<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10972

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAGDYDTNTLLVNNLSSIAFKIYEPVVSQSSVYTFNASDVEFALRNDGHLVYMDVVRRGIWCFYLVKKDPTGTATSSEQSRLGPTLEVCGYQLGLVGEGAFEPISLQKSRPPGTNPINTPSSSSSNTSTLEASARSGTSFNLPSAGSMASGAMDLDSRAAPPVLGPDPKGYGSVPVKDMHEFFIMAILSSLSTAFCRCSGALSLTPRTLLLPPNTLRPNDSEPVRYPPLSALATFRVYLTTTGSLVISLSVSAMEGLISSSDALRSDWYSAGTPVLAAPLGAFASLQSVLNKDHLLSDNASVQSPETQISRFRPEVADKLSQWRSHLSKLLQLRGISPSILDGCSWVNIQFLKKKPYEYKADGKRTPMTSPAPIVSWPSVLCFRKPSGSMLLHDLGLEKALIGNDGDFDPLDNAKSWFESNPEREELFSKRRKKEQQESAMRETGTADGLQQPRNDASPLTLRRISNAGAAAAAAAAGAMYPTPPDGVQQPPGVTPSFDVAMSSPPNQSVTAVAVSSDPITIGEGRQTRSLSGGWEGDVKREQSDTTFPEGENLFGDLGGEDLFENNELTDADFSFFDQDTGDNGLDLAGLPGMDDAMDLSPTLDHTGVGHSHGSMVATDTQPKEPVSPVFAKPELKHARSTLAEESRHPISSANAHEVAATGIKRQLSPFDPDTVYKRVRASFSGPPAIKHFVADKSTSRRGSVFEKVDFDPSLSLTNKKYGENGQFRYTLPSQEETEEASSHKPTAAAVPSIQQRRRKDLKELPANSRFGELIAKITAGLENNSLDNSPTKNDGPFSDRDDLSLVSDQDDDSVMTDEPNSPTKYSAMRRPVDDDNMSLAASFRDLDQHSTAESPAYAMADLSRLSQPGTPELPVTKYFADTEPWPLQLSCRDDDFITIAQVLTEQAVSGSLRLGPKNTADMEIQETRRNVLNATRHSMQCLRSVLPSSLTTAAECQFRPFIEIQDVPLLGQPSRMQPRPVGQGMILPNLFQIPAPHVELRRYESKLSVLPSAVSFWESLGLSPSQGAKDINAICVFPNWKGMQDNVVCFLDRIRSIYESLKMGTFDRLLYGTDIPSGLFPYNVDKASASPFSATGPQPSSALSAAMTKLANDLARFIVTEKNHVVYFVYSPENPGSIVEACAAFQDLFEKYKKAVADRKKTISNELVLQLIPLDHVASETTVAILSPSEYIQLCIETYDRCTVFGGPMPAPAIVLEPSLPRMIEFKPNASPSANVLHENSCIHIAYARSVDERWITAAWTDNRGIKQMTASYCLGRRGKPLSNPLEEVTREIWDTTHDLISMWKVHWRVVITKCGPMEQSEIENWMVLAQGETKASISLTLMTVDTNPSLQLIPPAAKIPVTMSSAFYTTPVSTPQPMTTVSPEQSGNPPTPMGVGNPMNATTPGGENSATEPEADTTLIDVTDTTWGAVVSHRLNNSSSLTELNPAVQSGYLVKRSGVRPEDPPVAMEVNVIHSEGNNPRAYEAVLREMLMYFRGLGTLARLRGVVDRETDVRPWHVAAAEKGVRALYQLL
Length1535
PositionKinase
OrganismConiochaeta ligniaria NRRL 30616
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Coniochaetales> Coniochaetaceae> Coniochaeta.
Aromaticity0.07
Grand average of hydropathy-0.342
Instability index51.15
Isoelectric point5.24
Molecular weight167166.37
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10972
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     359.16|     116|     128|     304|     429|       1
---------------------------------------------------------------------------
  304-  429 (184.06/131.68)	QSPETQISRFRP.EVADKLSQWRSHLSKlLQLRGISPSildGCSWVNIQflKKKPYEYKADG.KRTPMTSPA...PIVSWP..SVLCFRKPSGSMLLHDLGLEKALIGN.DGDFDPlDNAKSWFesnPEREELF
  433-  556 (175.10/100.39)	RKKEQQESAMREtGTADGLQQPRNDASP.LTLRRISNA...GAAAAAAA..AGAMYPTPPDGvQQPPGVTPSfdvAMSSPPnqSVTAVAVSSDPITIGEGRQTRSLSGGwEGDVKR.EQSDTTF...PEGENLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.50|      32|      38|     639|     674|       2
---------------------------------------------------------------------------
  643-  674 (56.53/36.59)	TLAEESRHPISSANA..HEVAATGIKRQLS.....PFDP
  676-  714 (45.97/20.24)	TVYKRVRASFSGPPAikHFVADKSTSRRGSvfekvDFDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.57|      26|      49|     215|     240|       3
