<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10778

Description Uncharacterized protein
SequenceMLLLQEKRPLKRALGPPDVYPQDARQREDELTPSNVKHGFATMPPLSDEFGTAHTSNVNASKVASFFNAIVAKKEELMTLQDTVRKKQQFNIKDNFWPVSPRTKTALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWYIKLSAAYTASVSESKNKKRNLIDPVTEWTGILIKFMKDLLPKLQEYYHLSEKSTPAERALMSGYGAPTTNSNGNGQNVHAPNSLTAAHSMASPVPMLSPANSQSSTGASMGSMSNNSSSMVGCSSNQNVLSGGSNMPATGSTISGSGSNFEDSRNALKYWNYCAQLAKYMHEEQLLDRQEFLNWILELLDKMRTQSTFDESLKKLILTFALQYMHDFVQSERLCRKMAYIVAKKLSNLLNGVIDQQQLNSNHQQPKPLQALQGVTPMDVDDIDEGCQKKKTPLDPYEVALNEYLTCPHHRDIVLCLSSILQIVTIECPTAMVWCGIGENRAPASLCGSPLDHLPLAPSSLPMPSKCPLTNNEVRRQLRSIESEIILRSKHAENRWFAEKWLNAXKNNLKYFKYRDNINAYFSRPNPRVMLLLQEKRPLKRALGPPDVYPQDARQREDELTPSNVKHGFATMPPLSDEFGTAHTSNVNASKVASFFNAIVAKKEELMTLQDTVRKKQQFNIKDNFWPVSPRTKTALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWYIKLSAAYTASVSESKNKKRNLIDPVTEWTGILIKFMKDLLPKLQEYYHLSEKSTPAERALMSGYGAPTTNSNGNGQNVHAPNSLTAAHSMASPVPMLSPANSQSSTGASMGSMSNNSSSMVGCSSNQNVLSGGSNMPATGSTISGSGSNFEDSRNALKYWNYCAQLAKYMHEEQLLDRQEFLNWILELLDKMRTQSTFDESLKKLILTFALQYMHDFVQSERLCRKMAYIVAKKLSNLLNGVIDQQQLNSNHQQPKPLQALQGVTPMDVDDIDEGCQKKKTPLDPYEVALNEYLTCPHHRDIVLCLSSILQIVTIECPTAMVWCGIGENRAPASLCGSPLDHLPLAPSSLPMPSKCPLTNNEVRRQLRSIESEIILRSKHAENRWFAEKWLNANKNSYTHVLTILDHLDTHCFDLMDQSNSIDTLYANIFQPFVSVRREVGANGEVNEIHQEYDANIVDGNTVKILCEWAVSSQRWGEHRAIVVAILLDKRQIEVTTPSAEDVNNGNGNGNNPNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGSTANRTQFTNLVHLFSALIRHDVFSHNAYMYTLISRGDLLEGANGMGNSNLNNKPSNIVANSVSGPVSNKPVTPPPNNQGFDDDFTSGLDFKHNEYDDSNVDDDLEKILQNIKEKGQVQAPDSPKIPEHSNSNGGNTISRHYIYTKHFPIPQDDSSMSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEICKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTSKCQNMAYFDQHVVTSQCAATVLEQLNGFAVGSNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPEVENQLQVKKSNMVRSYTTSLGLYIVGILRRYHSCLLLSPEQTISVFEGLCRIIKHVTNPAECSSAERCILAYLNDLYEACHLLRSKDQEAEFFLQISNIKKFKDIINQPEQLGMVPQNYNAQFMQEFFASPKRGGKIDPLWLRQLHESPANIYSFVSNVIFAVCHETDNDRLNDIAIACAELTAGCNALSEEWIAALQSICNAMKKTRYPHLCQIDIQNSKIHNSLAVFICILVARHCFTLAEFLMNFALPTLANAYPVPGCGEITADAESGARLTCHLVLKLFKTIEIPQPGMYSVSTSPNPLNAVNSSSNIKLSCDRHLLIAAHKNLPLEAVLAVLKAILIVVDTTPSMAGNSSTGAFGSGGGTSGKRGSGFNTPVHPGSTPKSNDRPVDISQILGTSDLNSHTGDHDHDMSQPLSTTPLNANQGPNGEQISLLEFAQHVLKQICAQEHVLGRCLKNADKLCDMVVDDMLTPKQSQSILHMIFYSEAEYNIISELDQRSMIVRILENLGQWTLRISWLDLQLMHKQSMNNPSELMTWLDTVARAAIDVFLMEEVVTGSGGKTEYRPKPSTWLVAPLVSKLTPAVQGRILRVAGQVLESMNYFSKSSKADNNSSCSGDEREKSNSCGSASSSYSNGSNGSSRNKKMPLNYQPFLGLILTCLKGQDEYKESLLVSLHSQLSQCLQSYAEFDTMGGVDDPQGREEMLDALQLRFSLVGGMFDSIQKNSTSITDWAILLVQLVCQGVIDLSTNRELFTTVVDMLTTLVHSTLVSDGQSERDERLYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKQPTEVISCEPAALDQKGNKINDMDKRLMRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEESHRNLKYHTHSLAKPSSYYYEALPLPPEEVEPVPVVPVTPTPPFLQKDEMKADTPSSVDQSPSAVVTGRGRGKGTTRKRKPKQPKNAPATNVQPTPQITGTQVGQGPQQVPGQQQQVIPQQQQQQQQQQQQQQQQQQQQQQMAQQQQQQQQQQQQQQVPQQAMNAQQQMGQIPMNMQMGGNVNMQQFNPNQMMQQNPNAMMQQQQMQGVPGNMAQQMNVGNPQQNQQMNFMGPGGPQSMQQAGMNPQAQQWQGPNQFHPMQQQQPQQQYQYPQQQQQLNRFERPQINNPKHALQNMLRQRQPTFNQNNQNFSAMQQQQRQGMPTQQQPGGLNPVQQQQMQQQQFGRAGMRGMAPNQMAGVAPNQIAPGMGNQVAMSAQGMGGQNPMMQQQMSAQGMNPQANTQMGMNQNAGMMGATATGNPNMMTAQANSGMVNTGGMMQQNVGVGVGVGNSNVVNQGMVNQGGPGQFQNFNQYQQQGMNQTPGPNQQANMMGGFNQMNQRTNPADFMAQQQRGTGAMAGQRGQYMNQAPNVTMSNMMGQGNVPPYQRQQSTGGKPGVTQQQFQQQQRMQQMMQMQGMGPQNAGAGGMGQPQNQNVAQQQNPNLVAQLQRQMPNQPNMMGGPQYQQHPPPY
