<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10784

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQSHQTNGASLEDCHTNFFALTDLCGIKWRKFVNSERPNASSDPLDDPILRSYSRCMQADILCVWRRVQSTRQDNSDPNAIFEVVNTSKVHPPLSLAAAKELWLFWYGEEPDLTDLVDAELLKVAGNQMLWNGTWERGLTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSNERIFCRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFNAAASNANSPEQTSPNSPNGATEVGAKENAGSNSPAVANNAAGGNSSSGSGNNSTTSNNANGSGGTPKPRKVILAPFGMAATLTGNSYKHNDPMAEKILEDWASFFPLCNKENSEVPPVVEVIAGGHKMYHPSIYVLVTDLDDMEEMEAAASQKSSLGSTSSAEAAAAIAALSSSANSHTNDTRKPLTESVTNNNKLASSAANAMTTSSSSPTSNAATTKSSLAHMIERLKIDHTKVQQYYDTQTQNFTCNTTNTHAPPQAACEMPERVWQDCVTNTLHLQNGTICNTATSSSGTTTSASTSNPNNNTSSVSPSLNTMMGSGNDNNSTTIPMNTDAGDQTDNASNMMDIKPNLNTTTTALSQSQQQQIWGFVDPTQKSTCICTKSSQTSTSLSGQTPGNGTPLQGGISSYSRNSIMDCMQIPSVGSPGTPAPSPHPNSALSQPTSVPPADQLLMSPRAPTSVPNLQQPTTPIDHLLDKNTPAPTPTDQHDNKSITASPYIHPTPSVEAPPSVEGMHCGNLGGGNGGMGPASVGAQPPSVGRCTPTLHQQQQQHQSSQPTQAQQQCGSISVKKFDVQPGTPLLLGSGGNNNSSNPVAGGVVPTDDKPDSVKTMPNSRTALPNNNFSRNNTAPSATNAMHDFYNLCKPPKISVKDIDAIANEDCLKLENLYDFPTQDIWANHPAKRFKPNEISKHNRVPRTKALYERHTHIKPLLLSPRSLYGDQLLAIDPTAAAAAGTGSSGMEGSGGAGNCGMVGTGLVGIAPNPMANNKINNNENSGGGMMNSTTTASGGSIFEELDIKTEVPPAVGASSISPSKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECGSVQIHTPPDSNNPSNGCAVTTNTIDELKRSTNSGLVGAVNVQGNSAAVMAALQNCNSVVNATTSGMASLNNSGGSLTGGGPGGLGVGPNTIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIQMTDLNVMTSTNIMGGQTLDTGLGISAMTKVKQEYSSELGSPIEGPIEDWTYVYRPPAQAIFVGSSKYAPLTNLPSQSMAPLSMPSNCRYKPSWQQPRSAHQQQQQQQQQQQHMQQQQQQQLQQQQQHQQLHELLSAAPRTPLQQQPRTPLGPMSSSPMHNTTVPTPLSSGGGGSSSLLLNQLNCPQAALTNNPLTMQHIMQRPGMSPISPATHVPFPHTSPMMQQHRQTPIHPPPPYEVAVASPALSTASSTPAYLNKQYHSQEPPQTPQSVPNHIQTIGGPPSVQGNNRESSNMGFYAPANNINSIIQELPEVSSVIVNILLYDTALNVFRDHNFDSSTVCVCNADNQRIGNIRGSDSGVYVPLPGTSFNPTAPSLSTANAMRALSAFGGGGSSMGVALGSTAGGGSILGSVSAAGIANSLDSPASLAGAGSSSSTTPSTATPANNAQQYITGYVDDDAVECTCGFSAVINRRLACKAGLFYEDEMEITGIAEDPGRHKKHSLLTLLINLSSKANNNSSNNNNTNSNGIVDKTAEQVAYSLFDLLLEQCSIIQTSSSAIHRALQRHRRRLSKRSQKPQSVAGIVNVLEYIDANDIIALALEQARLAYDSSNRMDIMEQQMIPFSSHRKTSNNTQVALALTGRINVHKWPYIPVGFSRSNKDIVSTMKSIQPMLQNAFHVKSRTAGSRDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPPAIHYWDKFLLEPYSYARDVVYLVMAPDNDYVLSKTKSYFKELSTIYEMCKLGRHTPICGWNGLLAVQQRPANDKAFSTNMDNWLKSLDDARLAEQLRLYAHAFQHQLAPYLNRVPGDKTLLNPPETSARCSQGYSTATSSSTNSSSSSSSSFMMGGVNNSNTTGGMDNTGQGAGAADHSQPMDTNEHSQHATGTNSSSDSQGNSSGDAKPTDLKPDVKPPLVLGDPLGVADCLEEVNPSAIVLYVVEPFTFGSDSPELERLACIALLRMYSELLKMIPDSVKAHINIQIISLESILELGRSRSRKRTSDEIKCLALNIFSQCKRHMVHAQSVKSLTGFGTAANVEAFLKTKDEKNRRPYKMYTPPYILAPMHEKNEKTDFSRAAWGGMRGSPNEQKYSVMYCNYCLSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTKRRRAPARRIGLNKLMDFILGLISQTTQTWRLVVGRIGRIGHNELKSWSYLLGKQNLQKATKQLRDMCKQCQLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFPNEPQVDLDEDFINFGNDEDENDVFKDADLMDDLLGQWDGGGTARGMSNHNSPDRMEDNRSWQSVGGNNFNTNQHQDIEEVGSINQQPLAVGYMVSTAPTGRMPAWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIT
