<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10856

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLIQEPVQVAIWTNLNFYAYEDATFLAERLCSEIETDESLFLLATCYYRSGRTNEAYWLLSTKGAQTQKSKFLLAKCAYELKHYSEAESVLCQNKSPKTISDLDEICKEFGELSGFVMQLLSKICKQTERAAMANECCRASLKQNPFLWNSFVDLCNRGERPNPKEIFQIRNDELLSQLERQLWSNPSPEFHLYDKNVSIHEQQQQPPPTCVITPNNANIEKFEVDVEDTPLMENLNQTSLTSQPRIHEQTPYRKQFKYLQSNMIPITPSFGVLPLNSPFDSLKQTTLFLTPSPPLTTQQQTQQQQQQIIDCEKNNSNKKIRGNLNSLVTRKEIATPLQQTKPVVLNQSSNITPNRTQFMQQQQQDQRYPSVRRSSRIFSNYSVKENNKSPNLNKFVQPRSPPSKKANKRVSKSSKTTLNELNEKNNMLSEKERSETITSAQLINDMSYLQQSNHIASLKRQSADGLLQLLQELGQAYMHIQHYEMNEAVNVLESNIPTRHFNSSWVQSMIALIHHENREYEEAVKIFTVIHKREPFRLQFMEIYSTDLWHLQKDALLSMLTQDMIQHNKTSAITWCVAGNCYSALKEHDTAIKFFNRAIQVDPDFPYSYTLLGHELVVTEELEKALGCYRKAILKDPRHYNAWFGIGTIYSKQERFQLAEIHYRHALKINRKNSVILVHIGVMQFYLHKPEHAIQTLTEGIKLEPNNPLCKFHRASMNFSIGKLQEALSELEELKQIVPKESVVYYLIGKIHKQLGNIDLALMHFSWATDLDPKGANNQIKDKFDSVIRSHQQPEQSEGIPLREDFVEDDDVSDDEAAPGNDNDNNNSSGTIEESDITMTHQNHQTNGASLEDCHTNFFALADLCGIKWKKLVLNERPLSTGDPLDDPVLRSYTKCLAKDILCVWRRVSQHKNDLDQTGGLGMFDISQIGCTSVIHPPLSLTAAKELWIFWYGEEPDLTDLVSPELLKSPDSLEQGSWESGLSYECRSLLFKALHNLIERCLLSRDILRLGKWFVQPSLEKNAGKSSAHLSFSFAFFVHGESTVCASMDIREHPPVRPLTEEYLNEVIKNSQQTESCSLNDDNDKEDFNDINHNVSVQSVILAPFGLSAVLTGNKSENYEQYTEKIVNDWNNFYPMKKLDGDNSSSNMPQLVEVISGGIKMLYPSKYVLVTDILSRNKKDNCISENNKKIINSSETKSSYRCSEIDKDCIESSVLNFCDGIQKTASGVLPERAWQDSIMNPAYTNASVKSEQEKIEMQSENNIENSINAANGIEKSDPTTWNFVEPNHKSNCLCTRCKNVENHGSFSSLKTPGNSSSISGKSNFRNNSNRNRTPFHKRYKKLLHFDDDHKTNHKIFVTYECRSSSDSSLSKSKERFSNQPSTSSKFNIRSSVKQSSGGSGSNGGNASQTQNSNNTNEVQQMSIGSDGSIQSPMHHNLSSVHSQPSSVPVNEQNILSPIPPSDVSPPSMTPSLENNIDQKPDIQSLNNFDKTTDNSQTNHQANNNDGGSIDNGNNTKIDFKSNNNSKQKLTDTNNKENICLKRPALKVQDCEDISEEDHSISQSLYDYSTWDAWMNHPIKRFKPDDLDRNRSNNKSSTKYDLYAGQTCSESSSVLPNLVQQIQNLNESGKIDDAKNNLNNNCGKDNRNVNGGNCVGGGSGGVDNDPDKNSNSENLFTSEGLQPSYADLNKIFDNSDDNSNDDHLVDNTPPGSNKSIGCHPADMEVPGGVCGNISDSLMESIDMMPSTKSDSYHNLGSPHEEPIDDWSFVFKPPKKSTIVGASKYAPLDNLLSQTLPPINLPSNCNYKPSWIKQKEQDEVRKKQQQLQADNNGSLMIKKEIINPPPLPEPPSIEIKKEVMSPMNVKMMASSPYGGVKNIKTENVGSTIINKLLTQGPTPPPNVFKSSIHSSMGSPSPANLQTNNYISPYPPMSHQDSIFRKTMVGIGMPMSSSHHSQPPPPYDVAIHSPSLNSNLNSISSNNDENKQKILSNNNNIKGNHPHHPQHHFMTQQQQQHQLQQHQQQSLNGQKTPEANSLLVNVLLYDTSLNIFRDHNFDSCTICVCNAGPKCVGNIRGLDSGLYLSLAASCHFNENLTTIVERYEHEITGMAKDPSNFKKRSLLSLLLKQRQQNKFNQHQNDDDSKQQQQNDSTMKEMKEISIANLSPIFDLLRNQCTLFHNSSNSVQRAIKHLNQEKYSPIIANKHVNILEYIDAFDIVTLALEQGRYVFERFDGYNNRQLYIPNQQQQQKNNNNQVVEKQSTSLLSQQQQQQAISVHKWPYLNAAGPKSNQDIIRVMKSMQVLLQKAFNQNGTTGLWDAPYAVRGPLTWREFHRLAGRGIGQCEPQPVPSVVVGHDKEWLCVSPYALQFWDKLLLEPYSHPRDIAYIVVSPDNHFITSRVKMFFKELSTTYEMCRLGRHQPVKEWEGILRVGKSVVKQENNNFDDDWLQSSLDSNKLNELLRLYGIAFQQSLVGFLSKIPYDKTLLNPPENCYNNHNSYKDHHHHHSHQRPSSLSSPMLPPHTPDSSMSANGSNNNNNNMSSMSHHDKGPNTPKSDQDDTKENLNNSTSTSEIMSQQLDQLANPPHIVLYIVEPFTSGTDSTSLERVACLSLLKYYSNVLSSIPESVKTNISVQIIAQESILELGRNRDINRWSDHMRNLALNVFTQSHRYLSHSNSVKSLTGFGTAANAEAFMKTKDEKNKAPVKLYTPPYILSTRNAKSENVENFGQSGIEQQCSSIMYCCYCLSEDQSMLLAVLTDERGEFLENCTINIDVPNRKRRKKTSARRIALQKLMDFILGVMSQTVKPWRLVIGRIGRIGHGELKGWSWLLSKPNLVKASKYLKDICKQCSVMYPQSVPSIWSACLVTLEPDSNFRVMPDQFTPDERFSQRSTQSPLSTPQDVSCTHILVFPTSAILQSSQATFHEQHLENALDFGEDFIIDDTDDVDEDINGIQHLFDEWNESAVGIPQASPTRDSHRGSPLTLDENKSRQSPGMTDNQTGQSRNIYSMPEAEEVGQLLQQPLALGYLVSTAPTGRMPSWFWACCPHLESVCPVFLKTALHIHSPSIHKENDDIYYKEQSSKIEHPLDSNTTADVLRYVLEGYNVLSWLAMDSNTHDRLSCLPIHVQMLMQLYHLHTALA
Length3139
PositionMiddle
OrganismClunio marinus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Chironomoidea> Chironomidae> Clunio.
Aromaticity0.07
Grand average of hydropathy-0.666
Instability index55.97
Isoelectric point6.15
Molecular weight354953.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10856
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.47|      30|      33|      35|      67|       1
---------------------------------------------------------------------------
   38-   67 (54.60/52.54)	ESLFLLATCYYRSGRTNEAYWLL.STKGAQT
   69-   99 (47.86/34.36)	KSKFLLAKCAYELKHYSEAESVLcQNKSPKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.08|      33|      33|     668|     700|       2
---------------------------------------------------------------------------
  668-  700 (55.86/43.34)	LKINRKNSVILVHIGVMQFYLHKPEHAIQTLTE
  702-  734 (56.23/43.69)	IKLEPNNPLCKFHRASMNFSIGKLQEALSELEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      89.94|      14|      58|     295|     308|       3
---------------------------------------------------------------------------
  295-  308 (28.28/16.02)	PLTTQ.QQTQQQQQQ
  354-  368 (22.17/10.79)	PNRTQfMQQQQQDQR
 2009- 2019 (17.21/ 6.54)	...TQ.QQQQHQLQQ
 2258- 2271 (22.29/10.90)	KQSTS.LLSQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.76|      22|      33|    1346|    1378|       4
---------------------------------------------------------------------------
 1346- 1371 (33.01/35.84)	FDDDHKTNhkifVTYECRSSSDSSLS
 1381- 1402 (36.75/14.15)	PSTSSKFN....IRSSVKQSSGGSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     185.17|      33|      33|    1898|    1930|       5
---------------------------------------------------------------------------
 1432- 1461 (30.87/10.30)	.....SPMHHNLSSvhsqPSS....VPVNEQNILSPIPP................
