<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10856

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLIQEPVQVAIWTNLNFYAYEDATFLAERLCSEIETDESLFLLATCYYRSGRTNEAYWLLSTKGAQTQKSKFLLAKCAYELKHYSEAESVLCQNKSPKTISDLDEICKEFGELSGFVMQLLSKICKQTERAAMANECCRASLKQNPFLWNSFVDLCNRGERPNPKEIFQIRNDELLSQLERQLWSNPSPEFHLYDKNVSIHEQQQQPPPTCVITPNNANIEKFEVDVEDTPLMENLNQTSLTSQPRIHEQTPYRKQFKYLQSNMIPITPSFGVLPLNSPFDSLKQTTLFLTPSPPLTTQQQTQQQQQQIIDCEKNNSNKKIRGNLNSLVTRKEIATPLQQTKPVVLNQSSNITPNRTQFMQQQQQDQRYPSVRRSSRIFSNYSVKENNKSPNLNKFVQPRSPPSKKANKRVSKSSKTTLNELNEKNNMLSEKERSETITSAQLINDMSYLQQSNHIASLKRQSADGLLQLLQELGQAYMHIQHYEMNEAVNVLESNIPTRHFNSSWVQSMIALIHHENREYEEAVKIFTVIHKREPFRLQFMEIYSTDLWHLQKDALLSMLTQDMIQHNKTSAITWCVAGNCYSALKEHDTAIKFFNRAIQVDPDFPYSYTLLGHELVVTEELEKALGCYRKAILKDPRHYNAWFGIGTIYSKQERFQLAEIHYRHALKINRKNSVILVHIGVMQFYLHKPEHAIQTLTEGIKLEPNNPLCKFHRASMNFSIGKLQEALSELEELKQIVPKESVVYYLIGKIHKQLGNIDLALMHFSWATDLDPKGANNQIKDKFDSVIRSHQQPEQSEGIPLREDFVEDDDVSDDEAAPGNDNDNNNSSGTIEESDITMTHQNHQTNGASLEDCHTNFFALADLCGIKWKKLVLNERPLSTGDPLDDPVLRSYTKCLAKDILCVWRRVSQHKNDLDQTGGLGMFDISQIGCTSVIHPPLSLTAAKELWIFWYGEEPDLTDLVSPELLKSPDSLEQGSWESGLSYECRSLLFKALHNLIERCLLSRDILRLGKWFVQPSLEKNAGKSSAHLSFSFAFFVHGESTVCASMDIREHPPVRPLTEEYLNEVIKNSQQTESCSLNDDNDKEDFNDINHNVSVQSVILAPFGLSAVLTGNKSENYEQYTEKIVNDWNNFYPMKKLDGDNSSSNMPQLVEVISGGIKMLYPSKYVLVTDILSRNKKDNCISENNKKIINSSETKSSYRCSEIDKDCIESSVLNFCDGIQKTASGVLPERAWQDSIMNPAYTNASVKSEQEKIEMQSENNIENSINAANGIEKSDPTTWNFVEPNHKSNCLCTRCKNVENHGSFSSLKTPGNSSSISGKSNFRNNSNRNRTPFHKRYKKLLHFDDDHKTNHKIFVTYECRSSSDSSLSKSKERFSNQPSTSSKFNIRSSVKQSSGGSGSNGGNASQTQNSNNTNEVQQMSIGSDGSIQSPMHHNLSSVHSQPSSVPVNEQNILSPIPPSDVSPPSMTPSLENNIDQKPDIQSLNNFDKTTDNSQTNHQANNNDGGSIDNGNNTKIDFKSNNNSKQKLTDTNNKENICLKRPALKVQDCEDISEEDHSISQSLYDYSTWDAWMNHPIKRFKPDDLDRNRSNNKSSTKYDLYAGQTCSESSSVLPNLVQQIQNLNESGKIDDAKNNLNNNCGKDNRNVNGGNCVGGGSGGVDNDPDKNSNSENLFTSEGLQPSYADLNKIFDNSDDNSNDDHLVDNTPPGSNKSIGCHPADMEVPGGVCGNISDSLMESIDMMPSTKSDSYHNLGSPHEEPIDDWSFVFKPPKKSTIVGASKYAPLDNLLSQTLPPINLPSNCNYKPSWIKQKEQDEVRKKQQQLQADNNGSLMIKKEIINPPPLPEPPSIEIKKEVMSPMNVKMMASSPYGGVKNIKTENVGSTIINKLLTQGPTPPPNVFKSSIHSSMGSPSPANLQTNNYISPYPPMSHQDSIFRKTMVGIGMPMSSSHHSQPPPPYDVAIHSPSLNSNLNSISSNNDENKQKILSNNNNIKGNHPHHPQHHFMTQQQQQHQLQQHQQQSLNGQKTPEANSLLVNVLLYDTSLNIFRDHNFDSCTICVCNAGPKCVGNIRGLDSGLYLSLAASCHFNENLTTIVERYEHEITGMAKDPSNFKKRSLLSLLLKQRQQNKFNQHQNDDDSKQQQQNDSTMKEMKEISIANLSPIFDLLRNQCTLFHNSSNSVQRAIKHLNQEKYSPIIANKHVNILEYIDAFDIVTLALEQGRYVFERFDGYNNRQLYIPNQQQQQKNNNNQVVEKQSTSLLSQQQQQQAISVHKWPYLNAAGPKSNQDIIRVMKSMQVLLQKAFNQNGTTGLWDAPYAVRGPLTWREFHRLAGRGIGQCEPQPVPSVVVGHDKEWLCVSPYALQFWDKLLLEPYSHPRDIAYIVVSPDNHFITSRVKMFFKELSTTYEMCRLGRHQPVKEWEGILRVGKSVVKQENNNFDDDWLQSSLDSNKLNELLRLYGIAFQQSLVGFLSKIPYDKTLLNPPENCYNNHNSYKDHHHHHSHQRPSSLSSPMLPPHTPDSSMSANGSNNNNNNMSSMSHHDKGPNTPKSDQDDTKENLNNSTSTSEIMSQQLDQLANPPHIVLYIVEPFTSGTDSTSLERVACLSLLKYYSNVLSSIPESVKTNISVQIIAQESILELGRNRDINRWSDHMRNLALNVFTQSHRYLSHSNSVKSLTGFGTAANAEAFMKTKDEKNKAPVKLYTPPYILSTRNAKSENVENFGQSGIEQQCSSIMYCCYCLSEDQSMLLAVLTDERGEFLENCTINIDVPNRKRRKKTSARRIALQKLMDFILGVMSQTVKPWRLVIGRIGRIGHGELKGWSWLLSKPNLVKASKYLKDICKQCSVMYPQSVPSIWSACLVTLEPDSNFRVMPDQFTPDERFSQRSTQSPLSTPQDVSCTHILVFPTSAILQSSQATFHEQHLENALDFGEDFIIDDTDDVDEDINGIQHLFDEWNESAVGIPQASPTRDSHRGSPLTLDENKSRQSPGMTDNQTGQSRNIYSMPEAEEVGQLLQQPLALGYLVSTAPTGRMPSWFWACCPHLESVCPVFLKTALHIHSPSIHKENDDIYYKEQSSKIEHPLDSNTTADVLRYVLEGYNVLSWLAMDSNTHDRLSCLPIHVQMLMQLYHLHTALA
Length3139
PositionMiddle
OrganismClunio marinus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Chironomoidea> Chironomidae> Clunio.
