<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10863

Description Eukaryotic translation initiation factor 3 subunit K
SequenceMAKLIKTDDGTLMTIPEMLKSIERYNPTHFVFLEQYVQEQAKENTYDLDANLAVLKYYQFNPLALNLNITHLILLKALTNLPFSDFVLCKYLLLPTQMRDDTVKEIIYIADILEQCDFVLFWQTVQNKGALFEKITGFYDSVRKFVCHVVGTTFQTVDKVYLSKLLGNVDDKQLTHWVKKHNWTMQGDIVTIIKQEETIKTKHIAEKIDFESLGGLMANCFSTNNNKMSVEDEVLRIHKKLSKITSSGTDNQTQALDLLKALQNLKIDLDILTSTRIGMAVNELRKCSKDEEVINLSKKLIKNWKKLLASNPESPKSSQKSSNGSSASKPSSKDSNKDDKIKDSKSKSSSQTNFPPPSSSSTTDVVRLKCREMLAGALKVEDYPDGCASAEELAEELEEAIFAEFKNTDMKYKNRIRSRVSNLKDTKNPGLRNNFITGVISASRFAKMTPEEMANDEMKKLREKFVKESINDAQLATVQGTKTDLLKCGKCKKKDCTYNQLQTRSADEPMTTFVMCNACEQGKSMSNYTRMFRGKMRTSTCRIILITSLAWLLIDVIIIMKYTDGLNGGIFKKSRDNGQQSHNVASLSGGHHVIDEDPIVDEEEIDTNLNNIDNGDEIVKRISKTYRTVDLKKWRPAPVVKENPGKPGEMGKPVKMKSYQQEEMKEKFKENQFNLLASDMIWLNRSLSDVRHKDCRTKTYPGKMPTTSIVIVFHNEAWSTLLRTIWSVINRSPRPLLKEIILVDDASEREYLGKKLEDYVQTLPVSTYVLRTGKRSGLIRARLLGAANVKGQVITFLDAHCECTEGWLEPLLSRIVLDRRTVVCPIIDVISDETFEYVTASDQTWGGFNWKLNFRWYRVPSREMSRRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGILEIAPCSRVGHVFRKSTPYTFPGGTSQIVNKNNARLVEVWLDEWKEFYYNINPGARKTSAGDVSGRLQLRERLQCKSFRWYLENIYPESQMPLDYYFLGEIRNAESHNCLDTMGHKSGEKVGSSYCHGLGGNQVFAYTKRQQIMSDDNCLDASNANGPVNLVRCHGMGGNQEWSYDENDLTIKHVNSGNCLTRPTKDDPSTPLLRPCNYSKGQQWLMQSKFKWQSRHGSEDEKRR
Length1157
PositionUnknown
OrganismClunio marinus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Chironomoidea> Chironomidae> Clunio.
Aromaticity0.08
Grand average of hydropathy-0.539
Instability index42.10
Isoelectric point8.66
Molecular weight131976.27
Publications









Function






Annotated function

Component of the eukaryotic translation initiation factor 3
(eIF-3) complex, which is involved in protein synthesis of a
specialized repertoire of mRNAs and, together with other initiation
factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
ribosome. The eIF-3 complex specifically targets and initiates
translation of a subset of mRNAs involved in cell proliferation.



GO - Cellular Component
eukaryotic 43S preinitiation complex	GO:0016282	IEA:UniProtKB-UniRule
eukaryotic 48S preinitiation complex	GO:0033290	IEA:UniProtKB-UniRule
eukaryotic translation initiation factor 3 complex	GO:0005852	IEA:UniProtKB-UniRule
Golgi membrane	GO:0000139	IEA:UniProtKB-SubCell
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
carbohydrate binding	GO:0030246	IEA:UniProtKB-KW
ribosome binding	GO:0043022	IEA:InterPro
transferase activity, transferring glycosyl groups	GO:0016757	IEA:UniProtKB-KW
translation initiation factor activity	GO:0003743	IEA:UniProtKB-UniRule
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
formation of cytoplasmic translation initiation complex	GO:0001732	IEA:UniProtKB-UniRule
protein glycosylation	GO:0006486	IEA:UniProtKB-UniPathway
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro
regulation of translational initiation	GO:0006446	IEA:InterPro
transcription, DNA-templated	GO:0006351	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10863
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.41|      28|      37|    1030|    1059|       1
---------------------------------------------------------------------------
 1030- 1059 (48.56/44.47)	NCLDTmGHKSGeKVGSSYCHGLGGNQVFAY
 1070- 1097 (58.85/42.42)	NCLDA.SNANG.PVNLVRCHGMGGNQEWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.48|      27|      58|     830|     856|       2
---------------------------------------------------------------------------
  830-  856 (54.12/30.96)	ISDETFEYVTASDQ...TWGGFNWKLNFR.W
  887-  917 (44.36/24.14)	IDKDYFYEIGSYDEgmdIWGGENLEMSFRvW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     680.42|     240|     293|      89|     381|       3
---------------------------------------------------------------------------
   89-  370 (345.69/304.99)	CKylllPTQmrddtvkeiiYIADILEQCDFVLFWQT.VQNKGALFEKITGFYD....SVR.KFVCHVVGTT.FQTVD.........KVYLSKLLG.NVDDKQLThwvkkhnwTMQGDIVTIIKQEETIKTKHIAEKIDFESLGGLMAN...CFSTNNNK.MSVEDEVLRihKKLSkitssgtdNQTQALDLLKALQNLKIDLDILTSTRIGMAVNELRKcSKDE.....EVINLS..KKLI.....................................KNWKkllasnPeSPKSSQKSSNGSSASKPSSKDSNKDDKIKDsKSKsSSQTNFPPPS....SSSTTDVVRLKC
  387-  695 (334.73/221.49)	CA....SAE..........ELAEELEEAIFAEFKNTdMKYKNRIRSRVSNLKDtknpGLRnNFITGVISASrFAKMTpeemandemKKLREKFVKeSINDAQLA........TVQGTKTDLLKCGKCKKKDCTYNQLQTRSADEPMTTfvmCNACEQGKsMSNYTRMFR..GKMR........TSTCRIILITSLAWLLIDVIIIMKYTDGLNGGIFKK.SRDNgqqshNVASLSggHHVIdedpivdeeeidtnlnnidngdeivkrisktyrtvdlKKWR......P.APVVKENPGKPGEMGKPVKMKSYQQEEMKE.KFK.ENQFNLLASDmiwlNRSLSDVRHKDC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10863 with Med26 domain of Kingdom Metazoa
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