<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10800

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAALNIKPLTGVGGGTTNLLSNLPATAEKNKQWQRELLMERIRSHSSQHKTFPELSKAMRMGMLEKRYPLDAVEKANLQKCLDNMQHCIKVTSRQGLVERLESLSRQLSLKFSDDSKALFISTDMFYLEILLDSNGSLTDVKVHHESKVEQQSCSELVDCLNRGDFADFTAQLEGFSSIYQLNAESKVKIKAYDAMQAMETDLYNIFQMQNFSKDAAQILQDSAVGIVMQRRGGHPMRLVYFVSPYDLISVESKTLQPITLDTFNNKSIGFSVTVNLEASSANKLQILPTVTLSKDPQTGMDMPAFAPLTQMNSMLLPATFVLRLNKPLPVCYNTLRAMGLCPAAGNENSPSMSTSLESQNKPPVVSNIMSLIIQTASDQQTKTNQKGLFVHLPDQTHCYYFTENKLMKSTLIHSVPFTEPSQVHKILEFLKKMALFYSLLASCVRPQAKVAVDLESTTVLEVNAISFQQISVALQHPYEESMATVEFDLRSGKPQCSIYSISHNYELLSIKLTSIAQKCLSIPVTIRALLKFWDQERMNMFQHNMGGTATTGMGSSGPNISGGAGGAGSGGVGTGNLGNTHTSYGNFNITGGGTNDPGGGGGGGGMQRMSSGSMPGGVNIKLEPNAGNNQQQQRSLVGPNAVGGLLPQMSTASAAAAGYMKYKNPAELKQEDFHESPKSQINTTINANLVAESMAASNLMQSNLEINSLGHHQQTAQQQQQLEQQIAEHEIADKYKNIWKDKTTSLKNTVSITPISADNTATTTTSSPSLDVKRTGGIEIIPLVGQGNNNSNSPINAGGSTTITITPINAGSTSTSPAHNNNKDKKPSNSPSYSSGSSGGAVVMNNMNSLVANINTSSTSTSSSTSSTSSSKRNMDGSAEGQKEKKRKKRRDDSPMGPPEKIFSRQNSPAGSSDASAGSRKFPSPSSSPKGSSGGLLASSVTGSSLSARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAAAASPKGDKSSNSSVSSVSASSVLNSAALVRSMANSNTSSSSCSALGTSSATANTNLVAAVKSAAAAAVKSSMGVNSAQMQQMKNVPGLSLMSAAAASNFSTGSTGSNSVSGLDLNSAMRKGVTTAVSLMTSTPAIAATTISKSPTLSVSLPGGLERPDKVKQPRPQVTVPMSHPGISEERASKMKSSNGNNEYMVKTSQEGLKMTINKTSSSAAKVSSSSTASLSSSYSSSSLNTNSKFSLKTSQRGGSPSLHVSSSSSTTSSGKKPHTGLKPGVSSGPASKKSTSSTGNSSRSSSKHSFQKSNSSGSLSTKSSSPSSGFGLSKSHSTNSFGDYPRKSFKKSHSASTSPALPTPYTSSSHSQPASLLDHQADMLKILHYASPTMAANMEGFMKGLNSKFQIPKLSQRNNASTTTTTTSATNSSTTASSTTADATHPAAAINDNNKKSNAITSSAQTQSSVSVHILKSPATNQTPSSSATSLLTSNSNKSTTLNFLHNTSTSPATKTLASNVTASSHIAADESPLMATSAAAVHSTSKTTPPLASK
Length1542
PositionMiddle
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.04
Grand average of hydropathy-0.444
Instability index52.43
Isoelectric point9.64
Molecular weight161932.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10800
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.76|      33|      36|    1273|    1308|       2
---------------------------------------------------------------------------
  963- 1003 (32.77/ 6.35)	KHNTAS..NSPKSPfGTHS.PKHGSSGkpSMSTlksaaAASPKG
 1279- 1315 (42.99/16.66)	KKSTSStgNSSRSS.SKHSfQKSNSSG..SLST....kSSSPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      24|      28|     812|     839|       3
---------------------------------------------------------------------------
  756-  783 (14.32/ 6.35)	ISADNtaTttTSSPSLDVKRT.........GGIEIIP
  786-  818 (29.60/ 7.67)	GQGNN..N..SNSPINAGGSTtititpinaGSTSTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.98|      22|      28|     911|     934|       4
---------------------------------------------------------------------------
  921-  948 (28.80/10.90)	RKFPSPSSSP...KGSSggllasSVTGSSLS
 1238- 1262 (26.18/ 6.95)	LKTSQRGGSPslhVSSS......SSTTSSGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.27|      27|      33|    1320|    1348|       5
---------------------------------------------------------------------------
  828-  860 (26.24/ 7.89)	PSNSPSYSsGSSGgavvmNNMN.S.LVANINTSST
 1023- 1051 (23.04/ 6.40)	AALVRSMA.NSNT.....SSSScSaLGTSSATANT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     175.38|      29|      33|    1320|    1348|       6
---------------------------------------------------------------------------
 1103- 1143 (27.46/ 7.63)	SNSVS.GLDLNSAMRKgvttavSLMTS...........TPAiaattiS.KSPTL
 1320- 1348 (49.76/21.05)	SKSHS.TNSFGDYPRK......SFKKS...........HSA......S.TSPAL
 1354- 1381 (33.04/10.99)	SSSHSqPASLLDHQAD......MLKIL...........HYA.........SPTM