 1748- 1774 (35.74/13.16)	K....SDSYHNLGS....PHE....EPIDDWSFVFK.PP..........K.....
 1855- 1903 (30.56/10.12)	KkevmSPMNVKMMA....SSPyggvKNIKTENVGSTI..inklltqgptPPPNVF
 1904- 1938 (56.28/25.23)	K....SSIHSSMGS....PSP....ANLQTNNYISPYPP........msHQDSIF
 1939- 1961 (31.72/10.80)	R....KTM.VGIGM....PMS....SSHHSQ.................pPPP..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.02|      46|     587|     169|     240|       6
---------------------------------------------------------------------------
  195-  240 (82.22/92.22)	DKNVSIHEQQQQPPPTCVITPNNANIEKFEV.DVEDTPLMENLNQTS
  783-  829 (76.81/38.21)	DKFDSVIRSHQQPEQSEGIPLREDFVEDDDVsDDEAAPGNDNDNNNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.05|      28|      33|     949|     979|       7
---------------------------------------------------------------------------
  951-  979 (48.70/38.75)	FWYGEEP....DLTDLVSPELLkSPDSLEQGSW
  983- 1014 (45.35/23.48)	LSYECRSllfkALHNLIERCLL.SRDILRLGKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.05|      27|      34|     116|     149|       9
---------------------------------------------------------------------------
  121-  149 (43.33/40.63)	LSKICKQTERAA......MANECCRASLKQNpfLW
  152-  184 (41.72/19.62)	FVDLCNRGERPNpkeifqIRNDELLSQLERQ..LW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.26|      46|      59|    1630|    1684|      10
---------------------------------------------------------------------------
 1595- 1641 (71.97/39.15)	KSSTKYDLYAGQTCSESSSVL...PNLVQQIQNLNES..........gKI.DDAKNNLNNN
 1642- 1702 (62.29/49.42)	CGKDNRNVNGGNCVGGGSGGVdndPDKNSNSENLFTSeglqpsyadlnKIfDNSDDNSNDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.82|      67|     585|    2077|    2152|      11
---------------------------------------------------------------------------
 2077- 2149 (100.18/75.46)	DSGLYLSLAASC.....HFN.ENLTTIVERyEHeiTGMAKDPSNFkkrSLLSLLLKQRQQ..NKFNQHQNDD...DSKQQQQND
 2173- 2250 (96.64/50.26)	QCTLFHNSSNSVqraikHLNqEKYSPIIAN.KH..VNILEYIDAF...DIVTLALEQGRYvfERFDGYNNRQlyiPNQQQQQKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     818.22|     203|     376|    2315|    2564|      12
---------------------------------------------------------------------------
 2315- 2522 (346.33/215.59)	LWDAPYAvrGPLTWREFHRLAGRGIGQCE.PQPVPSVV...VGHDKEWLCVsPYALQFWDKLLLEPYSHPRD..IAYIV.VSPDNHFITSRVKMFFKELSTTYE.M.CRLG.RHQPVKEWEGIL.RVGKSVVKQENNNF....DDDWLQSSLD....SNKLNELLR....LYGI....AFQQSLVGFLSKIPydKTLLNPPENCYNNHNSYKDHHHHHSHQRPSSLSSPMLPPHT
 2706- 2904 (287.48/162.41)	LYTPPYI....LSTRNAKSENVENFGQSGiEQQCSSIM.........YCC...YCLSEDQSMLLAVLTDERGefLENCT.INIDVPNRKRRKKTSARRIALQKL.MdFILGvMSQTVKPWRLVIgRIGR.IGHGELKGW......SWLLSKPNlvkaSKYLKDICK....QCSV....MYPQSVPSIWSAC...LVTLEPDSNFRVMPDQFTPDERFSQRSTQSPLSTPQDVSCT
 2964- 3122 (184.42/147.42)	V.GIPQA..SPT..RDSHRGSPLTLDENK.SRQSPGMTdnqTGQSRNIYSM.PEAEEV.GQLLQQPLA......LGYLVsTAP.....TGRMPSWFWACCPHLEsV.C.......PV.FLKTAL.HIHSPSIHKENDDIyykeQSSKIEHPLD....SNTTADVLRyvleGYNVlswlAMDSNTHDRLSCLP...........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      17|      33|     477|     493|      13
---------------------------------------------------------------------------
  477-  493 (31.17/20.19)	AYMHIQHYEMNEAVNVL
