<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10771

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMMQITTQEGKNASFMENHIFSKSKSQDEYLGLVAKLFMHLKELANRRPQQAPPPNVEVSQQNMMQDPLNALQNLASQGNRNPQMMSMPGGGPNAQQGGQGPSGPVPASNLLQTLNQQRPGQQMQQMPGLRPQMAMGGAVGPGQQQGNMGPGQQQMMGGPMAVQMNMMGGPGVGPNQQMVGNAQMGGPSGGPVGVGIGPGGPQGMTGQMNQMAGPGTVGPMGPNAGPGGPNQMQMGVQHPQLNQMMNARMNQGGPNGPMNVGGHAGPNQGMPPNMQTNQVGIGGTAGGPMHMVNMGPGNANQGQGPGPMANNAGPQGNLNQMLNMPPGMQKNPNITMGQGQQMFNVNRGVGGQQQFLRQSPSPSTVSSPANSLNVQQQQQQQMQQQVANNQQQMQQQPNQNIVPQNTIPNQQMIPSPALVPIASPQMSGLMQNPNQRQQMRQSPSAPVNTPGQVTQNSPFNPQEDQLYREKYKQLTKYIEPLRRVVDKLRIGGNNNAENYKKMNKLLEILTNPSQRVPLETLLKCEKVLENTDINSYSDHSFGKSSNPLMDVINTTLQSPLANHTLYRTFRPSLELLFGTDIAAPPAKMPRPAEKPSKGDLEIPHVLQGEIARLDQKFKVSLDPAAQNNPKSIRLICCLDDKKLPCVPPVSINIPEDYPWSSPECSLIEHDYSATPFLKAVQNALVARIAKLPKLHSLSHLLDTWEMSVRQACSPNAAKPVCEFTALFGM
Length729
PositionTail
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.03
Grand average of hydropathy-0.653
Instability index54.46
Isoelectric point9.31
Molecular weight78475.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10771
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.84|      18|      22|     153|     174|       1
---------------------------------------------------------------------------
  148-  171 (35.21/12.69)	MGPgqqqmmGGP..MAVQMNMMGGPG
  196-  215 (33.63/ 6.82)	IGP......GGPqgMTGQMNQMAGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     310.08|      45|      45|     222|     266|       2
---------------------------------------------------------------------------
  137-  195 (38.76/ 6.64)	GAVGP......gQQ.........QGN.mgpgqqqmmggpmavqmnmmggpgvGPNQ..QM.VG.............NAQMG.G.PSGGPVGVG
  218-  261 (88.03/25.80)	GPMGP.................nAGPG.........................GPNQM.QMGVQHPQLNQMM.....NARMNQG.GPNGPMNVG
  262-  309 (39.67/ 6.99)	GHAGP..nqgmpPNmqtnqvgigGTAG.........................GPMHMvNMG...PG..........NA..NQGqGP.GPM..A
  310-  350 (42.79/ 8.20)	NNAGPqgnlnqmLN.........MPPG......................mqkNPN.I.TMG....QGQQMF.....N..VNRG........VG
  351-  403 (50.77/11.31)	GQQQF...lrqsPS.........PSTV.........................SSPAN.SLNVQQQQQQQMQqqvanNQQQMQQ.QPNQNI.VP
  404-  450 (50.05/11.03)	QNTIPnqqmipsPA.........LVPI.........................ASPQM.SGLMQNPNQRQQM.......R...Q.SPSAPVNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.93|      32|      46|      49|      87|       3
---------------------------------------------------------------------------
   51-   85 (53.09/19.59)	APPPNVEVSQQNMM.....QDPLNALQNLAsqGNRnPQM.M
   98-  135 (51.84/13.60)	GQGPSGPVPASNLLqtlnqQRPGQQMQQMP..GLR.PQMaM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.93|      21|      22|     530|     550|       4
---------------------------------------------------------------------------
  471-  498 (20.41/10.06)	Y..KQLTKYIEPLRRvvdklriggNNNAEN
  536-  558 (30.11/18.48)	YSDHSFGKSSNPLMD.......viNTTLQS
  560-  581 (18.41/ 8.32)	LANHTLYRTFRPSLE......llfGTDI..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.28|      21|      24|     610|     630|       6
---------------------------------------------------------------------------
  610-  630 (35.81/17.93)	IARLDQKFKVSLDPAAQNNPK
  635-  655 (40.47/21.12)	ICCLDDKKLPCVPPVSINIPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10771 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKELANRRPQQAPPPNVEVSQQNMMQDPLNALQNLASQGNRNPQMMSMPGGGPNAQQGGQGPSGPVPASNLLQTLNQQRPGQQMQQMPGLRPQMAMGGAVGPGQQQGNMGPGQQQMMGGPMAVQMNMMGGPGVGPNQQMVGNAQMGGPSGGPVGVGIGPGGPQGMTGQMNQMAGPGTVGPMGPNAGPGGPNQMQMGVQHPQLNQMMNARMNQGGPNGPMNVGGHAGPNQGMPPNMQTNQVGIGGTAGGPMHMVNMGPGNANQGQGPGPMANNAGPQGNLNQMLNMPPGMQKNPNITMGQGQQMFNVNRGVGGQQQFLRQSPSPSTVSSPANSLNVQQQQQQQMQQQVANNQQQMQQQPNQNIVPQNTIPNQQMIPSPALVPIASPQMSGLMQNPNQRQQMRQSPSAPVNTPGQVTQNSPFNPQEDQLYREKYK
40
472










Molecular Recognition Features






MoRF SequenceStartStop




NANANA