<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10872

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMNITSMETLALLELYIPEYVKTIKYVPWVFSLIGSALIGLSGILPLIIIPSDAIGKNKEIINPAESKSLKTLLSFAVGGLLGDVFLHLLPETWEYDMKDRNSNDHPSIKSGLWVLSGVLIFTIVEKIFSGYTNADENNPQPKCVEIANCLLRKSGGKMPDGKIGESCAPNGSCDIEDVPNGCFLAEKDKKTREQPKKVAGYLNLLANSIDNFTHGLAVAGSFLVSFRHGVLATFAILLHEIPHEIGDFAILLRAGFSRWDAAKAQLLTATAGILGALVAIGGSGVTSAMEARTSWIMPFTAGGFLHIALVTVLPDLLEEEDRIESLKQFSALILGISVMGALTVMMEEDNSWRSQSFRQSVVNKINEAISSSDLTPKKNTVDMENHVFSKARNKDEYLSFVARLIIHVREMNNKNKNTDGGSNSQSGIQQGQGGQAQGNTGIQDPINALQNLASQGTRNVQPQMMGQQQQGPGMMMGGQNQGVMGQQQVNMPNQGPSMIRPQMNQSQGNIMQPQMNTMNQMQMNQIGPGGGQIKGNVSGINPMNQMVPNQVMGAQTGNIMNQGVPMQPGNQSQINQMMNQAQMNNSGGLMVGANQMNNSGMMGVRGMAPNPMMAVMNSGQQQQQQQMINMQQQAMLRPGNQGPGPFPQVRPQNPPNFLRQSPSPMSVPSPIGLSQSQHNSMVASPAMVPSPQAPMSNQPRVGMQNIMAPSPSGNMNTPGQPQGSDYAQSPMNPHDDQIYREKYNQLTKYKEPLKKVISRVGPENNSEKLTKLKKLLEILSNPEARIPLETLVKCEIVLVNQFGTLKDPGPTSINNPLYDAISNNLQNPLATHTIQRIFKPSLEAWFGPDIKNLPPAKKRRLSSDDQVVPNSNEIPHLLQGEIARLDSKFKISLDQTAHTTGAKSIKLVCCLDDKLLPCVPPIHITIPEDYPITSPITRITEHNTQFLIAVEKALRARISKLPERFSLTHVLETWTLAIRQACNPSSTYVEPTQTSVLMAV
Length1000
PositionTail
OrganismClunio marinus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Chironomoidea> Chironomidae> Clunio.
Aromaticity0.05
Grand average of hydropathy-0.304
Instability index45.03
Isoelectric point8.33
Molecular weight109140.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
metal ion transmembrane transporter activity	GO:0046873	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10872
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     443.68|      48|      48|     498|     545|       1
---------------------------------------------------------------------------
  408-  440 (41.04/14.26)	.VR.....E.......MN.....NKNK.....N.T..DGGSNSQSGIQQ....GQ..........G.GQAQGN...........T
  441-  494 (54.73/21.56)	GIQ....DP.......INalqnlASQG...trNV...QPQM..MGQ.......QQQGP...GmmmG.GQNQG.VMGqqqVNMPNQ
  498-  545 (99.11/45.22)	MIR....PQ.......MN.....QSQG.....NIM..QPQMNTMNQMQM....NQIGP...G...G.GQIKGNVSG...INPMNQ
  546-  562 (32.56/ 9.74)	MV....................................P..............NQV.....M...G.AQ.TGNI........MNQ
  566-  606 (61.43/25.13)	M.Q....PG........N.....QSQI.....N......QM..MNQAQM....NNSGGlmvG...A.NQM..NNSG...MMGVRG
  613-  654 (53.39/20.85)	M......AV.......MN.....SGQQ.....Q.Q..QQQMINMQQQAMlrpgNQ.GP...G...PfPQVR..........PQNP
  657-  714 (49.00/18.50)	FLRqspsPMsvpspigLS.....QSQH.....NSMvaSPAMVPSPQAPM...sNQ..P...R...V.GM..QNIMA...PSPSGN
  715-  764 (52.43/20.33)	MNT....P.........G.....QPQGsdyaqSPM..NPHDDQIYREKY....NQLTK...Y...K.EPLKKVISR...VGPEN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.49|      27|      28|     301|     328|       2
---------------------------------------------------------------------------
  301-  328 (39.68/31.61)	AgGFLHIALVTVLPDLLEEED..RIESLKQ
  331-  359 (40.82/27.01)	A.LILGISVMGALTVMMEEDNswRSQSFRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.81|      30|      45|     779|     810|       3
---------------------------------------------------------------------------
  779-  810 (46.92/33.24)	LSNPEARIPLETLVKceIVLVNQFG.TLKDPGP
  825-  855 (50.89/29.25)	LQNPLATHTIQRIFK..PSLEAWFGpDIKNLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.40|      22|      27|     205|     229|       5
---------------------------------------------------------------------------
  205-  229 (33.64/30.03)	LANSIDNFTHGLavaGSFLVSFRHG
  234-  255 (37.76/25.23)	FAILLHEIPHEI...GDFAILLRAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10872 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNNKNKNTDGGSNSQSGIQQGQGGQAQGNTGIQDPINALQNLASQGTRNVQPQMMGQQQQGPGMMMGGQNQGVMGQQQVNMPNQGPSMIRPQMNQSQGNIMQPQMNTMNQMQMNQIGPGGGQIKGNVSGINPMNQMVPNQVMGAQTGNIMNQGVPMQPGNQSQINQMMNQAQMNNSGGLMVGANQMNNSGMMGVRGMAPNPMMAVMNSGQQQQQQQMINMQQQAMLRPGNQGPGPFPQVRPQNPPNFLRQSPSPMSVPSPIGLSQSQHNSMVASPAMVPSPQAPMSNQPRVGMQNIMAPSPSGNMNTPGQPQGSDYAQSPMNPHDDQIYREKYNQ
411
745










Molecular Recognition Features






MoRF SequenceStartStop




NANANA