Length3085
PositionKinase
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.06
Grand average of hydropathy-0.541
Instability index50.68
Isoelectric point7.78
Molecular weight343276.54
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10778
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    2393.19|     546|     569|       1|     546|       1
---------------------------------------------------------------------------
    1-  546 (1196.59/807.26)	MLLLQEKRPLKRALGPPDVYPQDARQREDELTPSNVKHGFATMPPLSDEFGTAHTSNVNASKVASFFNAIVAKKEELMTLQDTVRKKQQFNIKDNFWPVSPRTKTALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWYIKLSAAYTASVSESKNKKRNLIDPVTEWTGILIKFMKDLLPKLQEYYHLSEKSTPAERALMSGYGAPTTNSNGNGQNVHAPNSLTAAHSMASPVPMLSPANSQSSTGASMGSMSNNSSSMVGCSSNQNVLSGGSNMPATGSTISGSGSNFEDSRNALKYWNYCAQLAKYMHEEQLLDRQEFLNWILELLDKMRTQSTFDESLKKLILTFALQYMHDFVQSERLCRKMAYIVAKKLSNLLNGVIDQQQLNSNHQQPKPLQALQGVTPMDVDDIDEGCQKKKTPLDPYEVALNEYLTCPHHRDIVLCLSSILQIVTIECPTAMVWCGIGENRAPASLCGSPLDHLPLAPSSLPMPSKCPLTNNEVRRQLRSIESEIILRSKHAENRWFAEKWLNA
  572- 1117 (1196.59/807.26)	MLLLQEKRPLKRALGPPDVYPQDARQREDELTPSNVKHGFATMPPLSDEFGTAHTSNVNASKVASFFNAIVAKKEELMTLQDTVRKKQQFNIKDNFWPVSPRTKTALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWYIKLSAAYTASVSESKNKKRNLIDPVTEWTGILIKFMKDLLPKLQEYYHLSEKSTPAERALMSGYGAPTTNSNGNGQNVHAPNSLTAAHSMASPVPMLSPANSQSSTGASMGSMSNNSSSMVGCSSNQNVLSGGSNMPATGSTISGSGSNFEDSRNALKYWNYCAQLAKYMHEEQLLDRQEFLNWILELLDKMRTQSTFDESLKKLILTFALQYMHDFVQSERLCRKMAYIVAKKLSNLLNGVIDQQQLNSNHQQPKPLQALQGVTPMDVDDIDEGCQKKKTPLDPYEVALNEYLTCPHHRDIVLCLSSILQIVTIECPTAMVWCGIGENRAPASLCGSPLDHLPLAPSSLPMPSKCPLTNNEVRRQLRSIESEIILRSKHAENRWFAEKWLNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     332.41|      20|      20|    2574|    2593|       2
---------------------------------------------------------------------------
 2557- 2579 (27.75/ 7.16)	VGQGP.........QQVP....GQQ.....QQvipQQQQQQ
 2580- 2600 (34.56/10.83)	QQQQQ.........QQQQ....QQQ.....QQ..qQMAQQQ
 2601- 2620 (35.12/11.13)	QQQQQ.........QQQQ....QQV.....PQ...QAMNAQ
 2621- 2649 (27.03/ 6.77)	QQMGQipmnmqmggNVNM....QQF.....NP...NQMMQQ
 2686- 2705 (31.86/ 9.37)	GPGGP.........QSMQ....QAG.....MN...PQAQQW
 2706- 2725 (32.84/ 9.91)	QGPNQ.........FHPM....QQQ.....QP...QQQYQY
 2773- 2796 (28.52/ 7.57)	RQGMP.........TQQQpgglNPV.....QQ...QQMQQQ
 2833- 2857 (27.91/ 7.24)	GMGGQ.........NPMM....QQQmsaqgMN...PQANTQ
 2917- 2936 (32.86/ 9.92)	GGPGQ.........FQNF....NQY.....QQ...QGMNQT
 3020- 3039 (25.93/ 6.17)	QQRMQ.........QMMQ....MQG.....MG...PQNAGA
 3064- 3081 (28.02/ 7.30)	RQMPN.........QPNM....M.G.....G....PQYQQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     213.61|      30|     192|    2743|    2772|       3
---------------------------------------------------------------------------
 2660- 2730 (34.39/12.64)	MQG.VPG....NMAQQMN.......................VGNPQ.QN....QqmNF..MgpggpqsmqqagmnpqaqqwqgpnqfhpmqqqqpqqqyqypQQQQ
 2743- 2772 (51.17/23.26)	PKH.ALQ....NMLRQRQ.......................PTFNQ.NN....Q..NFSAM.........................................QQQQ
 2811- 2832 (27.47/ 8.25)	MAGvAPN........QIA.......................PGM...GN....Q..V.AMS.........................................AQ..