Length2724
PositionMiddle
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.06
Grand average of hydropathy-0.467
Instability index49.50
Isoelectric point6.01
Molecular weight293851.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10784
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.89|      15|      15|    1305|    1319|       1
---------------------------------------------------------------------------
 1305- 1319 (31.09/15.04)	QQQQ.QQQQQQQHMQQ
 1321- 1336 (26.80/12.00)	QQQQlQQQQQHQQLHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.50|      21|      21|    1394|    1414|       4
---------------------------------------------------------------------------
 1394- 1414 (40.95/21.90)	TNNPLT.MQHIMQRPGMSPISP
 1416- 1437 (38.55/20.14)	THVPFPhTSPMMQQHRQTPIHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.02|      18|      21|    1595|    1615|       5
---------------------------------------------------------------------------
  967-  984 (31.34/ 9.22)	GTGSS.GMEGSGGAGNCGM
 1595- 1613 (29.68/12.37)	GGGSSmGVALGSTAGGGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.98|      14|      21|     262|     275|       6
---------------------------------------------------------------------------
  262-  275 (26.49/14.41)	GS.NSPAVANNA..AGG
  280-  296 (17.50/ 6.46)	GSgNNSTTSNNAngSGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.23|      15|      21|     664|     684|       7
---------------------------------------------------------------------------
  678-  693 (24.14/ 7.17)	PPADQLL...mSPR......APTSV
  775-  799 (12.09/ 9.59)	PTLHQQQqqhqSSQptqaqqQCGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.11|      18|      22|     616|     633|       8
---------------------------------------------------------------------------
  514-  531 (27.04/12.09)	GTICNTATS..........SSGTTTSAS
  597-  624 (23.16/ 8.90)	QQIWGFVDPtqkstcictkSSQTSTSLS
  625-  647 (24.91/10.34)	GQTPGNGTP.....lqggiSSYSRNSIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.33|      43|     114|    1338|    1380|       9
---------------------------------------------------------------------------
  694-  716 (28.51/ 7.36)	...............PNLQQPTTPIDHLLD...KNTPAPTP..........
