<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10907

Description Mediator of rna polymerase ii transcription subunit 12
SequenceMQRYHGGSCTSAVNNSTIGGSSARDSSRVESASLPPNFSRRPFQLTPYKLKCDKEHLNSRLGPPDFLPQTPNCPEETLTKEYVQSGYRETVEGLEEAREISLSQVQAFTKPVIFKCKEAIRKCHRAINESRAQKRKAGQVYGVPLEGSQLTKPGTFPDQRSCGEEFRKKWIEGLSQQHKRLRSLADHVPHGYRRKSLFEVLIRNNVPLLRATWFVKVTYLNQVRPGSSSMSSGVPDKTHISRSEQWTKDVIDYLQYLLDEFISRNSVHSALHIRDRSPQMGYAGSIQLKSDPTLGTIDCEEPSLHFKWWYVMRILQWHQREGLLIPSLIIDWVLNQLQEKELLGVLQLLLPVIYGFIDTVVLSQSYVRTLVGIAIRFIQEPSPGGSDLVDNSRRAYTMAALVEMLRYLMLAVPDTFVALDCFPMPPCVMTNVVTDGSLYSKVTEDARKVKNGPFEVAYFLRDKGPEVRSDSYSISRVVSSIQKRAQNLAMAARPGHPGQNVAKALHALDKALAHGDLREAYKFLLENVHDSSIDDCWFAEVSSCLRSSLKYIRSVTLSSICSVFFICEWATCDFRDFRYAPPRGIKFTGRKDFSAIYIAVRLLKLKMREAGLSSRLREHKIVKNDHLRTDPGQLTNYSGRSPGSGASEPLCYKRRASGKCGDFLGMFDSPSPLHDILVCWIDQHEVQNTEGFKRLQLLIIELIRAGIFYPQAYVRQLIVSGLMDGNGPISDPTKQKRHCKILKHLPGQYVQDALEEARIAESHVLSEVMNVYCNERKLVLHGKIDPCSTTFGSSYHKHKPRPNSGESLSAPSIDQLRSSESGSFRLSKDVGRGAELEELKGSITTLLQLPSSSSTDTGVDESQVSFKKAVVSGSNGMDNSEGTPGCEECRRAKKQKISEEKSSYSQIYPLNPSDDEETWWMRKGQKSIESFRAEPPPKPAKSASRGRQKVVRKTQSLAQLAAARIEGSQGASTSHVCDSKISCPHHRSGIEGIAPKSADGTRMPNGDVVSIGKVLKGLRFMEKRTITVWLIGIVKQLVEESEKNVTKVGQYGRPFSAADERGCVRWKLGEDELSAVLYLIDSCDEFVLAARFLLWLLPKVLGSCSATVHGSRNILTIPKNTENNVCEVGEAYLLSSMRRYESIIVAADLIPETLSVVMRRAQAILTSNGRVSGSPTVIYARYLLKKYGSVGSVTEWEKTVKSTFDKRLASEVESGRLLDGEFGFPLGVPVGVQDPDDYFRQKITGVRVSRVGLSMRDIVQKKVDEAVNYFYGKDRKLFGPNSGKIPGFQKWEDVYQIGQQIVMGLMDCMRQTGGAAQEGDPTLVSSAISAIVCNIGQVIAKIPDLTASNNHLSFSSTSASLHFARCILRIHVICLCILKEALGERQSRVFEVALATETSSALAPVFAPGKAPRSQFQLSPELNDSNASSDILNNSSRVALGRAAKISAAVSALVIGAILQGVASLERMVSLFRLKDGLDVVHFVRSMRSNSNGNARSVGTLKADSLAEVSVHWFRVLVGNCRTVSDGFIVDLLGEASILALCRMQRMLPLNLVFPPAFSMFAFVLWRPLILNSSSGTRDEVQQLHHSLLLGFGDVIKHLPFREVCLRDTHSLYDLIAADTVDSDFASLLEASGVDLRTKASAFVPLRARLFLNALIDCRIPQPIVKQDDGNQVGVQGESKFHGAENETKLLDKLVYILDTLQPAKFHWQWIELRLLLNEQAVIEKLEGHDLSLVEALRSLSPNTDKASVSENESNIIEMILTRLLVRPDAAPLFSEVVHLLGRSLEDSMLLQAKWFLGGHDVLFGRKSVRQRLINIAVSKGLSTRAQYWKPWGWCPSNSDPTTSKGEKFKSEVSSIEEGEVVDEGTTLKRPVKGSGHTVDVEGFLVRQQHVTERALVDLILPCLDQASDDSRSTFASDMIKQMNHIEQQINAVTREASKPAGTVASGIESPTTKSSRKGTRGSSPGLARRASGPAETVPPSPVALRASLSLRLQFILRLFPIIYADREPSGRNMRYMLASVILRTLGSRIVHEDASHFFNQAYSSKRELDSLVEASSTASVVMSLESLFDRLLLLLHGLLSSHQPRWLKGRSSSKSSSESSKDYSAFEREGVENLQNELDRMQLPETVRWRIQSAMPILFPSVRWSISCQPPSVAPAALSSLLPSNPISVLHSSNGLNQTQRTPVSLLRTATSVSGKAKHVSSQQENDLEVDPWILLEDGAGSSQSSSNSTLVGGSDNANLKASNWLKGTVRVRRTDLTYIGAVDDDS
Length2268
PositionKinase
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.254
Instability index47.58
Isoelectric point8.91
Molecular weight251179.92
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of development, heterochronic	GO:0040034	IEA:EnsemblPlants
regulation of radial pattern formation	GO:0090213	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10907
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.87|      77|      81|    1424|    1502|       1
---------------------------------------------------------------------------
 1413- 1495 (112.94/80.12)	RSQFQLSpelnDSNASSDIlnNSSRVALGRAAKISAAVSALVIG.AILQGVASLERMVSL.FRLKDGLDVVHFV..RSMRSNSNGNA
 1496- 1577 (112.93/74.10)	RSVGTLK...aDSLAEVSV..HWFRVLVGNCRTVSDGFIVDLLGeASILALCRMQRMLPLnLVFPPAFSMFAFVlwRPLILNSSSGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.91|      58|     363|     289|     371|       5
---------------------------------------------------------------------------
  289-  371 (78.06/102.69)	KSDPTLGTIDCEEPsLHfkwwyvmrilqwhqregllipsLIIDWV.LNQLQEKELLGVLQLLlpVIYGFIDTVVLSQSYVRTLV
  659-  718 (97.85/62.59)	KCGDFLGMFDSPSP.LH.....................dILVCWIdQHEVQNTEGFKRLQLL..IIELIRAGIFYPQAYVRQLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.07|      34|    1586|     208|     246|       6
---------------------------------------------------------------------------
  208-  246 (56.28/47.94)	LLRATWFV...KVTY.LNQVRPG..SSSMSSGVPdkthiSRSEQW
 1790- 1829 (45.79/27.57)	LLQAKWFLgghDVLFgRKSVRQRliNIAVSKGLS.....TRAQYW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10907 with Med12 domain of Kingdom Viridiplantae
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