<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10827

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQSHQTNGASLEDCHTNFFALTDLCGIKWRKFVNSERPNASSDPLDDPILRSYSRCMQADILCVWRRVQSTRQDNSDPNNFDVVNTSKVHPPLSLAAAKELWLFWYGEEPDLTDLVDADLLKVAGNQMLWNGTWERGLTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAAASNANSPEQTSPNSPNGGGEGVKENAAAGTTIAANNAKCNSLTNNNINGSGNGNTNNNANTSGNSNGGHLKPRKVILAPFGMAATLTGNSYKENDPMAEKILEDWVSFFPLCNKENNDVPPVVEVIAGGHKMYHPSIYVLVTDLDDMEEMEEMEAVASQKSSLGSSSSAGAAAIAALSSAANQGGGGGTNDASNIEAKPPLVENVGNSKLSASASANNNTTSTTKSSLAHMIERLKIDHTKVQPYYDTQTRNFTCNTTNTHAPPQAACEMPERAWQDCITNALHIEHTLNDTILSSTNTTSTSSSSLAPTNTNTNTTTSASPNNTNTTSGGGSGNENTSANNAEGSADQTDSNNADIKPNLIANVSQKQQQQQQTWGFIDPTQKAPCICTKTTQAASSGQTPGNGTPLQGGVSSYSRNSMMDCMPIPSVGSPGTPAPSPHPNSALSQPTSVPPADQMLMSPRAPTSVPNLQQPTTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHPAPSCEAPLSVEGMHGMGGGMGPGSVGPQPPSVGRCTPTIHPQQSSLPPQAQQCGSISVKKFDVQPGTPLLLGASNNNCSSVVQGGLPPSDSKMESVAMPTSAATALPNNNFNKCNTVQSAANAMNEFWKLYKPPQITVKDIDTFANDDCLKLDVLYDFTIQNAWANHPVKRFKPNEISKQCRVLRTKTLYEGHTHIKPLMPSPRSIYGDRLLAIDPTAAALASATGSKSNMEGIGVSGMGSGGLVGIASNAMGNNQMTNNSNINDTPSVNIGNSETAAGGSIFEELDIKTEVASAVGASSTSPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECGSVQIHTPPDSNNPSNGCAITTNTIEELKRSTNSVLVGAAVSVQGSNAAVIAAIQNCNNVSNTTNTSGLASLNNSAGSMSGVGGGNSGANTIQVEDLTKMFPTPPSHEQHHPNSSPCQMDIQMNDISVITPANMLSQTLDTGLGISAMVKVKQEYSVELGSPVEQPIEDWSYVFKPPAQAKFEGSSKYAPLTNLPSQSLAPLVMPTNCRYKPSWQQPRNTHQQQQQQQQQQHQQHMQQQQQQQQHLQQQQHHQQLHELLSAAPRTPLQQPRTPLGPMSSSPMHTTVPTPLSSGGGGVGGSSLLLNQLNCPQAALTNTPPTMQQLMQRTGMSPISPANHVPFPHTSPMMQQHRQTPIHPPPPYEVAVASPALSTASSTPAYLNKQYHSQEPPQTPQSVNNHMQTIGGPPSVQGNNRDASNSGFYAPTNNTNSILQELPEVSSVIVNILLYDTALNVFRDHNFDSSTVCVCNADNQRIGNIRGSDSGVYVPLPGTTFNPTSPSLSTSNALRALSAFGSVVGSCGIAGGALGAVGGIANSLDSPASIAGAGSSSSTTPSTATPANNNAQQYITGYVDDDAVECTCGFSAVINRRLAGKAGLFYEDEMEITGIAEDPGRHKKHSLLTLITTLTSKANNNNNNSNANNNNAISNASSSIIDKSSEQIAFAIFDLLLEQCSIIQTSSSAIHRALQRHRRKLSKKSQKPQSVAAIVNILEYIDANDIVALALEQARLAFDSNRMDIMEQQMVSFSSHRKTSNNIQVALALTGRLNVHKWPYIPVGFSRSNKDIVSTMKSIQPMLQNAFHAKSRTAAGSRDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDVVYLVIAPDNDFILSKTKTYFKELSTTYEMCKLGRHTPICGWNGLLSVQQRPASEKPFTTSMDNWLKTLEDSKLAEEMRLYAYAFQHQLAPYLSRVPNDKTLLNPPENHSRCNQGYSTSTSASSAFSSSSTSTASSSFMSGGGNNSNTTGTDNVPHGTNASSGDHSQPADNNEHSQHATTSNSTDSQTNAPEAKPADIKPDVKPPLILGDPLGVAECLEEINPSAIVLYVVEPFTFRSDSPELERIACIALLRMYIELLKMIPDSVRSHINIQIISLESILELGRSRNRKRFSDEIKCLALNIFSQCKRHMVHAQAVKSLTGFGTAANVEAFLKTKDDKNRKAYKMYTPPYILAPMHEKNEKTDFSRAAWGGMRGSPNDQKYSVMYCNYCLSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRRAPARRIGLNKLMDYILGLISQTTQTWRLVVGRIGRIGHNELKSWSYLLGKQNLQKATKQLRDMCKQCQLINPPTILSACLVTLEPDAKLRVMPDQFTPDERFSIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFPNEPQVDLDEDFINFGNDEDENEVFKDADLDDLLGTWDNGGTGRGMSNHNSPDRMEDNRSWQSVGGNNFNSNQHQDIEEVGQINQQPLAVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPNIQITDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIT
Length2726
PositionMiddle
OrganismStomoxys calcitrans (Stable fly) (Conops calcitrans)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Stomoxys.
