<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10772

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDWQSPKFRQNVINKIEMMQITTQEGKNASFMENHIFSKSKSQDEYLGLVAKLFMHLKELANRRPQQAPPPNVEVSQQNMMQDPLNALQNLASQGNRNPQMMSMPGGGPNAQQGGQGPSGPVPASNLLQTLNQQRPGQQMQQMPGLRPQMAMGGAVGPGQQQGNMGPGQQQMMGGPMAVQMNMMGGPGVGPNQQMVGNAQMGGPSGGPVGVGIGPGGPQGMTGQMNQMAGPGTVGPMGPNAGPGGPNQMQMGVQHPQLNQMMNARMNQGGPNGPMNVGGHAGPNQGMPPNMQTNQVGIGGTAGGPMHMVNMGPGNANQGQGPGPMANNAGPQGNLNQMLNMPPGMQKNPNITMGQGQQMFNVNRGVGGQQQFLRQSPSPSTVSSPANSLNVQQQQQQQMQQQVANNQQQMQQQPNQNIVPQNTIPNQQMIPSPALVPIASPQMSGLMQNPNQRQQMRQSPSAPVNTPGQVTQNSPFNPQEDQLYREKYKQLTKYIEPLRRVVDKLRIGGNNNAENYKKMNKLLEILTNPSQRVPLETLLKCEKVLENTDINSYSDHSFGKSSNPLMDVINTTLQSPLANHTLYRTFRPSLELLFGTDIAAPPAKMPRPAEKPSKGDLEIPHVLQGEIARLDQKFKVSLDPAAQNNPKSIRLICCLDDKKLPCVPPVSINIPEDYPWSSPECSLIEHDYSATPFLKAVQNALVARIAKLPKLHSLSHLLDTWEMSVRQACSPNAAKPVCEFTALFGM
Length748
PositionTail
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.03
Grand average of hydropathy-0.664
Instability index55.98
Isoelectric point9.29
Molecular weight80791.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10772
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.14|      21|      22|     172|     193|       1
---------------------------------------------------------------------------
   99-  119 (30.21/ 6.18)	RNP...QMMsmpgGGP..NA.Q...QGGQG
  167-  190 (44.29/14.33)	MGPgqqQMM....GGP..MAVQMNMMGGPG
  215-  234 (33.63/ 7.85)	IGP..........GGPqgMTGQMNQMAGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     313.37|      45|      45|     241|     285|       2
---------------------------------------------------------------------------
  156-  214 (39.24/ 6.83)	GAVGP......gQQ.........QGN.mgpgqqqmmggpmavqmnmmggpgvGPNQ..QM.VG.............NAQMG.G.PSGGPVGVG
  237-  280 (87.18/25.41)	GPMGP.................nAGPG.........................GPNQM.QMGVQHPQLNQMM.....NARMNQG.GPNGPMNVG
  281-  328 (39.93/ 7.10)	GHAGP..nqgmpPNmqtnqvgigGTAG.........................GPMHMvNMG...PG..........NA..NQGqGP.GPM..A
  329-  369 (42.86/ 8.24)	NNAGPqgnlnqmLN.........MPPG......................mqkNPN.I.TMG....QGQQMF.....N..VNRG........VG
  370-  422 (51.79/11.70)	GQQQF...lrqsPS.........PSTV.........................SSPAN.SLNVQQQQQQQMQqqvanNQQQMQQ.QPNQNI.VP
  423-  469 (52.38/11.93)	QNTIPnqqmipsPA.........LVPI.........................ASPQM.SGLMQNPNQRQQM.......R...Q.SPSAPVNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.82|      36|      45|     509|     552|       3
---------------------------------------------------------------------------
  516-  552 (57.90/47.30)	ENY......KKMNKLLEILtNPSQRVPL..ETLLKCEK....VLENTDI
  553-  600 (43.93/19.13)	NSYsdhsfgKSSNPLMDVI.NTTLQSPLanHTLYRTFRpsleLLFGTDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.28|      21|      24|     629|     649|       5
---------------------------------------------------------------------------
  629-  649 (35.81/22.34)	IARLDQKFKVSLDPAAQNNPK
  654-  674 (40.47/26.29)	ICCLDDKKLPCVPPVSINIPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10772 with Med15 domain of Kingdom Metazoa
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