<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10801

Description Uncharacterized protein
SequenceMMAPQPLEQGLAAGYLPQGQEGSPRMNTISLAVLIDFIIQRTYHDLTVLAELLPRKSDMERKIEIYNFAARTRQLFIRLIALVKWANSVSKVDKSANIMSFLDKQNMLFIETADMLARMSRETLVRACLPNFHIPAAVEVLTKGTYNRLPTCIRERIVPPDPITVQEKRQTLQRLNQVIQHRLVTGKLMPQLREFKIRNGRVTFEVKHEFRVSLTVMGDSPTVPWRLLDIDVLVEDKETGDGKALVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNIQVEEYIPGVKVTVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHIPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIMPEMQACLNGDRNKLPQIMSELRYWITHRRCEKTLQHLPATATETLPFLKAPDNPLLQAGRHKIFVKLHRHPNFILVVQLKEKPNTPNEMEYTFHLGFVAFQTKETDATVDESSQQLVPVHANMNQQSTGNAPNAEVPRVYTKLLKLIEFDTFVSTHGPGTDVDDTPPHKRKAGFEHGAPSAKQAKTIYPAYFIPELAHVVAMCDEKIPFLNLAQALTKHNIPHSGLQVESNATSLVLKILALPKPRKPHSQEQAKGQPHGPTLPTIEPHIWKDLMKRLLSISIRSQMKQNNQIRIWVVEFVFFSTPLQSTHAKEQGNRRTVYLTYEQSNHDFSKTVDDLLKDWSKIVYLYTLAYNFAEHIKNKRLNIADMVSINSYNYINLLLGYGPKKEVICNIYWSAQSHGFRLSFMGGITTVNAHAMMRDQLATHLNNQQSLAQMVCILHETYNPLSSIAKLPIIPHLGIPRPHVPVLSFCILPQSPCLIRLAYQSIYCLEIRFKSGRLVSIRDGAFSRFDRNLIAEFTPIQGLKGFLSKYVDENAVYRGRSQSEDDNPPSPLGMEDNFGGPSSVSGGGTGGSSPFLSAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPVGGGSSGGAGSGQNHPNYNLTSPPGPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANSNWPGSPSMPRPSPRPGQSPDHKSSQSGTAGQNPTGNNPGNSQSLNRMPQANRSWAGAIPTILTHEKLDLLCRPSPHPNKDIGVTPDISPLERFLGCVYMRRQLYRNIQSDDTLQLLNSNEPGVVLFKVDGMQCQVTLNQVHMQSLHMKIAPLPPPPTPDGKQPFQLSPEDFLVLEQFFDTRVAAPPYRPNSLHGFSRVLSCAPQVLKDFVQIMRLEMKPELGGDQLKWTVQFCTRVPPSAAPIVPIGNAGVHIVRLKILFFLQITRIPYNGKEWKDSPSLVLPMVYDLNSNLTQLAEKREQPQSPGAIAASTLLRRFSEYGVPHGQCSLFPAVRDLLTNLQLPNDVPPPNQAIGPPVGPMVGSSPNPIMHSPMQQMGGPVGPPQVGPGYQQMPQNPGPQ
Length1549
PositionTail
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.07
Grand average of hydropathy-0.342
Instability index52.49
Isoelectric point8.96
Molecular weight172782.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10801
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     339.85|      53|      53|    1020|    1072|       1
---------------------------------------------------------------------------
 1020- 1072 (103.09/46.41)	GPSSVSGGGTGGSSP.FLSAGM.RGPQSPRDSGLRFP.APHTP.PSSSNPHTPASP.H
 1076- 1122 (87.10/37.97)	GGSS.GGAGSGQNHPnYNLTSP.PGPHMPHPS....P.SGLMP.SSPLNPQ.P.SP.H
 1128- 1171 (67.93/27.86)	GPNTLYMQG.HQDSP.F..AAM.....SPANSN..WPgSPSMPrPS...PRPGQSPdH
 1174- 1226 (81.73/35.14)	SQSGTAGQNPTGNNP.GNSQSLnRMPQANRSWAGAIP.TILTH.EKLDLLCRP.SP.H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.00|      19|      19|     897|     915|       2
---------------------------------------------------------------------------
  897-  915 (32.70/16.56)	I.LHETYNPLSSIAKLPIIP
  917-  936 (31.30/15.53)	LgIPRPHVPVLSFCILPQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     109.05|      22|      31|    1323|    1344|       3
---------------------------------------------------------------------------
 1323- 1344 (39.97/22.45)	VLEQFFD.TRV..AAPPYRPNSLHG
 1355- 1373 (21.19/ 7.86)	VLKDFVQiMRL.....EMKPE.LGG
 1377- 1400 (28.82/13.78)	KWTVQFC.TRVppSAAPIVPIGNAG
 1410- 1425 (19.08/ 6.22)	FFLQI...TRI.....PYNGKEWK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.67|      21|      31|      57|      77|       5
---------------------------------------------------------------------------
   57-   77 (35.59/22.11)	SDMERKIEIYNFAARTRQLFI
   90-  110 (35.08/21.70)	SKVDKSANIMSFLDKQNMLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.51|      16|      23|    1493|    1512|       6
---------------------------------------------------------------------------
 1493- 1508 (33.23/10.19)	PNDV.PPPNQAIGPPVG
 1515- 1531 (30.27/15.04)	PNPImHSPMQQMGGPVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.85|      17|      23|     134|     156|       7
---------------------------------------------------------------------------
  128-  145 (23.98/ 6.88)	CLPNFhIPA.AVEVLTK.GT
  152-  171 (17.88/17.65)	CIRERiVPPdPITVQEKrQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.31|      13|      23|     671|     683|       8
---------------------------------------------------------------------------
  671-  683 (24.71/11.26)	ALTKHNIPHSGLQ
  697-  709 (25.60/11.93)	ALPKPRKPHSQEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.50|      20|      23|     218|     237|       9
---------------------------------------------------------------------------
  218-  237 (35.01/21.40)	GDSPTV..PWRLLDIDVLVEDK
  240-  261 (29.49/16.83)	GDGKALvhPLQVNYIHQLIQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.67|      11|      23|     534|     544|      10
---------------------------------------------------------------------------
  534-  544 (20.22/13.94)	QLKEKPNTPNE
  557-  567 (18.45/11.98)	QTKETDATVDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10801 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LQLPNDVPPPNQAIGPPVGPMVGSSPNPIMHSPMQQMGGPVGPPQVGPGYQQMPQNPGPQ
2) YRGRSQSEDDNPPSPLGMEDNFGGPSSVSGGGTGGSSPFLSAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPVGGGSSGGAGSGQNHPNYNLTSPPGPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANSNWPGSPSMPRPSPRPGQSPDHKSSQSGTAGQNPTGNNPGNSQSLNRMPQANRSWAGAI
1490
997
1549
1208










Molecular Recognition Features






MoRF SequenceStartStop




NANANA