<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10892

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNGDLEISVDKLPIKRLEFIEEGGAERFPSDIGYDEKTVNLIRRIDFAWAVEREEPKSKKQKKKSSSSSSTSTSSKETSSSNQQPWQWQTLVENLRLAHQELQVIIDLIHTVEANDAVTVAGMTRPKQLPNEHLSDLAVSMATKLQCFRHLGKYFKQSAKALEQQVAREARFYGALIRLQQNWKVKWHRMVAAASGNEGFYLDLFDNSLYDPAVAFRPSSASVVRVEHDPAGMLAVNLPSNSCRTLQFEFLGARAPSGIIKESRTKPKGSFVVSSGETKREKTDDEHVRETHSTLREVHRAIFDEQVFDLVNREAFNPALGVDVTGIQENLLRLSIGQGASLSISLVPSIEDDQTANAVGDEHSETAIVPLESVDASKLDEGKLDFKKLGFPNRISFEIYLQQIFHEHVFIKAKKRLSSLGKTQTSATPTKDGPNLLGHFCVSLAHRIFSNKVLAELESLVSRIPYVQLISHPSWHSRRSSWTLSMKVPDSVLHAGSLSHSSDYVKNVKSHFRTKVMVRDDCISLEGEGAPNVVGLFKGKPDITCPMNRYDCDLSDLPMILLQQVASQVIRWLHEEALMVGIKANRDFLSLSFELEQGETLCLVAHVDPEDLQGCISWWLVMDDGFSEESKLNMDMNNGESETRKFLGYLSLEVLYSTLMDMVSLSSTAGH
Length671
PositionHead
OrganismNicotiana attenuata (Coyote tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.327
Instability index37.20
Isoelectric point5.97
Molecular weight75134.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
production of miRNAs involved in gene silencing by miRNA	GO:0035196	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10892
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.21|      66|      97|      83|     152|       1
---------------------------------------------------------------------------
   83-  152 (106.23/97.69)	QQPW..QWQTLVENlrlAHQELQVIIDLIHTVEANDAV....TVAGMTRPKQLPNEHLS.DLAVSMATKLQcFRHLG
  180-  252 (103.98/80.62)	QQNWkvKWHRMVAA...ASGNEGFYLDLFDNSLYDPAVafrpSSASVVRVEHDPAGMLAvNLPSNSCRTLQ.FEFLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      90.03|      40|     100|     302|     350|       2
---------------------------------------------------------------------------
  302-  329 (38.94/21.51)	..........................................................................IFDEQVF....DLVNREAFNPALGVDVTGIQE
  330-  348 (-5.09/ 9.73)	NLLrlsiGQgasLSISLVP.......................................................................................
  404-  429 (33.95/17.40)	...................sieddqtanavgdehsetaivplesvdaskldegkldfkklgfpnrisfeiylqqIFHEHVF......IKAKKRLSSLGKTQTSATP
  435-  463 (22.24/10.74)	NLL....GH...FCVSLAH......................................................rIFSNKVLaeleSLVSR................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.60|      48|     349|      31|      78|       3
---------------------------------------------------------------------------
   31-   78 (80.59/64.68)	DIG.YDEKTVNLIRRIDFAWAVER..EEPKSKKQKKKSSSSSSTSTSSKET
  380-  430 (74.01/58.72)	DEGkLDFKKLGFPNRISFEIYLQQifHEHVFIKAKKRLSSLGKTQTSATPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10892 with Med17 domain of Kingdom Viridiplantae
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