<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10909

Description Mediator of rna polymerase ii transcription subunit 15a
SequenceMDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMPSTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQQPQDQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQQQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQSQRAAPEASSTSLDSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVSTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQHQIYHRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKNGTPLQSTSSPFVVPSPSTPLAPSPMPGDSEKVSTGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGPTGTKKMKRYTTSNVVSSSGSVNDSFWQLNCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDEGVDPSAVAAATEGGEGTTVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSASLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1354
PositionTail
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.773
Instability index71.94
Isoelectric point9.38
Molecular weight148961.97
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10909
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     938.00|      86|      86|     231|     316|       1
---------------------------------------------------------------------------
   59-  146 (54.53/ 6.61)	.............................RHLPV.S...G..QEGVQelkkiavrfeekiytA...A..TSQQdYL..RKISLKMltMETKSQ...NPI.N..NS.MQPNAASSGQ..NALGPGSHSMQSQV...NSQAQQ.L
  149-  219 (82.81/14.95)	PMVAN..................QT.Q.TRQPLL.....Q..QNIQN...............N...M..PSTG.L....Q.NSAS..LTPALPP..VSNlT..QA.TMPNVMGQNA..NLQTMQN..........MQNVGQNS
  231-  316 (159.85/37.66)	NMVANS...............QRQM.Q.GRQQVV.S...Q..QQQQQ...............S...Q..TSQQ.YLYQQQMHHQM..MKQKFQP..GST.Q..QS.MMQSHMQQQQ..QQQQPQDQQQQQQQ...QQQQQQNL
  321-  413 (88.99/16.77)	QIQSSQ...............QTMM.QpSSMQST.SlsnL..QQNQQ...............StvqQ..STQS.VLHQRS..QSV..MRQQQAP..MLH.Q..Q....QSAMLQQPilPAQQHQQQQQQQQQliaQQANATNL
  416-  485 (91.40/17.48)	NQLIGQ...............QNTM.P.DVQQRI.V...G..QQNNY...............S...S..LQQQ.QLLNQQNNLQN..MHQQ.QL..GS..........QSNIAGVQ..QQQLT............GSQQPGNS
  495-  578 (81.50/14.56)	HMLQQS...........kvplQQQMlQ.GGTTLLpS...Q..GQQSQ...............S...Q..PA......QQQM...M..SQSQSQPplGLQ.Q..QTnQLQREMQQRL..QTSGPLLQQQNVME...QQKQ...L
  582-  662 (73.60/12.24)	QRAAPE...............AS...S.TSLDST.A...Q..TGNAN...............A...A..DLQE.EVYQK...IKS..MREMYLP..ELN.DlyQK.IAAKVQQHDS..LPQRPQ..TEQIEK...LKVFKMTL
  663-  734 (72.22/11.83)	ERVVVF...............LR...L.NKHDIQ.P...S..HKEK.............................LLQVEKHISF..FLNSNRP..RKP.T..PP.LQGQLPQPSM..QLQQPQSLDGQGNP...PMQP....
  735-  810 (82.22/14.78)	..VQGS...............MAAM.Q..QNNIT.N...L..QHNSL...............S...G..VST...ISNSQQH.....MVNTVQS..GST.V..D..LGQGN.SLNS..LQQVATGSLQQNPV...NSPQQVNI
  812-  885 (92.91/17.93)	SL..NS...............Q....S.GTNPVQ.A...NlgSLQPN...............S...N..VLQQ.SLPKQ..HEQQ..MLQ..........N..QQ.LRQQYHQRQM..QHQIYHRQQFMQQQ...QAKQQQTA
  886-  963 (57.96/ 7.63)	QLPAHQmsqlhqmndandlkmRQQM...GLKPGV.L...Q..QQQSV...............G...QrvGSH................HPQLKP..GIS.S..PQ.IHQALSPQVT..QHPSPQIDQQN..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.26|      14|      27|    1061|    1074|       2
---------------------------------------------------------------------------
 1061- 1074 (23.20/13.82)	VSGKSSVEQPLERL
 1090- 1103 (18.97/ 9.84)	VSDISSVVSMIDRI
 1154- 1167 (21.09/11.84)	VSSSGSVNDSFWQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.71|      12|      15|     988|     999|       3
---------------------------------------------------------------------------
  988-  999 (23.65/12.33)	STPLAPSPMPGD
 1004- 1015 (17.06/ 6.42)	STGLALHTTAGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.71|      22|      47|    1243|    1264|       4
---------------------------------------------------------------------------
 1243- 1264 (38.77/21.16)	LSPNLKSQYASAQMSPIQPLRL
 1292- 1313 (36.94/19.77)	LSMKAKSRFSASLRSLSQPMTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10909 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMPSTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) MDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDS
3) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVSTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQHQIYHRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKNGTPLQSTSSPFVVPSPSTPLAPSPMPGDSEKVSTGLALHTTAGNIMHQQATVASAPAQSL
4) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQSQRAAPEASSTSLDSTAQTGNANAADLQEEV
5) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQQPQDQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQQQQQQLIAQQ
97
1
692
441
257
252
45
1031
611
407










Molecular Recognition Features






MoRF SequenceStartStop




NANANA