<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10831

Description Uncharacterized protein
SequenceMMAPQPLEQGLAAGYLPQGTEGSPRMNTISLAVLIDFIIQRTYHDLTVLAELLPRKSDMERKIEIYNFAARTRQLFIRLIALVKWANSVSKVDKSANIMSFLDKQNMLFVETADMLARMSRETLVRACLPNFHIPAAVEVLTKGTYNRLPTCIRERIVPPDPITIQEKRQTLLRLNQVIQHRLVTGKLMPQLREFKIRNGRVTFEVKHEFKVSLTVMGDSPTVPWRLLDIDVLVEDKETGDGKALVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNIQVEEYIPGVKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHIPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLDFQAFLKDVDFNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIIPEMQACLNGDRNKLPHIMSELRYWITHRRCEKTLQHLPATATETLPFLKAPDNPLLQAGRHKIFVKLHRHPSVILVVQLKEKPNTPNEMEYTFHLGFVAFQTKENDSTADESPQQLVPVQAPPSQQGAASTPNAEVPRVYTKLLKLIEFDTFVSTHGPGTDVDDTPPHKRKSINEHGAPAAKQAKTIYPAYFIPELAHVVAMCDEKIPFLNLAQALTKHNIPHSGLQVESNATSLVLKILALPKPGPSGEDNKQPHIPNMPTIEPHVWKDLMKRLLSISIRSQMNKNNQIRVWVVEFVFFSTPLQSTHAKEQGNRRTVYLTYEQINHDFSKTVDDLLKDWSKIVYLYTLAYNFSEHIKNKRLNISDMISINSYNYINLLLGYGPKKEVICNIYWSAQSHGFRLIFMGGITTVNSHSMMRDQLTTHLNSQHSLAQLVCILHETYNPLSSIAKLPIIPHLGIPRPLVPVLSFCILPQSPCLIRLAYQAMFCLEIRFRSGRLVSIRDGAFSRFDRNLIDEFTPIQGLKGFLSKYVDENAVYRGRSQSEDDNPPSPLGMEDNFGGPGSVPGGGTGGSSPFLSAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPGSGTSTGAGSGQNHPNYNLTSPPGPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNAGSLYMQGHQDSPFAAMSPANSNWPGSPSMPRPSPRPGQSPDHKSSQSGNTGSNSAGCNSGNPQGMNRMPQANRSWAGAIPTVLTHEKLDLLCRPSPHPNKEIGATPDISPLERFLGCVYMRRQLHRNIQNDDTLQVLNSNEPGVVLFKVDGLQCQVTLNQIHMQSLHLKIAPLPPQPTQDGKQPFQLSPDDLLVLEQFFDTRVAAPPYRPNSLHSFCRVLSCATQVLKDFVQIMRLEMKPDLGGEQFKWTVQFCTRVPPSAAPIVPIGSPGVLIVRLKILFFLQVTRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQVQSPAAQTASSLLRRFSECAVHGQCSLFPAVRDLLINLQLPNDVPPPNQLIGPPVGPMVGSSPNPMMHSPMQQMGGPVGPPHVGPGYQQMPQNPGPQ
Length1546
PositionTail
OrganismStomoxys calcitrans (Stable fly) (Conops calcitrans)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Stomoxys.
Aromaticity0.07
Grand average of hydropathy-0.311
Instability index51.74
Isoelectric point8.78
Molecular weight172249.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10831
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     351.13|      56|      56|    1047|    1102|       1
---------------------------------------------------------------------------
 1008- 1045 (49.37/15.48)	...............PLGMEDNF...GGPGSVPGGGTG.GSSP.FLSAGM.....RG.PQSPRD..
 1047- 1102 (111.21/44.52)	GLRFPAPHTPPSSSNPHTPASPH...PGSGTSTGAGSG.QNHPNYNLTSP.....PG.PHMPHPSP
 1104- 1160 (82.41/31.00)	GLMPSSPLNPQPS..PHMVHSPG...PNAGSLYMQGH..QDSP.FAAMSPansnwPGsPSMPRPS.
 1161- 1200 (49.65/15.62)	...............PRPGQSPD...HKSSQSGNTGS...NSAGCNSGNP.....QGmNRMPQANR
 1503- 1546 (58.49/19.77)	...PVGPMVG.SSPNP.MMHSPMqqmGGPVGPPHVGPGyQQMPQ.N.........PG.PQ......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.49|      64|     370|     840|     983|       2
---------------------------------------------------------------------------
  883-  947 (111.31/120.46)	NSQHSLAQLVCILHETYNPLSSIAKLPIIPHLGiPRPLVPVLSFC.........ILP.QSPCLIRLAYQAMFCLE
 1338- 1411 (102.19/38.33)	NSLHSFCRVLSCATQVLKDFVQIMRLEMKPDLG.GEQFKWTVQFCtrvppsaapIVPiGSPGVLIVRLKILFFLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     519.86|     173|     204|     182|     367|       3
---------------------------------------------------------------------------
  182-  354 (241.68/177.54)	....................................RLVTGKLMPQlrEFKIRNGRVTFEVKHEFKVSLTVMGDSPTVPWRLL...DIDVLVEDKETGDGKALVhPLQVN.YIHQLIQARLVEN....PNALSEV.YNCLHYFCQSLQLEVLYTQTLRLSYERLDDN..IQVEEYipgvKITVSYWREltskdPKSELGYRLTVQSD.PNEIGRPLAVVHI
  356-  554 (246.15/154.36)	SLGAKESAEVADravrsdhlsmerlivhtvyirsvsRLSDLKL.....DFQAFLKDVDFNLQGTPAI.LTVPVLTPCL..RAE...QIHITI.DTHTGMLRCHV.PKHLDcPIIPEMQACLNGDrnklPHIMSELrYWITHRRCEKTLQHLPATATETLPFLKAPDNplLQAGRH....KIFVKLHRH.....PSVILVVQLKEKPNtPNEMEYTFHLGFV
  555-  615 (32.03/ 7.13)	AFQTKENDSTAD....................espqQLVPVQAPPS................QQGAAS.TPNAEVPRVYTKLLkliEFDTFVSTHGPG...........................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.55|      15|      24|    1204|    1219|       4
---------------------------------------------------------------------------
 1204- 1219 (22.63/17.86)	GAIPTVLTHEKLdLLC
 1230- 1244 (28.93/17.76)	GATPDISPLERF.LGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.38|      28|      30|    1277|    1304|       5
---------------------------------------------------------------------------
 1277- 1304 (53.61/28.24)	DGLQ.CQVTLNQIHM..QSLHLKIAPLPPQP
 1307- 1337 (40.77/19.68)	DGKQpFQLSPDDLLVleQFFDTRVAAPPYRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10831 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ENDSTADESPQQLVPVQAPPSQQGAASTPNA
2) PPNQLIGPPVGPMVGSSPNPMMHSPMQQMGGPVGPPHVGPGYQQMPQNPGPQ
3) YRGRSQSEDDNPPSPLGMEDNFGGPGSVPGGGTGGSSPFLSAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPGSGTSTGAGSGQNHPNYNLTSPPGPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNAGSLYMQGHQDSPFAAMSPANSNWPGSPSMPRPSPRPGQSPDHKSSQSGNTGSNSAGCNSGNPQGMNRMPQANRSWAGAI
560
1495
994
590
1546
1206










Molecular Recognition Features






MoRF SequenceStartStop




NANANA