<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10858

Description "CLUMA_CG011350, isoform A"
SequenceMFSETYVEKRPLKKPKLGPADVYPQEIKQKEDELTSLNVKHGFATMPQLSEEFGTARNYNVTASKVGAYFNAILAKKEELMTLTDSGRKKQHVKDNFWPVTQRTKQTLDNWFKDLAGNKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTSTMIKFLKDLIPKLIEYYHTASPAGASSSLVPVPSTPQEEQKLALKQWTYCTQLCKYMFEEGLLDKHEFLNWILDLFDKLRTQPTEDGILKLYLPLALSYMQDFVQSERLSRKLAYLSSKKLSTMIYEMVNHLNLDTNSKQDQNNGKNQETNGKNLNPYEKALEEYLSCPQHRDTVIQLSCMLQVVTLDCPTALIWSGVGENRPSVLSGSPLDYLPVAPSTLPMPEKSPKSNEEYRLKLKIAENSIKHRSQQAESRWCADKWRTISGNSTVKLLTILDTLDSYFFDRMDVNNSLDTLYAKIFPSLPDNSKELNSSDGKDTKIEYDVNSDEDTVKILCEWAVSTHRWGEHRAMAVGRLLDKRQTEISMNENDNNNIEDKDSDFGANGTPIFQGILLRFLDTAPVLEENGNAQNKAQFKNLIHLFSELIRNDVFSHDGYMCTLISRGDLLNGAPPNLNPSVHGKNQSTNTGGGGDDDFFSEIDFKPPKMEEFDDSNVDDDLEKLIQNIKDGQNNSMDAPDSPKDNENLTNLHSLSTEKNSNSTSANCRHYLYTMHFPLSQDDASQHDCNQRYILLYGVGKERDERKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFESTLNKCQSMCYFDQHFVTWQCAVTVQEMLNSFAMGNSNYLPVAEHVAFLFDLMEVALNIYGVIDMCIQILKELPDVESQLMAKNSNLIKSYTTTMSLYVVGILRRYNSCLLLSPEQTTAVFEGLCKVVKHVSNPSDCSSAERCILAYLYELYLACSILKTKPPSEPFHNAYPKIKQTIYAPIKLIPTTQPFNAQFMADILSNPKRGGKIESSWGRQLSESAMNRYSFVCNAIIAITRETDNDKLNDIAIMCAELTACCNSLSAEWLGALVALCNTKNESGYYMEILNTVDLQNVHMYNSVAVFTCILVARHCFTLVDFVATVALPALLIYYRSETIMNEVEASARLTCHILLRLFQAIEYPQPGMYSVSTSPIQVSGPMNSNIKLSCDRLLLGGAHKNISVAPVLAVLKAILVVADATVHKTSYGSGGEKSGLNTPVHPGSTPKSMSGPVDLSHILGTREDLGMLGDGDDPMLELGNSNNNLNSNENAPSLSEFAQHVLKQICTQEWVLECCLKNCDEMCKDEILLDNMLTNKQAQRLLHMICYDQDTNAKIESNMDQKSQIVRILENLEQWSLRISLLDLQLMYKQTQSNSSEFSSWLDTVARAAIDVFIPNQERKQGRKPPIWLVAPLVAKLPCEVQGRILKVAGQVLESTNSFGTKNKSSENSETSGGSGRRRSVQIDQQPFLGLVLTCLKGQDDQKEGLLQSLHSQLSQFLQNKELEFVGGIDDPTGREEMLNALQLRFSLVGGMFDSIQKNSTSTTDWALLLAQLMSQGVIDLNNNSELFHTALDMLATLIHSTLITDSQSERDENKKLNTNLVKKLRKELADKNSATIKLVRQLLPLAKPACANSCEVIACEPVGSLMDTKGLRITEKERVSIGATGTKTRKGTKRPRKPKGNATPAPLPNQQLQNPMPAQMPNQGMNPMMNQHLMNPQMSQQFNPNQPPQQQQQQQQMGGNMGMMQNNSMMMNQMGMEMGQGMPQNQMQMNQMGINPMQQQQQQQQQQQSQPTNMNQINPMQYQQQQQQQQQIGQLSQMSQMNMNQQNINVNMNMNQMGQQNQQWGGYNQMQNQQAQVQTSQGNQQFYNQAGIPAAAPQMNQFPERPQLNQSKQALSNMLRQRHPNQNVPFNIHQQRMQMVQNQNRQQMQQLAQRQMMYRARMAGKPMNNPGMLSQQANAASAINPMVQQTPGNMMQGGQQAIMSGGNQNPALMAQQGASSMGMNQQNPNVMQASQPQQTILPGPSSGGIIPPNSIAPAMLQNAQQSQASQMINQPNMIQQNVGNQMGNLSSQMGQGGGANQNQQANMFPNQYQNMNQNYSGYNNPNMSANQPNVQGGNQGNLMTNFQQNQAVGGNQQRNPQADFIAQQRRNQYLQQQQQQQQQQQQNQQTPNVTMNTNISVGPQGNVPPPYRQGGKPMVNPSSQPFQDMRMRQLMMKQQQQQQQQGMAQQSNNPSMAQGMVPNQGGLSQQTPSALVAQLQRQLPNQMNPNMMNQQQNQQNFNQGPF
Length2310
PositionKinase
OrganismClunio marinus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Chironomoidea> Chironomidae> Clunio.
Aromaticity0.06
Grand average of hydropathy-0.607
Instability index48.22
Isoelectric point7.06
Molecular weight259321.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10858
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.87|      20|      20|    1792|    1811|       1
---------------------------------------------------------------------------
 1792- 1811 (46.12/18.91)	Q...MNQMGINPMQQQQQQQQQQ
 1814- 1834 (33.85/11.51)	QptnMNQ..INPMQYQQQQQQQQ
 2173- 2189 (27.61/ 7.74)	R...RNQY...LQQQQQQQQQQQ
 2232- 2250 (28.29/ 8.15)	D...M.RMRQLMMKQQQQQQQQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     554.23|      78|     312|    1713|    1790|       5
---------------------------------------------------------------------------
 1713- 1757 (86.06/26.31)	...........................................................................N.QQL.QNPM..PAQMPNQ..............................................G..................M....NP.MMNQHL.MNPQM.SQQFNP.......................NQ......P..PQ.....................QQQQ