  807-  823 (26.35/ 6.26)	...................QPGTPL...............LLGSGGNNNSS
 1338- 1380 (83.12/35.14)	LSAAP........RTPLQQQPRTPLGPMSSSPMHNTTVPTPLSSGGGGSSS
 1450- 1496 (63.36/25.09)	LSTASstpaylnkQYHSQEPPQTP....QSVPNHIQTIGGPPSVQGNNRES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.74|      20|      23|     404|     423|      10
---------------------------------------------------------------------------
  404-  423 (33.97/19.25)	SSSANSHTNDTRKPLTESVT
  430-  449 (32.76/18.24)	SSAANAMTTSSSSPTSNAAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.33|      22|      23|     897|     918|      11
---------------------------------------------------------------------------
  873-  896 (24.92/11.95)	.NLCK...PPkisVKDIDAIANEDCLKL
  897-  918 (41.03/24.98)	ENLYD...FP...TQDIWANHPAKRFKP
  919-  942 (21.38/ 9.08)	NEISKhnrVP..rTKALYERH..THIKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     342.03|      77|     114|    1039|    1118|      12
---------------------------------------------------------------------------
  458-  508 (33.50/ 9.35)	.....................IERLKI........DHTKVqqyYDTqTQNF.TCNTTNTHAPPQAacEMPErvwQDC..VTNT............
 1039- 1118 (123.77/64.81)	GASSISPSKDSKSGIGGNlfTVEGLNPSPN.....DLEQL...FET.SSND.ECGSVQIHTPPDS..NNPS...NGCAVTTNTIDeLKRSTNSGL
 1148- 1216 (108.88/49.35)	GMASLNNSGGSLTG.GGP....GGLGVGPNtiqaeDLTKM...FPT.PPSH.E....QHH..PNS...SP......CQMDIQMTD.LNVMTSTNI
 1227- 1283 (75.87/31.90)	GISAMTKVKQEYSSELGS..PIEG..P.IE.....DWTYV...YRP.PAQAiFVGSSKY..APLT..NLPS...QSMA.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.26|      13|      24|     733|     748|      13
---------------------------------------------------------------------------
  733-  748 (16.00/22.89)	PTpSVEA.PPSVeGmHC
  760-  773 (24.26/12.46)	PA.SVGAqPPSV.G.RC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.62|      13|    1315|     828|     841|      14
---------------------------------------------------------------------------
  828-  841 (21.82/16.48)	GGVVPTDDKPDsVK
 2146- 2158 (25.80/14.65)	GDAKPTDLKPD.VK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.01|      26|     143|     213|     240|      15
---------------------------------------------------------------------------
  213-  240 (39.71/31.04)	HPAVRPLTKEhlAEAAAAFNAAASNANS
  362-  387 (42.30/26.07)	HPSIYVLVTD..LDDMEEMEAAASQKSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      19|      20|    1615|    1633|      16
---------------------------------------------------------------------------
 1615- 1633 (30.48/17.67)	GSVSAAGIANSLDSPASLA
 1634- 1652 (32.44/19.45)	GAGSSSSTTPSTATPANNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.97|      35|      35|    1679|    1713|      17
---------------------------------------------------------------------------
 1656- 1675 (24.05/10.06)	................ITGYVDDDAVECTCG.FSAVI
 1679- 1713 (57.66/35.20)	LACKA..GLFYEDEMEITGIAEDPGRHKKHSLLTLLI
 1715- 1751 (49.26/28.91)	LSSKAnnNSSNNNNTNSNGIVDKTAEQVAYSLFDLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.28|      17|     716|     850|     868|      18
---------------------------------------------------------------------------
  850-  868 (29.62/21.59)	LPNNNFsrNNTAP..SATNAM
 1569- 1587 (29.66/14.93)	LPGTSF..NPTAPslSTANAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.85|      26|    1077|    1004|    1029|      19
---------------------------------------------------------------------------
  563-  579 (21.09/ 7.01)	.........MNTDAGDQTDNASNMMD
 1004- 1029 (45.09/25.12)	NNENSGGGMMNSTTTASGGSIFEELD
 2098- 2123 (47.66/27.06)	NNSNTTGGMDNTGQGAGAADHSQPMD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10784 with Med13 domain of Kingdom Metazoa
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