSGNPPTPMGVGNPMNATTPGGENSATEPEADTTLIDVTDTTWGAVVSHRLNNSSSLTELNPAVQSGYLVKRSGVRPEDPPVAMEVNVIHSEGNNPRAYEAVLREMLMYFRGLGTLARLRGVVDRETDVRPWHVAAAEKGVRALYQLL
Length1535
PositionKinase
OrganismConiochaeta ligniaria NRRL 30616
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Coniochaetales> Coniochaetaceae> Coniochaeta.
Aromaticity0.07
Grand average of hydropathy-0.342
Instability index51.15
Isoelectric point5.24
Molecular weight167166.37
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10972
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     359.16|     116|     128|     304|     429|       1
---------------------------------------------------------------------------
  304-  429 (184.06/131.68)	QSPETQISRFRP.EVADKLSQWRSHLSKlLQLRGISPSildGCSWVNIQflKKKPYEYKADG.KRTPMTSPA...PIVSWP..SVLCFRKPSGSMLLHDLGLEKALIGN.DGDFDPlDNAKSWFesnPEREELF
  433-  556 (175.10/100.39)	RKKEQQESAMREtGTADGLQQPRNDASP.LTLRRISNA...GAAAAAAA..AGAMYPTPPDGvQQPPGVTPSfdvAMSSPPnqSVTAVAVSSDPITIGEGRQTRSLSGGwEGDVKR.EQSDTTF...PEGENLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.50|      32|      38|     639|     674|       2
---------------------------------------------------------------------------
  643-  674 (56.53/36.59)	TLAEESRHPISSANA..HEVAATGIKRQLS.....PFDP
  676-  714 (45.97/20.24)	TVYKRVRASFSGPPAikHFVADKSTSRRGSvfekvDFDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.57|      26|      49|     215|     240|       3
---------------------------------------------------------------------------
  215-  240 (46.85/29.86)	NTLRPN...DSEPVRYPPLSALATFRVYL
  263-  291 (37.72/22.30)	DALRSDwysAGTPVLAAPLGAFASLQSVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.60|      30|      63|     886|     919|       4
---------------------------------------------------------------------------
  886-  919 (49.87/41.09)	PWPLQLS..CRDDDFITIAQV.LTEQAVsgslRLGPK
  949-  981 (46.73/28.75)	PSSLTTAaeCQFRPFIEIQDVpLLGQPS....RMQPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.59|      27|     300|     772|     798|       5
---------------------------------------------------------------------------
  772-  797 (38.51/22.88)	.....F....GELIAKITAGLENNSL..D..NSPTKNDG
  798-  829 (26.85/13.44)	P.....fsdrDDL..SLVSDQDDDSVmtDepNSPTKYSA
  833-  857 (25.24/12.14)	PvdddN....MSLAASFR.DLDQHST..A..ESP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.77|      39|      47|      70|     113|       6
---------------------------------------------------------------------------
   70-  113 (62.48/37.87)	DP..TGTATSSEQSrlgpTLEV...CG..YQLGLVGEGAFEPISLQkSR..PP
  116-  163 (52.29/21.67)	NPinTPSSSSSNTS....TLEAsarSGtsFNLPSAGSMASGAMDLD.SRaaPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.29|      21|     130|    1058|    1078|       7
---------------------------------------------------------------------------
 1058- 1078 (38.58/24.86)	SIYESLKMGTFDR.LLYGTDIP
 1191- 1212 (36.71/23.30)	SEYIQLCIETYDRcTVFGGPMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.43|      21|      24|    1373|    1393|       8
---------------------------------------------------------------------------
 1373- 1393 (41.01/19.75)	TPVSTPQPMTTVSP..EQSGNPP
 1394- 1416 (35.42/16.06)	TPMGVGNPMNATTPggENSATEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.07|      23|      24|     561|     583|       9
---------------------------------------------------------------------------
  561-  583 (42.15/26.62)	GEDLFENNELTDA.DFSFFDQDTG
  586-  609 (37.92/23.14)	GLDLAGLPGMDDAmDLSPTLDHTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10972 with Med13 domain of Kingdom Fungi
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