<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10874

Description "CLUMA_CG017419, isoform A"
SequenceMAPVVQMESQQQQLQVAIPANQGGSISLSMLIDFIVQRTYHDLTVLAELLPRKTDMERKIEIYNFAARTRQLFIRLLALVKWANSASKVDKSALIMNFLEKQSMLFVETADLLTKMARETLVHARLPSFHIPAAVEVLTTGSYNRLPLCIKENLVKPDPIQPQEVDATLGRLNQVIQHRLVTSNLLPQMRKFKIEKGRVTFNVPNEFSVSLTMMGDGDVPWRLLDIEILVEDKETGDGRTLVHPLQVNYIHELIQRRLVNNQQSALCEVYNCLHYFCQSLQLEVLYTQTLRLCRDRLDDNIHVEEYIIGSKLTVSYWRELSGSKDGSRTEMRYRISLLANASNALAVVHMPSTSLGTKDSETNVREKTELAVKMLSMERLLVHTVYFRSVARLNEIQSEFKSFLKDLDSNLQGTTAILTVPVLYPCLRAEQIHITVDTHTGRYHCHVPKHLDCPIMNDMQTALNSDHSKLPELVTELRFWITKRRCEKTLQHLPAIAKERLPIITSAEHPATKIGRHKMFVQLYRYPNVILIVGLKSKPSNPNEIDYSFYLVYIKRVSIDENSNDDTLLDSGTPATTPASTTSVEVPKMFLRVLTMIEFDTFVSTHGPGTAIVKDLDEDVVGMKRKLSADTSSPPNKQQKTAIPAYFIPELAHVVAMCDEKLPFIAMAQELSKRNIPHSGLQVEAHATSLILNLLSLPSPSEVIFQSPQQTTNENKATKNTEKDAKPTTSDQPQQPQQQQQPQQPKSAQKDRQMLYQTFVTKPIYNALMKRLLSISIRTQFTKPNVTDRSWIVELIFNSTPLPSNHPKEQGNRRAVYFHYEMLPTDLIWKTVDQMLNDWIKIVLLFSLIHDFAELYNCDKYNLKSIVSVKSYSYTHLLLLYGENKEISTNIFWCNEAKQFLMTFIGGNLSINPHSLLNDQLQSHLNTNHSLSQIAHILNETYQPLGSIAKLPTLPQLGVHNPKIPVLTFCIIPQSPTLLRIAFHGTYCLEVRLRGGGLVSIRDGAYSRFDRVNVVMEFSPTQGLKGFLSKYVDENAVYRRRSQSEDDNPPSPIQMDDGPQLFRGPQSPRDPGLRFAAPATPPSTSNPHTPASPHPIGQQQQTHGNQHPNFNMTSPPTHMPHPSPGFMPSSPLNQASPMTAMSPGPSNLAYIQGHSDSPFGAQMSPAAASAWPGSPIPRPSPRPGQSPDHKPQMMPQHQLRILPARSWAGAVPTLLTHEALETLCRPCSLSGIPGPEMSPLERFLGCVFMKRQLQRLLKESNLAITPVEPGVVLFRAEGLQCQVYSNPDHLQSLQIRITPTLPNPQDMKPQYQWNIDDLQILEQFFETKVAAPPYRQASMHSFIKLFGVPPPVLKDLIQIIRLEMKPEQCKSMGLQWNVQLCMRASFTSFPIIPLGTPGIVNTKNKLLIFLDLTRITDQPLQQHPIVVLPIIYEIGTQITQLVERRDLNTPAIIIQAANMQLRKYLEKRGVTTADSTLYAAIHDLLSNLTFQIPGQPNQMPGGPPFMPGPGSVPGQGPGMPNQQMSMQQMVPGQQMNMGPDHSQVMNQQAMGQVMGQPQMNQGYGMGQMSGGPSNE
Length1575
PositionTail
OrganismClunio marinus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Chironomoidea> Chironomidae> Clunio.
Aromaticity0.07
Grand average of hydropathy-0.306
Instability index50.52
Isoelectric point8.55
Molecular weight177091.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10874
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.44|      20|      21|    1519|    1538|       1
---------------------------------------------------------------------------
 1116- 1135 (23.86/ 7.55)	.PTHMPhPSPGF..MPSS.PLNQA
 1519- 1538 (41.44/19.05)	MPNQQM.SMQQM..VPGQ.QMNMG
 1541- 1562 (24.13/ 7.73)	H.SQVM.NQQAMgqVMGQpQMNQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     358.94|     107|     379|     108|     214|       3
---------------------------------------------------------------------------
  108-  181 (102.44/65.07)	..............................................................ETADLLTKMARETL...VHARLPSFHIPAAVEVLTTGSYNRLP.LCIKENLVKPD.PIQ.............................PQEVDAT..LGRLNQV.IQHRLV
  182-  259 (68.06/40.38)	TSNLLPQMRKFKIEKGRVTFNVPNEFSVSLTMM........................................................................................gdgdvpwrlldieilvedketgdgrtlvhPLQVN......YIHEL.IQRRLV
  488-  564 (79.45/48.56)	..............................................................KTLQHLPAIAKERLpiiTSAEHPATKI..GRHKMFVQLY.RYP.NVILIVGLKSK.PSN.............................PNEIDYSfyLVYIKRVsIDENSN
  565-  685 (108.99/69.77)	DDTLLDSGTPATTPASTTSVEVPKMFLRVLTMIefdtfvsthgpgtaivkdldedvvgmkrkLSADTSSPPNKQQ.....KTAIPAYFIPELAHVVAMCD.EKLPfIAMAQELSKRNiPHS.............................GLQVEA.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.13|      13|      21|     952|     971|       4
---------------------------------------------------------------------------