Aromaticity0.07
Grand average of hydropathy-0.666
Instability index55.97
Isoelectric point6.15
Molecular weight354953.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10856
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.47|      30|      33|      35|      67|       1
---------------------------------------------------------------------------
   38-   67 (54.60/52.54)	ESLFLLATCYYRSGRTNEAYWLL.STKGAQT
   69-   99 (47.86/34.36)	KSKFLLAKCAYELKHYSEAESVLcQNKSPKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.08|      33|      33|     668|     700|       2
---------------------------------------------------------------------------
  668-  700 (55.86/43.34)	LKINRKNSVILVHIGVMQFYLHKPEHAIQTLTE
  702-  734 (56.23/43.69)	IKLEPNNPLCKFHRASMNFSIGKLQEALSELEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      89.94|      14|      58|     295|     308|       3
---------------------------------------------------------------------------
  295-  308 (28.28/16.02)	PLTTQ.QQTQQQQQQ
  354-  368 (22.17/10.79)	PNRTQfMQQQQQDQR
 2009- 2019 (17.21/ 6.54)	...TQ.QQQQHQLQQ
 2258- 2271 (22.29/10.90)	KQSTS.LLSQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.76|      22|      33|    1346|    1378|       4
---------------------------------------------------------------------------
 1346- 1371 (33.01/35.84)	FDDDHKTNhkifVTYECRSSSDSSLS
 1381- 1402 (36.75/14.15)	PSTSSKFN....IRSSVKQSSGGSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     185.17|      33|      33|    1898|    1930|       5
---------------------------------------------------------------------------
 1432- 1461 (30.87/10.30)	.....SPMHHNLSSvhsqPSS....VPVNEQNILSPIPP................
 1748- 1774 (35.74/13.16)	K....SDSYHNLGS....PHE....EPIDDWSFVFK.PP..........K.....
 1855- 1903 (30.56/10.12)	KkevmSPMNVKMMA....SSPyggvKNIKTENVGSTI..inklltqgptPPPNVF
 1904- 1938 (56.28/25.23)	K....SSIHSSMGS....PSP....ANLQTNNYISPYPP........msHQDSIF
 1939- 1961 (31.72/10.80)	R....KTM.VGIGM....PMS....SSHHSQ.................pPPP..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.02|      46|     587|     169|     240|       6
---------------------------------------------------------------------------
  195-  240 (82.22/92.22)	DKNVSIHEQQQQPPPTCVITPNNANIEKFEV.DVEDTPLMENLNQTS
  783-  829 (76.81/38.21)	DKFDSVIRSHQQPEQSEGIPLREDFVEDDDVsDDEAAPGNDNDNNNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.05|      28|      33|     949|     979|       7
---------------------------------------------------------------------------
  951-  979 (48.70/38.75)	FWYGEEP....DLTDLVSPELLkSPDSLEQGSW
  983- 1014 (45.35/23.48)	LSYECRSllfkALHNLIERCLL.SRDILRLGKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.05|      27|      34|     116|     149|       9
---------------------------------------------------------------------------
  121-  149 (43.33/40.63)	LSKICKQTERAA......MANECCRASLKQNpfLW
  152-  184 (41.72/19.62)	FVDLCNRGERPNpkeifqIRNDELLSQLERQ..LW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.26|      46|      59|    1630|    1684|      10
---------------------------------------------------------------------------
 1595- 1641 (71.97/39.15)	KSSTKYDLYAGQTCSESSSVL...PNLVQQIQNLNES..........gKI.DDAKNNLNNN
 1642- 1702 (62.29/49.42)	CGKDNRNVNGGNCVGGGSGGVdndPDKNSNSENLFTSeglqpsyadlnKIfDNSDDNSNDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.82|      67|     585|    2077|    2152|      11
---------------------------------------------------------------------------