 1758- 1864 (60.54/16.42)	QQQM..GGN.....................MGMMQ...NNSMMMN..QMG...MEMGQGMPQNQ..............................mqmnqmginpmqqqqqqqqqqqsqptnmnqinpmqyqqqqqqqqqiGqlsqmsqmnmnqqninvnM....N...MN.......QM.G................................................................QQ
 1865- 1914 (88.22/27.15)	NQQW..GG......................YNQMQ...N.....Q..QAQ...VQTSQG................N.QQF.YN....QAGIP................................................A..................A....AP.QMNQ............F.P.......................ER......P.........................QLNQ
 1915- 1994 (78.18/23.26)	SKQA..LSN.....................M.LRQrhpNQNVPFNihQQR...MQMVQ..NQNR.........qqM.QQLaQRQMmyRARMAGK.......................................................................P.M......NNPGMlSQQANA.......................AS......AinPM.....................VQQT
 1995- 2071 (56.80/14.97)	PGNMmqGGQqaimsggnqnpalmaqqgassMGM..........................................N.QQN.PNVM..QASQPQQ..............................................T..................I....LP.........GPSS.GGIIPP.......................NSiapamlQ..NA.....................QQSQ
 2072- 2161 (75.50/22.22)	ASQM..INQ.....................PNMIQ...QN..VGN..QMGnlsSQMGQGGGANQ................................................................................................nqqaNM.FPNQYQnMNQNY.SGYNNPnmsanqpnvqggnqgnlmtnfqqNQ......A..VG.....................GNQQ
 2190- 2254 (50.06/12.36)	QNQQ..TPN.....................VTMNT...NISV..................................gPQG.NVPP..PYR...Q..............................................G..................G....KP.M......VNP........S.......................SQ......P..FQdmrmrqlmmkqqqqqqqqgmaQQ..
 2255- 2309 (58.86/15.77)	......S...............................NNP.............SMAQGMVPNQgglsqqtpsalV.AQL.QR......QLPNQ.................................................................M....NPnMMNQ......QQ.NQQ.NF.......................NQ......G..P..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.21|      26|     538|     602|     627|       6
---------------------------------------------------------------------------
  602-  627 (46.70/32.21)	LIHLFSELIRNDVFSHDGYMCTLISR
 1134- 1159 (44.51/30.35)	LIYYRSETIMNEVEASARLTCHILLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.22|      33|     493|     801|     834|      10
---------------------------------------------------------------------------
  801-  834 (60.12/45.11)	SEFNFESTlNKCQSMCYFDQHFV......TWQ...CAVTVQEM
 1284- 1325 (49.10/31.36)	SNNNLNSN.ENAPSLSEFAQHVLkqictqEWVlecCLKNCDEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.57|      41|     250|    1231|    1277|      15
---------------------------------------------------------------------------
 1235- 1277 (66.97/60.30)	EKSGLNTPVHPGStPKSMSGPVDLSHILGTRE.dLGMLGDGDDP
 1466- 1504 (56.10/30.84)	NKSSENSETSGGS.GRRRSVQIDQQPFLG...lvLTCLKGQDD.
 1517- 1535 (21.50/ 6.35)	.......................LSQFLQNKE..LEFVGGIDDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     129.28|      47|     250|    1354|    1400|      17
---------------------------------------------------------------------------
 1354- 1376 (22.39/ 9.48)	.............................................TNAKIESNMDQK..SQIVRIL..ENLE
 1377- 1400 (27.99/14.37)	QWSLRISLL.DLQLMYK...QTQSNSSE............................................
 1568- 1634 (39.44/24.35)	DW....ALL.LAQLMSQgviDLNNNSELfhtaldmlatlihstliTDSQSERDENKKlnTNLVKKLrkELAD
 1635- 1673 (39.46/24.37)	KNSATIKLVrQLLPLAK...PACANSCE...............viACEPVGSLMDTK...............
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10858 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDLEKLIQNIKDGQNNSMDAPDSPKDNENLTNLHSLSTEKN
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
3) NGAPPNLNPSVHGKNQSTNTGGGGDDDFFS
680
1671
632
720
2310
661










Molecular Recognition Features






MoRF SequenceStartStop




1) KPPKME
666
671