  952-  970 (20.68/22.13)	PTLPQLGVHNpkipvlTFC
  976-  988 (26.46/ 8.93)	PTLLRIAFHG......TYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.35|      17|      20|    1040|    1059|       5
---------------------------------------------------------------------------
 1054- 1075 (27.22/11.42)	QMDDGPqlfrgPQSPRD.P..GLRF
 1076- 1096 (18.13/ 6.52)	AAPATP....pSTSNPHtPasPHPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.16|      16|      19|    1175|    1193|       6
---------------------------------------------------------------------------
 1183- 1200 (25.95/13.50)	PGQS.PDHKPQ........mmPQHQLR
 1203- 1229 (16.20/ 6.49)	PARSwAGAVPTllthealetlCRPCSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.74|      17|      20|    1429|    1445|       8
---------------------------------------------------------------------------
 1429- 1445 (29.22/18.57)	P..IIYEIGTQITQLVERR
 1450- 1468 (24.52/14.39)	PaiIIQAANMQLRKYLEKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.62|      18|      25|     706|     724|       9
---------------------------------------------------------------------------
  706-  724 (26.83/15.88)	QSPQQtTNENKATKNTEKD
  734-  751 (33.78/16.48)	QQPQQ.QQQPQQPKSAQKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.67|      22|     385|     911|     941|      10
---------------------------------------------------------------------------
  455-  476 (38.54/18.09)	IMND.MQTALNSDH..SKLPELVTE
  916-  940 (29.13/23.65)	LLNDqLQSHLNTNHslSQIAHILNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.72|      21|      61|    1295|    1315|      11
---------------------------------------------------------------------------
 1262- 1287 (29.12/12.27)	LAITPVEPgvvlfRAEGLQCQVYSNP
 1295- 1315 (40.60/20.09)	IRITPTLP.....NPQDMKPQYQWNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.76|      70|     583|     752|     844|      13
---------------------------------------------------------------------------
  769-  844 (102.97/107.49)	MKRLLSIsIRTQFtKPNVTDR...SWIVELIFNS..TPLPSNhPkeQGNRRAVYFHYEMLP.TDLIwKTVDQMLNDWIKIVL
 1353- 1428 (109.79/59.27)	LKDLIQI.IRLEM.KPEQCKSmglQWNVQLCMRAsfTSFPII.P..LGTPGIVNTKNKLLIfLDLT.RITDQPLQQHPIVVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.49|      12|      23|     877|     890|      19
---------------------------------------------------------------------------
  877-  890 (15.76/15.74)	LLLLYGENkeISTN
  901-  912 (21.73/13.72)	LMTFIGGN..LSIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.69|      15|      72|     264|     280|      20
---------------------------------------------------------------------------
  266-  280 (31.47/22.73)	LCEVYNCLHYFCQSL
  852-  866 (28.22/13.09)	FAELYNCDKYNLKSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.28|      15|      31|     322|     337|      23
---------------------------------------------------------------------------
  322-  337 (22.58/17.47)	GSKDgSRTEMRYRISL
  356-  370 (25.70/14.59)	GTKD.SETNVREKTEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10874 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FQIPGQPNQMPGGPPFMPGPGSVPGQGPGMPNQQMSMQQMVPGQQMNMGPDHSQVMNQQAMGQVMGQPQMNQGYGMGQMSGGPSNE
2) NAVYRRRSQSEDDNPPSPIQMDDGPQLFRGPQSPRDPGLRFAAPATPPSTSNPHTPASPHPIGQQQQTHGNQHPNFNMTSPPTHMPHPSPGFMPSSPLNQASPMTAMSPGPSNLAYIQGHSDSPFGAQMSPAAASAWPGSPIPRPSPRPGQSPDHKPQMMPQHQLRIL
3) VIFQSPQQTTNENKATKNTEKDAKPTTSDQPQQPQQQQQPQQPKSAQKDR
1490
1035
703
1575
1202
752










Molecular Recognition Features






MoRF SequenceStartStop




NANANA