<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10796

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMNNYSNMMMGGEQFRKMDSNYSPKSSPHGGRSPVVSRQDSSGTLKATISLGKTPTIIQTGPFYSMKEPPGKGELTGDKDLMTEYGLHHTLTKFKDKKVKESLSSFLPNLPGIYDGMNNLENSTLRSVIDKPPIGGKELLPLTSVQLAGFRLHPGPLPEQYRAFNTIPARKHKNKHKKHKHKDGQQPPETNLMDSSGLETYEKKHKKQKRHEDEKERKKRKKEKKRKKKSHSPEPPSSGGVSPMLGGGSQIPGVGGMMMGGPSSMSAMQGGAVGMGSSLQGLATGPNNPLGPGSGVTNMSGPGGMMMPQHASLF
Length314
PositionHead
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.04
Grand average of hydropathy-0.895
Instability index54.67
Isoelectric point9.94
Molecular weight34003.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10796
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.92|      26|      45|     239|     265|       1
---------------------------------------------------------------------------
  239-  265 (48.53/20.86)	GGVSPmLGGGS...QIPGVGGMMMGGPSSM
  285-  313 (48.38/17.33)	GPNNP.LGPGSgvtNMSGPGGMMMPQHASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.92|      17|      18|       4|      20|       2
---------------------------------------------------------------------------
    1-   17 (33.21/17.03)	MMNNYS..NMMMGGEQ..FRK
   18-   38 (22.71/ 9.56)	MDSNYSpkSSPHGGRSpvVSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.57|      13|      18|     202|     214|       3
---------------------------------------------------------------------------
  173-  184 (23.19/12.27)	KNKHKKHK.HKDG
  202-  214 (25.31/13.98)	EKKHKKQKRHEDE
  223-  234 (22.07/11.36)	EKKRKK.KSHSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.71|      10|      21|     103|     112|       4
---------------------------------------------------------------------------
   87-   96 (15.21/ 6.88)	LHHTLTKFKD
  103-  112 (17.50/ 8.94)	LSSFLPNLPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10796 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEQFRKMDSNYSPKSSPHGGRSPVVSRQDSSGTLKATISL
2) LPGIYDGMNNLENSTLRSVIDKPPIGGKELLPLTSVQLAGFRLHPGPLPEQYRAFNTIPARKHKNKHKKHKHKDGQQPPETNLMDSSGLETYEKKHKKQKRHEDEKERKKRKKEKKRKKKSHSPEPPSSGGVSPMLGGGSQIPGVGGMMMGGPSSMSAMQGGAVGMGSSLQGLATGPNNPLGPGSGVTNMSGPGGMMMPQHASLF
12
110
51
314










Molecular Recognition Features






MoRF SequenceStartStop




1) ARKHKNKHKK
2) KKRKKKSH
3) YRAFNTI
169
224
161
178
231
167