 2871- 2897 (42.50/17.77)	ATG.NPN....MMTAQAN.......................SGMV...N....T..G.GMM.........................................QQNV
 2980- 3005 (32.67/11.55)	MNQ.APNvtmsNMMGQGN.......................VP.PY.Q......................................................RQQS
 3006- 3063 (25.42/ 6.96)	TGG.KPG....VTQQQFQqqqrmqqmmqmqgmgpqnagaggMGQPQnQNvaqqQ..NPNLV.........................................AQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.75|      17|     192|    1174|    1190|       4
---------------------------------------------------------------------------
 1174- 1190 (31.24/21.39)	HQEYDANIVDGNTVKIL
 1369- 1385 (31.51/21.65)	HNEYDDSNVDDDLEKIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.08|      41|     159|    2190|    2232|       5
---------------------------------------------------------------------------
 2190- 2232 (67.89/49.55)	DEREKSNSCGSASSSYSNGSNGSSRNKK..MPLNYQPflGLILTC
 2350- 2392 (64.19/40.17)	DERLYSNLMKKLKKEIGEKNNASIKVIRqlLPLYKQP..TEVISC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.69|      16|      17|    1963|    1978|       6
---------------------------------------------------------------------------
 1963- 1978 (29.18/17.05)	DISQILGTSDLNSHTG
 1983- 1998 (30.51/18.23)	DMSQPLSTTPLNANQG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10778 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDLEKILQNIKEKGQVQAPDSPKIPEHSNSNGGNTI
2) EVEPVPVVPVTPTPPFLQKDEMKADTPSSVDQSPSAVVTGRGRGKGTTRKRKPKQPKNAPATNVQPTPQITGTQVGQGPQQVPGQQQQVIPQQQQQQQQQQQQQQQQQQQQQQMAQQQQQQQQQQQQQQVPQQAMNAQQQMGQIPMNMQMGGNVNMQQFNPNQMMQQNPNAMMQQQQMQGVPGNMAQQMNVGNPQQNQQMNFMGPGGPQSMQQAGMNPQAQQWQGPNQFHPMQQQQPQQQYQYPQQQQQLNRFERPQINNPKHALQNMLRQRQPTFNQNNQNFSAMQQQQRQGMPTQQQPGGLNPVQQQQMQQQQFGRAGMRGMAPNQMAGVAPNQIAPGMGNQVAMSAQGMGGQNPMMQQQMSAQGMNPQANTQMGMNQNAGMMGATATGNPNMMTAQANSGMVNTGG
3) GANGMGNSNLNNKPSNIVANSVSGPVSNKPVTPPPNNQGFDDDFTSGL
4) GNSSTGAFGSGGGTSGKRGSGFNTPVHPGSTPKSNDRPVDISQILGTSDLNSHTGDHDHDMSQPLSTTPLNANQ
5) HSMASPVPMLSPANSQSSTGASMGSMSNNS
6) HSMASPVPMLSPANSQSSTGASMGSMSNNS
7) KADNNSSCSGDEREKSNSCGSASSSYSNGSNGSS
8) VVNQGMVNQGGPGQFQNFNQYQQQGMNQTPGPNQQANMMGGFNQMNQRTNPADFMAQQQRGTGAMAGQRGQYMNQAPNVTMSNMMGQGNVPPYQRQQSTGGKPGVTQQQFQQQQRMQQMMQMQGMGPQNAGAGGMGQPQNQNVAQQQNPNLVAQLQRQMPNQPNMMGGPQYQQHPPPY
1378
2483
1318
1924
241
812
2180
2908
1414
2891
1365
1997
270
841
2213
3085










Molecular Recognition Features






MoRF SequenceStartStop




1) NMPTQ
90
94