Aromaticity0.06
Grand average of hydropathy-0.458
Instability index48.52
Isoelectric point5.94
Molecular weight294767.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10827
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.23|      15|      15|    1301|    1315|       1
---------------------------------------------------------------------------
 1301- 1315 (33.80/19.69)	HQQQQQQ..QQQQHQQH
 1318- 1334 (28.43/15.47)	QQQQQQQhlQQQQHHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.97|      15|      23|     678|     698|       2
---------------------------------------------------------------------------
  691-  713 (10.44/ 8.26)	LMSPRApTsvpnLqqpTT..PIDHL
 1387- 1403 (22.53/ 9.17)	LNCPQA.A....L...TNtpPTMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.58|      15|      20|    1412|    1428|       3
---------------------------------------------------------------------------
 1412- 1426 (30.50/18.54)	PISPANHVPFPHTSP
 1435- 1449 (30.07/11.03)	PIHPPPPYEVAVASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.81|      13|      20|    1733|    1745|       4
---------------------------------------------------------------------------
 1733- 1745 (22.26/14.52)	SIIDKSSEQIAFA
 1755- 1767 (22.56/14.84)	SIIQTSSSAIHRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     116.74|      24|      24|     523|     546|       5
---------------------------------------------------------------------------
  466-  498 (23.57/ 7.43)	ERlkidhtkvqpyYDT....QTRNFTCNTTNTHAPPQ
  521-  544 (37.19/16.81)	TL...........NDTIL..SSTNTTSTSSSSLAPTN
  545-  570 (31.23/12.70)	TN...........TNTTTsaSPNNTNTTSGGGSGNEN
  571-  592 (24.75/ 8.24)	TS...........ANNAE..GSADQTDSNNADIKP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.55|      25|      25|     738|     762|       6
---------------------------------------------------------------------------
  738-  762 (48.65/24.33)	VHPAPSCEAPLSVEG.....MHGMGGGMGP
  765-  788 (31.58/12.93)	VGPQPP.....SV.GrctptIHPQQSSLPP
 1466- 1488 (39.32/18.10)	.HSQEPPQTPQSVNN......HMQTIGGPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.46|      23|      26|     103|     128|       7
---------------------------------------------------------------------------
   80-  111 (25.87/26.75)	PNNFDVVNTSKvhppLSLAAAkeLW.LFWygeE
  112-  137 (33.59/23.00)	PDLTDLVDADL....LKVAGNqmLWnGTW...E
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.97|      15|      19|     826|     843|       8
---------------------------------------------------------------------------
  826-  843 (21.33/21.10)	LPPSD.SKMESVampTSAA
  846-  861 (23.64/12.38)	LPNNNfNKCNTV...QSAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.97|      16|      19|    1606|    1622|       9
---------------------------------------------------------------------------
 1606- 1622 (21.88/12.51)	GAlGAVGGIANSLDSPA
 1626- 1641 (25.47/10.83)	GA.GSSSSTTPSTATPA
 1642- 1657 (25.62/10.94)	NN.NAQQYITGYVDDDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.34|      14|      20|    1345|    1358|      10
---------------------------------------------------------------------------
 1345- 1358 (27.63/15.76)	TPLQQPRTPLGPMS
 1368- 1381 (24.71/13.07)	TPLSSGGGGVGGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.07|      20|      20|     388|     407|      11
---------------------------------------------------------------------------
  388-  407 (29.93/14.68)	AVASQKSSLGSSSSAGAAAI
  409-  428 (33.14/17.13)	ALSSAANQGGGGGTNDASNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.08|      20|      20|     975|     994|      13
---------------------------------------------------------------------------
  254-  273 (32.74/19.54)	GVKEN.AAA.GTTIAANNAKCN
  276-  297 (22.55/10.46)	TNNNInGSGnGNTNNNANTSGN
  975-  994 (33.78/20.47)	GVSGM.GSG.GLVGIASNAMGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.79|      16|      24|    1875|    1890|      16
---------------------------------------------------------------------------
 1875- 1890 (28.39/20.43)	PMLQNAFHAKSRTAAG
 1901- 1916 (30.39/22.53)	PLTWRQFHRLAGRASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.65|      19|      24|     598|     616|      17
---------------------------------------------------------------------------
  598-  616 (36.27/22.17)	VSQKQQQ...QQQTWGFIDPTQ
  621-  642 (30.37/17.06)	ICTKTTQaasSGQTPGNGTPLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.34|      17|     572|     432|     448|      18
---------------------------------------------------------------------------
  432-  448 (29.12/15.31)	PPLVENVGNSKLSASAS
 1007- 1021 (26.49/13.21)	PSV..NIGNSETAAGGS
 1030- 1042 (19.74/ 7.82)	TEVASAVGAS....STS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.68|      25|      26|    1158|    1182|      20
---------------------------------------------------------------------------
 1158- 1182 (43.10/25.67)	SMSGVGGGNSGAN.TIQVEDLTKMFP
 1186- 1211 (42.58/25.26)	SHEQHHPNSSPCQmDIQMNDISVITP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10827 with Med13 domain of Kingdom Metazoa
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