<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10816

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDWQSQKFRQNVIAKINEMLQNTNQDGSKNAGVMENHIFKKSKSKDEYLGLVAKLFMHFKDMSRRPQQAPPPNVEIPQQNMMQDPLNALQNLASQGNRNPQMMSMPGGPNAQQGGGPGGPVPASNLLQTLNQQRPGMQPMQVIRPQMAMGAVGPGQQQGNIGPGQQQMMAGPMGVQMNAMGGPAGGPNQQMVNSAQMGGPVVGSGGVGVGPGGPQGMPGQMNQMGGPGAIGSMGPNVGPGGPNQMQMSMQHPQLNQMINARMNQAGPGGPMNVAGHTGPNQGMQNMPPNMQQNQAGVGGSGGPMHMGNIGPGNAPQNQGPGGMANAPGPQGNLNQMLNMAPGMQKNPNIALGQGQQIFNVNRGVVGQQQFRQSPSPSTVASPAGNLNVQQQQQLQQQVVNNQQQQMQQQPNQAVGPQGALPNPQMIPSPALVPTSSPQMSGLMQNPNQRQQMRQSPSAPLNTPGQVAQNSPFNPQEDQLYREKYKQLTKYIEPLKRMVDKLSNDGNNAEGYRKMNKLLEILTNPSQRVPLETLLKCEKVLENMGINSYSGQTFGKSSNPLMEVISATLQSPLANHTLYRTFRPSLELLFGTDICAPPAKMAKPAEKPSTGDLDIPHVLQGEVARLDQKFKVSLDSSAQNNVKSIRLICRLDDEKLPWVPPVSINIPEDYPWSSPECSLIEQDYSATPFLNAVQNALIARIAKLPKLHSLSHLLDTWEMSVRQACSPNAVKPVCEFTALFGM
Length743
PositionTail
OrganismStomoxys calcitrans (Stable fly) (Conops calcitrans)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Stomoxys.
Aromaticity0.04
Grand average of hydropathy-0.611
Instability index55.61
Isoelectric point9.27
Molecular weight79797.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10816
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     227.48|      32|      32|     259|     290|       1
---------------------------------------------------------------------------
  170-  202 (36.56/ 8.01)	MM......A.GPM.....GvQMNAMGGpaGGPNQQMV.NsaqMgG...P
  226-  254 (37.66/ 8.52)	M.......G.GPGaigsmG.P.NV.GP..GGPNQ.MQmS...M.Q..hP
  259-  290 (71.04/23.90)	MINARMNQA.GPG.....G.PMNVAGH..TGPNQGMQ.N...M.P...P
  315-  343 (47.13/12.88)	..NAPQNQ..GPG.....G.MANAPGP..QGNLNQML.N...M.A...P
  407-  435 (35.08/ 7.33)	QMQQQPNQAvGPQ.....G.AL.........PNPQMI.P...S.PalvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.08|      29|      32|      66|      94|       2
---------------------------------------------------------------------------
   68-  101 (46.56/15.47)	PQQAPPPNVEIPQQNMMQDPLNALQNL...asqgnRN
  439-  475 (45.52/14.95)	PQMSGLMQNPNQRQQMRQSPSAPLNTPgqvaqnspFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.59|      19|      32|     351|     371|       3
---------------------------------------------------------------------------
  102-  118 (32.87/ 9.44)	PQMMSMP...GGP..NAQQG..GG
  147-  167 (31.42/ 8.66)	PQMAMGAvgpGQQQGNIGPG...Q
  349-  369 (24.29/ 8.95)	PNIALGQ...GQQIFNVNRGvvGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.84|      15|      16|     509|     523|       5
---------------------------------------------------------------------------
  509-  523 (25.37/13.20)	NAEGYRKMNKLLEIL
  576-  590 (22.47/10.99)	NHTLYRTFRPSLELL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10816 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FKDMSRRPQQAPPPNVEIPQQNMMQDPLNALQNLASQGNRNPQMMSMPGGPNAQQGGGPGGPVPASNLLQTLNQQRPGMQPMQVIRPQMAMGAVGPGQQQGNIGPGQQQMMAGPMGVQMNAMGGPAGGPNQQMVNSAQMGGPVVGSGGVGVGPGGPQGMPGQMNQMGGPGAIGSMGPNVGPGGPNQMQMSMQHPQLNQMINARMNQAGPGGPMNVAGHTGPNQGMQNMPPNMQQNQAGVGGSGGPMHMGNIGPGNAPQNQGPGGMANAPGPQGNLNQMLNMAPGMQKNPNIALGQGQQIFNVNRGVVGQQQFRQSPSPSTVASPAGNLNVQQQQQLQQQVVNNQQQQMQQQPNQAVGPQGALPNPQMIPSPALVPTSSPQMSGLMQNPNQRQQMRQSPSAPLNTPGQVAQNSPFNPQEDQLYREKYK
2) NVIAKINEMLQNTNQDGSKNAGVMENHIFK
61
13
487
42










Molecular Recognition Features






MoRF SequenceStartStop




NANANA