 1462- 1501 (32.09/10.42)	LKSPA.TNQTPSSSAT......SLLTSnsnksttlnflHNT......S.TSPAT
 1510- 1539 (33.03/10.98)	ASSHI.AADESPLMAT......SAAAV...........HST......SkTTPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.58|      63|     259|     205|     275|       7
---------------------------------------------------------------------------
  205-  275 (100.66/85.51)	NIFQMQNFSKDAAQILQDSAVGIVMQRRGGHPMRLVYFVS.PYDLISVEsktlqpitLDTFNNKSIGFSVTV
  464-  527 (101.92/70.04)	NAISFQQISVALQHPYEESMATVEFDLRSGKPQCSIYSIShNYELLSIK........LTSIAQKCLSIPVTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.61|      29|     259|     879|     915|       8
---------------------------------------------------------------------------
  887-  915 (52.92/34.05)	KRKKRRD..DSPMGPP...EKIFSRQNSPAGSSD
 1156- 1189 (42.69/14.54)	KVKQPRPqvTVPMSHPgisEERASKMKSSNGNNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.59|      22|      24|     579|     601|       9
---------------------------------------------------------------------------
  579-  596 (29.25/12.59)	.........GNTHTSY....GNFNITGGGTN
  597-  620 (26.64/15.78)	DPgGGggggGMQRMSS....GSM...PGGVN
  624-  645 (22.71/ 8.16)	EP.NA....GNNQQQQrslvGP.NAVGG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.12|      11|      28|    1059|    1070|      10
---------------------------------------------------------------------------
 1059- 1070 (15.14/12.34)	SAAAAAvKSSMG
 1089- 1099 (19.98/11.27)	SAAAAS.NFSTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.54|      18|      33|    1401|    1420|      11
---------------------------------------------------------------------------
 1401- 1418 (26.82/12.31)	LSQRNNASTTTTTTSATN
 1421- 1438 (25.72/ 6.03)	TTASSTTADATHPAAAIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.60|      21|      38|     656|     693|      13
---------------------------------------------------------------------------
  656-  678 (28.20/17.59)	AAAGYMKyKNpAELKQEDFHESP
  696-  716 (35.41/35.11)	AASNLMQ.SN.LEINSLGHHQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.26|      15|      28|     303|     319|      16
---------------------------------------------------------------------------
  303-  319 (23.74/20.42)	MPA.FAPLTQMNsmLLPA
  329-  344 (24.52/13.56)	LPVcYNTLRAMG..LCPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.93|      17|      28|     101|     117|      17
---------------------------------------------------------------------------
  101-  117 (26.64/18.47)	LESLSRQLSLKFSDDSK
  132-  148 (28.29/20.18)	LDSNGSLTDVKVHHESK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10800 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AANMEGFMKGLNSKFQIPKLSQRNNASTTTTTTSATNSSTTASSTTADATHPAAAINDNNKKSNAITSSAQTQSSVSVHILKSPATNQTPSSSATSLLTSNSNKSTTLNFLHNTSTSPATKTLASNVTASSHIAADESPLMATSAAAVHSTSKTTPPLASK
2) HNMGGTATTGMGSSGPNISGGAGGAGSGGVGTGNL
3) LNTNSKFSLKTSQRGGSPSLHVSSSSSTTSSGKKPHTGLKPGVSSGPASKKSTSSTGNSSRSSSKHSFQKSNSSGSLSTKSSSPSSGFGLSKSHSTNSFGDYPRKSFKKSHSASTSPALPTPYTSSSHSQPASLLDHQADM
4) LSVSLPGGLERPDKVKQPRPQVTVPMSHPGISEERASKMKSSNGNNEYMVKTSQEGLKMTINKTSSSAAKVSSSSTASLSSSYS
5) MQSNLEINSLGHHQQTAQQQQQLEQQIAEHEIADK
6) SYGNFNITGGGTNDPGGGGGGGGMQRMSSGSMPGGVNIKLEPNAGNNQQQQRSLVGPNAVGGLLPQM
7) TVSITPISADNTATTTTSSPSLDVKRTGGIEIIPLVGQGNNNSNSPINAGGSTTITITPINAGSTSTSPAHNNNKDKKPSNSPSYSSGSSGGAVVMNNMNSLVANINTSSTSTSSSTSSTSSSKRNMDGSAEGQKEKKRKKRRDDSPMGPPEKIFSRQNSPAGSSDASAGSRKFPSPSSSPKGSSGGLLASSVTGSSLSARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAAAASPKGDKSSNSSVSSV
1382
544
1230
1143
701
584
750
1542
578
1370
1226
735
650
1014










Molecular Recognition Features






MoRF SequenceStartStop




NANANA