<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10813

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNFTNSVNVSVETTCESKIQEIAYDGTEIYETPPTLSETLTNCAARIDFSKTSLEELKKEEKAAGEEPDKDAQFQPSLWPWDSVRNKLNDALTEVCVLSDVLSIAKDKRYLVLDPVPDPDNDETKPIVQVYSRKKALNQAAQILLSGAERLKNTHTEQRNRNVSDFHIELLRLRQNWRLKKNNNAIIGDLSYRTAGSKYGMSGTFEVTKAEDVVEDDATATTSSTSSGTNNGLQNPSPKNNSSLRVIVPAELQGVAYFKVITQKDQEDLCTATVNLMGHGPNTTQQGGVWQKTIEDAQNVLFCKELFSQLAREAIQLQAPIPHVVIGNQIRATLLPGIQLIISLCHSTTIDSSQPTPVNDHDHDHVLEHSLHQLLREVHHKNSHHPFPHPASGPLGPSKKRMLAGPMAADRQTLVEMTKSQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNAMTSPTMSCVKINIVTHGYDTINRTSLVIHVRERSLKAICRDGRVMHLSYEPQELRDLILCQINSHQISCLLNLARCMAWQVLSNSNHLGIGKVEPLGNASSCLLSSPNSDRMIAVQIRCTQSQMDVKVYIAKSPRQEFFPNPLVPEKFWENLGGHFKEVRFEKIEGKSFLNKMEFLMASLNSNSA
Length647
PositionHead
OrganismStomoxys calcitrans (Stable fly) (Conops calcitrans)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Stomoxys.
Aromaticity0.05
Grand average of hydropathy-0.421
Instability index41.69
Isoelectric point6.65
Molecular weight72488.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10813
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.13|      45|      72|     371|     415|       1
---------------------------------------------------------------------------
  371-  404 (53.85/33.53)	.......................................LHQLLRE..VHHKN..SHHPFPHPASGPLGPSKKRMLA
  405-  477 (55.41/34.72)	GPMAADRQTLVemtksqtileqiiaqaqhifmrkrtqyvLDTLARD..VKDPQivSH..WNAMTSPTMSCVKINIVT
  479-  513 (23.87/10.76)	GYDTINRTSLV.....................ihvrersLKAICRDgrVMHL...SYEP..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.28|      18|      32|     253|     270|       3
---------------------------------------------------------------------------
  253-  270 (31.32/18.99)	QGVAYFKVITQKDQEDLC
  286-  303 (32.96/20.30)	QGGVWQKTIEDAQNVLFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.34|      21|      33|     534|     555|       4
---------------------------------------------------------------------------
  534-  555 (33.04/30.71)	NLARCMAWQVLSNSNHLGIgKV
  570-  590 (36.30/27.45)	NSDRMIAVQIRCTQSQMDV.KV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10813 with Med17 domain of Kingdom Metazoa
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