 2077- 2149 (100.18/75.46)	DSGLYLSLAASC.....HFN.ENLTTIVERyEHeiTGMAKDPSNFkkrSLLSLLLKQRQQ..NKFNQHQNDD...DSKQQQQND
 2173- 2250 (96.64/50.26)	QCTLFHNSSNSVqraikHLNqEKYSPIIAN.KH..VNILEYIDAF...DIVTLALEQGRYvfERFDGYNNRQlyiPNQQQQQKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     818.22|     203|     376|    2315|    2564|      12
---------------------------------------------------------------------------
 2315- 2522 (346.33/215.59)	LWDAPYAvrGPLTWREFHRLAGRGIGQCE.PQPVPSVV...VGHDKEWLCVsPYALQFWDKLLLEPYSHPRD..IAYIV.VSPDNHFITSRVKMFFKELSTTYE.M.CRLG.RHQPVKEWEGIL.RVGKSVVKQENNNF....DDDWLQSSLD....SNKLNELLR....LYGI....AFQQSLVGFLSKIPydKTLLNPPENCYNNHNSYKDHHHHHSHQRPSSLSSPMLPPHT
 2706- 2904 (287.48/162.41)	LYTPPYI....LSTRNAKSENVENFGQSGiEQQCSSIM.........YCC...YCLSEDQSMLLAVLTDERGefLENCT.INIDVPNRKRRKKTSARRIALQKL.MdFILGvMSQTVKPWRLVIgRIGR.IGHGELKGW......SWLLSKPNlvkaSKYLKDICK....QCSV....MYPQSVPSIWSAC...LVTLEPDSNFRVMPDQFTPDERFSQRSTQSPLSTPQDVSCT
 2964- 3122 (184.42/147.42)	V.GIPQA..SPT..RDSHRGSPLTLDENK.SRQSPGMTdnqTGQSRNIYSM.PEAEEV.GQLLQQPLA......LGYLVsTAP.....TGRMPSWFWACCPHLEsV.C.......PV.FLKTAL.HIHSPSIHKENDDIyykeQSSKIEHPLD....SNTTADVLRyvleGYNVlswlAMDSNTHDRLSCLP...........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      17|      33|     477|     493|      13
---------------------------------------------------------------------------
  477-  493 (31.17/20.19)	AYMHIQHYEMNEAVNVL
  512-  528 (29.56/18.73)	ALIHHENREYEEAVKIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.43|      42|      59|    1494|    1535|      14
---------------------------------------------------------------------------
 1274- 1300 (34.06/12.45)	........IEKS..DPTTWN.........FvEPNHKSNCLCTRCKN
 1494- 1535 (72.49/35.53)	DNSQTNHQANNN..DGGSIDNGNNTKID.F.KSNNNSKQKLTDTNN
 1553- 1594 (59.89/27.97)	DISEEDHSISQSlyDYSTWDAWMNHPIKrF.KPDDLDRNR...SNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.96|      24|      33|     370|     393|      15
---------------------------------------------------------------------------
  370-  386 (21.42/ 9.72)	................PSVRRSSRI..FSNYSVKE
  387-  421 (26.20/13.94)	NNKSPNLnkfvqprspPSKKANKRVskSSKTTLNE
  423-  440 (22.33/10.52)	NEKNNML.........SEKERSETI..TS......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.91|      22|      34|     849|     882|      16
---------------------------------------------------------------------------
  849-  872 (33.58/46.39)	GASLED....CHTNFFALADLCgIkWKK
  883-  908 (37.32/16.73)	GDPLDDpvlrSYTKCLAKDILC.V.WRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.90|      32|      52|    1188|    1221|      17
---------------------------------------------------------------------------
 1188- 1221 (47.94/34.09)	NKKIINSSETKSSYRcSEIDK......DCIESSVlNFCDG
 1236- 1273 (48.96/25.62)	QDSIMNPAYTNASVK.SEQEKiemqseNNIENSI.NAANG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.62|      28|      32|    1115|    1146|      18
---------------------------------------------------------------------------
 1119- 1146 (53.08/40.51)	NYEQYTEKIVNDWNNFYPMKK.LDGDNSS
 1148- 1176 (44.54/23.31)	NMPQLVEVISGGIKMLYPSKYvLVTDILS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.53|      19|      22|     252|     270|      21
---------------------------------------------------------------------------
  252-  270 (35.83/21.41)	PYRKQFKYLQSNMIPITPS
  275-  293 (33.70/19.64)	PLNSPFDSLKQTTLFLTPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10856 with Med13 domain of Kingdom Metazoa
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