<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10814

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMNNYSNMMMGEQFRKMDSNYSPKSSPHGGRSPVVSRQDSSGTLKATISLGKTPTIIQTGPFYSMKEPPGKGELTGDKDLMTEYGLHHTLTKFKDKKVKESLSSFLPNLPGIYDGMNNLENSTLRSVIDKPPIGGKELLPLSSVQLAGFRLHPGPLPEQYRAFNTIPARKHKNKHKKHKHKDGQQPPETNLMDSSGLETYEKKHKKQKRHEDEKERKKRKKEKKRKKKSHSPEPPSSGGVSPMLGGPSQQGGMMGMSMQGGSMGSLQGLTTGPNNPLGPGSGVTNMSGPGGMMMPQHASLF
Length301
PositionHead
OrganismStomoxys calcitrans (Stable fly) (Conops calcitrans)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Stomoxys.
Aromaticity0.05
Grand average of hydropathy-0.997
Instability index56.41
Isoelectric point9.94
Molecular weight33006.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10814
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.57|      13|      20|     201|     213|       1
---------------------------------------------------------------------------
  172-  183 (23.19/ 9.12)	KNKHKKHK.HKDG
  201-  213 (25.31/10.45)	EKKHKKQKRHEDE
  222-  233 (22.07/ 8.42)	EKKRKK.KSHSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.50|      13|      45|     235|     247|       2
---------------------------------------------------------------------------
  235-  247 (26.06/10.78)	PSSGGVSPMLGGP
  261-  273 (23.01/ 8.76)	GSMGSLQGLTTGP
  279-  289 (22.43/ 8.37)	PGS.GVTNM.SGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.24|      14|      14|      65|      78|       3
---------------------------------------------------------------------------
   60-   75 (22.54/11.73)	GPFysMKEPPGKGELT
   76-   91 (21.70/11.00)	GDKdlMTEYGLHHTLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10814 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQFRKMDSNYSPKSSPHGGRSPVVSRQDSSGTLKATISL
2) LPGIYDGMNNLENSTLRSVIDKPPIGGKELLPLSSVQLAGFRLHPGPLPEQYRAFNTIPARKHKNKHKKHKHKDGQQPPETNLMDSSGLETYEKKHKKQKRHEDEKERKKRKKEKKRKKKSHSPEPPSSGGVSPMLGGPSQQGGMMGMSMQGGSMGSLQGLTTGPNNPLGPGSGVTNMSGPGGMMMPQHASLF
12
109
50
301










Molecular Recognition Features






MoRF SequenceStartStop




1) KKRKKKSH
2) YRAFNTIPARKHKNKHKK
223
160
230
177