---------------------------------------------------------------------------
  215-  240 (46.85/29.86)	NTLRPN...DSEPVRYPPLSALATFRVYL
  263-  291 (37.72/22.30)	DALRSDwysAGTPVLAAPLGAFASLQSVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.60|      30|      63|     886|     919|       4
---------------------------------------------------------------------------
  886-  919 (49.87/41.09)	PWPLQLS..CRDDDFITIAQV.LTEQAVsgslRLGPK
  949-  981 (46.73/28.75)	PSSLTTAaeCQFRPFIEIQDVpLLGQPS....RMQPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.59|      27|     300|     772|     798|       5
---------------------------------------------------------------------------
  772-  797 (38.51/22.88)	.....F....GELIAKITAGLENNSL..D..NSPTKNDG
  798-  829 (26.85/13.44)	P.....fsdrDDL..SLVSDQDDDSVmtDepNSPTKYSA
  833-  857 (25.24/12.14)	PvdddN....MSLAASFR.DLDQHST..A..ESP.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.77|      39|      47|      70|     113|       6
---------------------------------------------------------------------------
   70-  113 (62.48/37.87)	DP..TGTATSSEQSrlgpTLEV...CG..YQLGLVGEGAFEPISLQkSR..PP
  116-  163 (52.29/21.67)	NPinTPSSSSSNTS....TLEAsarSGtsFNLPSAGSMASGAMDLD.SRaaPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.29|      21|     130|    1058|    1078|       7
---------------------------------------------------------------------------
 1058- 1078 (38.58/24.86)	SIYESLKMGTFDR.LLYGTDIP
 1191- 1212 (36.71/23.30)	SEYIQLCIETYDRcTVFGGPMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.43|      21|      24|    1373|    1393|       8
---------------------------------------------------------------------------
 1373- 1393 (41.01/19.75)	TPVSTPQPMTTVSP..EQSGNPP
 1394- 1416 (35.42/16.06)	TPMGVGNPMNATTPggENSATEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.07|      23|      24|     561|     583|       9
---------------------------------------------------------------------------
  561-  583 (42.15/26.62)	GEDLFENNELTDA.DFSFFDQDTG
  586-  609 (37.92/23.14)	GLDLAGLPGMDDAmDLSPTLDHTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10972 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAGAMYPTPPDGVQQPPGVTPSFDVAMSSPPNQSVTAVAVSSDPITIGEGRQTRSLSGGWEGDVKREQSDTTFPEGENLFGDLGGEDLF
2) AGLENNSLDNSPTKNDGPFSDRDDLSLVSDQDDDSVMTDEPNSPTKYSAMRRPVDD
3) ESNPEREELFSKRRKKEQQESAMRETGTADGLQQPRNDASPLTLRRISNA
4) ISLQKSRPPGTNPINTPSSSSSNTSTLEASARS
5) LTDADFSFFDQDTGDNGLDLAGLPGMDDAMDLSPTLDHTGVGHSHGSMVATDTQPKEPVSPVFAKPELKHARSTLAEESRHPISSANAHEVAATGIKRQL
6) SSAFYTTPVSTPQPMTTVSPEQSGNPPTPMGVGNPMNATTPGGENSATEPEADTTLIDVT
7) YGENGQFRYTLPSQEETEEASSHKPTAAAVPSIQQRRRKDLKELP
474
781
420
105
570
1367
723
565
836
469
137
669
1426
767










Molecular Recognition Features






MoRF SequenceStartStop




1) DLFENNELTDADFSFF
2) TLRRI
3) VYKRVR
563
462
677
578
466
682