<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10832

Description Uncharacterized protein
SequenceMMAPQPLEQGLAAGYLPQGTEGSPRMNTISLAVLIDFIIQRTYHDLTVLAELLPRKSDMERKIEIYNFAARTRQLFIRLIALVKWANSVSKVDKSANIMSFLDKQNMLFVETADMLARMSRETLVRACLPNFHIPAAVEVLTKGTYNRLPTCIRERIVPPDPITIQEKRQTLLRLNQVIQHRLVTGKLMPQLREFKIRNGRVTFEVKHEFKVSLTVMGDSPTVPWRLLDIDVLVEDKETGDGKALVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNIQVEEYIPGVKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHIPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLDFQAFLKDVDFNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIIPEMQACLNGDRNKLPHIMSELRYWITHRRCEKTLQHLPATATETLPFLKAPDNPLLQAGRHKIFVKLHRHPSVILVVQLKEKPNTPNEMEYTFHLGFVAFQTKENDSTADESPQQLVPVQAPPSQQGAASTPNAEVPRVYTKLLKLIEFDTFVSTHGPGTDVDDTPPHKRKSINEHGAPAAKQAKTIYPAYFIPELAHVVAMCDEKIPFLNLAQALTKHNIPHSGLQVESNATSLVLKILALPKPGPSGEDNKQQPHIPNMPTIEPHVWKDLMKRLLSISIRSQMNKNNQIRVWVVEFVFFSTPLQSTHAKEQGNRRTVYLTYEQINHDFSKTVDDLLKDWSKIVYLYTLAYNFSEHIKNKRLNISDMISINSYNYINLLLGYGPKKEVICNIYWSAQSHGFRLIFMGGITTVNSHSMMRDQLTTHLNSQHSLAQLVCILHETYNPLSSIAKLPIIPHLGIPRPLVPVLSFCILPQSPCLIRLAYQAMFCLEIRFRSGRLVSIRDGAFSRFDRNLIDEFTPIQGLKGFLSKYVDENAVYRGRSQSEDDNPPSPLGMEDNFGGPGSVPGGGTGGSSPFLSAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPGSGTSTGAGSGQNHPNYNLTSPPGPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNAGSLYMQGHQDSPFAAMSPANSNWPGSPSMPRPSPRPGQSPDHKSSQSGNTGSNSAGCNSGNPQGMNRMPQANRSWAGAIPTVLTHEKLDLLCRPSPHPNKEIGATPDISPLERFLGCVYMRRQLHRNIQNDDTLQVLNSNEPGVVLFKVDGLQCQVTLNQIHMQSLHLKIAPLPPQPTQDGKQPFQLSPDDLLVLEQFFDTRVAAPPYRPNSLHSFCRVLSCATQVLKDFVQIMRLEMKPDLGGEQFKWTVQFCTRVPPSAAPIVPIGSPGVLIVRLKILFFLQVTRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQVQSPAAQTASSLLRRFSECAVHGQCSLFPAVRDLLINLQLPNDVPPPNQLIGPPVGPMVGSSPNPMMHSPMQQMGGPVGPPHVGPGYQQMPQNPGPQ
Length1547
PositionTail
OrganismStomoxys calcitrans (Stable fly) (Conops calcitrans)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Stomoxys.
Aromaticity0.07
Grand average of hydropathy-0.313
Instability index51.84
Isoelectric point8.78
Molecular weight172377.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10832
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     389.32|      69|     152|     992|    1071|       1
---------------------------------------------------------------------------
 1001- 1041 (64.61/29.06)	....................................SEDDNP.P..SPLGMEDNFGGPGSVPGGGTGGSSPFLSAGM.RGP
 1042- 1093 (89.58/36.59)	QSPRDSGLrfPAPHTP.PSSSN..PHTPASPHP.......................GSGTSTGAGSGQNHP..NYNL.TSP
 1094- 1136 (58.94/18.82)	..........PGPHMPhPSPSGlmP...........SSPLNPqP..SPHMVHS........PGPNAG..SLY....M.QGH
 1137- 1197 (91.46/33.90)	Q...DSPF...AAMSP.ANSNW..PGSPSMPRP.......SPrPgqSPDHKSSQSGNTGSNSAGCNSG.NP...QGMnRMP
 1489- 1541 (84.74/30.86)	QLPND.........VP.PPNQL..IGPPVGP..mvgSSP.NP.......MMHS....PMQQMGGPVG..PPHVGPGYqQMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.77|      40|      83|     419|     460|       2
---------------------------------------------------------------------------
  419-  460 (71.17/54.22)	TVPVL....TPCLRA..EQIHITIDTHTG.MLRCHVPKHLDCPiiPEMQ
  500-  546 (55.60/35.42)	TLPFLkapdNPLLQAgrHKIFVKLHRHPSvILVVQLKEKPNTP..NEME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     281.09|      88|     370|     841|     984|       3
---------------------------------------------------------------------------
  841-  949 (133.77/165.35)	PKKEVICNIYWSAQSHgfrliFMGGIttvnshsMMRDQLttH...........LNS............QHSLAQLVCILHETYNPLSSIAKLPIIPHLG.............I.P...RPLVPVLSFCILpqspcLIRLayQAMFCLEI
 1226- 1305 (73.39/27.76)	PNKEIGATPDISPLER.....FLGCV.......YMRRQL..HrniqnddtlqvLNSnepgvvlfkvdgLQ..CQV.........TLNQIHMQSL..HLK.............IaP...LPPQP..........................
 1339- 1413 (73.94/23.74)	......................................................NS............LHSFCRVLSCATQVLKDFVQIMRLEMKPDLGgeqfkwtvqfctrV.PpsaAPIVPIGSPGVL.....IVRL..KILFFLQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.19|      82|     342|     309|     416|       5
---------------------------------------------------------------------------
  223-  307 (133.21/98.71)	VP.WRLL...DIDVLVEDKET..GDGKALVHPLQVNYIHQLiQARlvENPNALSEVYNCLHYFCQSLQLEVLYTQTL.RLSYERLDDNI...QVE
  317-  408 (112.99/114.58)	VSyWRELtskDPKSELGYRLTvqSDPNEIGRPLAVVHIPSL.GAK..ESAEVADRAVRSDHLSMERLIVHTVYIRSVsRLSDLKLDFQAflkDVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.16|      12|     374|     126|     139|       8
---------------------------------------------------------------------------
  126-  139 (19.03/13.94)	RACLPnfHIPAAVE
  467-  478 (20.12/ 8.38)	RNKLP..HIMSELR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10832 with Med14 domain of Kingdom Metazoa
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