  512-  528 (29.56/18.73)	ALIHHENREYEEAVKIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.43|      42|      59|    1494|    1535|      14
---------------------------------------------------------------------------
 1274- 1300 (34.06/12.45)	........IEKS..DPTTWN.........FvEPNHKSNCLCTRCKN
 1494- 1535 (72.49/35.53)	DNSQTNHQANNN..DGGSIDNGNNTKID.F.KSNNNSKQKLTDTNN
 1553- 1594 (59.89/27.97)	DISEEDHSISQSlyDYSTWDAWMNHPIKrF.KPDDLDRNR...SNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.96|      24|      33|     370|     393|      15
---------------------------------------------------------------------------
  370-  386 (21.42/ 9.72)	................PSVRRSSRI..FSNYSVKE
  387-  421 (26.20/13.94)	NNKSPNLnkfvqprspPSKKANKRVskSSKTTLNE
  423-  440 (22.33/10.52)	NEKNNML.........SEKERSETI..TS......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.91|      22|      34|     849|     882|      16
---------------------------------------------------------------------------
  849-  872 (33.58/46.39)	GASLED....CHTNFFALADLCgIkWKK
  883-  908 (37.32/16.73)	GDPLDDpvlrSYTKCLAKDILC.V.WRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.90|      32|      52|    1188|    1221|      17
---------------------------------------------------------------------------
 1188- 1221 (47.94/34.09)	NKKIINSSETKSSYRcSEIDK......DCIESSVlNFCDG
 1236- 1273 (48.96/25.62)	QDSIMNPAYTNASVK.SEQEKiemqseNNIENSI.NAANG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.62|      28|      32|    1115|    1146|      18
---------------------------------------------------------------------------
 1119- 1146 (53.08/40.51)	NYEQYTEKIVNDWNNFYPMKK.LDGDNSS
 1148- 1176 (44.54/23.31)	NMPQLVEVISGGIKMLYPSKYvLVTDILS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.53|      19|      22|     252|     270|      21
---------------------------------------------------------------------------
  252-  270 (35.83/21.41)	PYRKQFKYLQSNMIPITPS
  275-  293 (33.70/19.64)	PLNSPFDSLKQTTLFLTPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10856 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADLNKIFDNSDDNSNDDHLVDNTPPGSNKSIGCHPA
2) AVGIPQASPTRDSHRGSPLTLDENKSRQSPGMTDNQTGQSRNIYSMPEA
3) DKFDSVIRSHQQPEQSEGIPLREDFVEDDDVSDDEAAPGNDNDNNNSSGTIEESDITMTHQNHQT
4) DSIFRKTMVGIGMPMSSSHHSQPPPPYDVAIHSPSLNSNLNSISSNNDENKQKILSNNNNIKGNHPHHPQHHFMTQQQQQHQLQQHQQQSLNGQKT
5) KQTTLFLTPSPPLTTQQQTQQQQQQIIDCEKNNSNKKIRGNLNSLVTRKEI
6) LNPPENCYNNHNSYKDHHHHHSHQRPSSLSSPMLPPHTPDSSMSANGSNNNNNNMSSMSHHDKGPNTPKSDQDDTKENLNNSTSTSEIMSQQLD
7) SLKTPGNSSSISGKSNFRNNSNRNRTPFHKRYKKLLH
8) SSLSKSKERFSNQPSTSSKFNIRSSVKQSSGGSGSNGGNASQTQNSNNTNEVQQMSIGSDGSIQSPMHHNLSSVHSQPSSVPVNEQNILSPIPPSDVSPPSMTPSLENNIDQKPDIQSLNNFDKTTDNSQTNHQANNNDGGSIDNGNNTKIDFKSNNNSKQKLTDTNNKENI
9) SVLPNLVQQIQNLNESGKIDDAKNNLNNNCGKDNRNVNGGNCVGGGSGGVDNDPDKNSNSENLFTSEG
10) SWIKQKEQDEVRKKQQQLQADNNGSLMIKKEIINPPPLPEPPSIEIKKEVMS
11) TPLQQTKPVVLNQSSNITPNRTQFMQQQQQDQRYPSVRRSSRIFSNYSVKENNKSPNLNKFVQPRSPPSKKANKRVSKSSKTTLNELNEKNNMLSEKERSET
12) VGSTIINKLLTQGPTPPPNVFKSSIHSSMGSPSPANLQTNNYISPYPPMSH
1686
2963
783
1935
284
2485
1309
1368
1613
1809
336
1883
1721
3011
847
2030
334
2578
1345
1539
1680
1860
437
1933










Molecular Recognition Features






MoRF SequenceStartStop




NANANA