<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10768

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMADDWQSQKIRQNIINKINDLLQNTGQDISKARVMENHIFKKSKSKDEYLGMVAKLFTHFKGMPNRRPQQAPPPNAEVPQQNMMQDPLNALQNLASQGNRNPQMMSMPGGGPNAQQGGQGPSGPVPASNLLQTLKQQRPGQQMQQMPGLRTQMVMGGAVGPGQQQVNMGPGQQMMGGPMGVQMNVMGGPNLGPNQQMVGNTQMGGATGGPGNVGVGPGGPQGMVPGQMNQMGGPGTVGPMGPNAGPGGPNQMQIGMQHPQLNQMINARMNQGGPGGQMNVGGHAGPNQGMQGLPPNMQQNQAGVGGAGGGPMHMGNMGQGNASQGQGPGAIANNAGPQGNLNQMLNMPPGMQKNPNITMGQGQQMFNVNRGVGGQQQFLRQSPSPSTVASPASSLNVQQQQQQQQQQQQMQQQVVNNQQQMQQQANQNVVQQNTIPNQQMIPSPALVPIASPQMSGLMQNPNQRQQMRHSPSASINTPGQVTQNSPFNPQEDQLYREKYKQLTKYIEPLKRMVDKLRIDGNNNAENYKKMNKLLEILKNPSQRVPLETLLKCEKVLENTDMDSYSDHSFGKSSNPLMEVINATLQSPMANHTLYRTFRPSLELLFGTDIAAPPAKMPRPAEKPPKGDLEIPHVLQGEIARLDKKFKVSLDPAAQNNPESIRLICCLDDKKLPCVPPVSINIPEDYPWSSPECSLIEHDYSATPFLKAVQNALVARIAKLPKLHSLSHLLDTWEMSVRQACSPNAAKPICEFTALFGM
Length757
PositionTail
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.03
Grand average of hydropathy-0.697
Instability index52.80
Isoelectric point9.41
Molecular weight81839.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10768
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.04|      19|      20|     155|     174|       1
---------------------------------------------------------------------------
  155-  174 (38.59/12.93)	MGGAVGPgQQQV....NMGPGQQM
  175-  197 (30.45/ 6.07)	MGGPMGV.QMNVmggpNLGPNQQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     532.21|     107|     121|     187|     304|       2
---------------------------------------------------------------------------
   51-  140 (95.51/18.19)	.......................................GMVAKLFTHF.KGmpnrrPQQAPP..PNAEV..P.QQ...NM..MQ.DP.LNALQNL.ASQGNRNPQM.MSM.PGGGPNaqQGGQG.PsgP......vpasNLlqtlKQQRPG
  186-  303 (201.14/51.99)	MGGPnlgpnqqmVGNTQMGGATGGP...GNVGVGpGGPQGMVPGQMNQM.GG.....PGTVGPMgPNAGPGGP.NQ...MQIGMQ.HPqLNQMINARMNQGGPGGQM.NVG.GHAGPN..QGMQGLP..P..........NM....QQNQAG
  304-  401 (105.84/21.07)	VGG.................AGGGPmhmGNMGQG.NASQG..........QG.....PGAIA...NNAGPQGNlNQmlnMPPGMQkNP......NITM...GQGQQMfNVNrGVGGQQ..QFLRQSP.sPstvaspasslNV....QQQQ..
  402-  493 (129.73/27.49)	QQQQqqqqmqqqVVNNQQQMQQQAN...QNV.V....QQNTIPNQ..QMiPS.....PALV.PI...ASP.....Q...MSGLMQ.NP..NQRQQMR...HSPSASI.N......TPG..QVTQNSP..F..........NP....QEDQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.29|      21|      23|     637|     658|       3
---------------------------------------------------------------------------
  637-  658 (32.54/27.05)	EIARL.DKKFKvSLDPAAQNNPE
  662-  683 (36.74/25.47)	LICCLdDKKLP.CVPPVSINIPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.20|      34|      64|     497|     537|       4
---------------------------------------------------------------------------
  503-  537 (51.99/51.96)	TKYIePLKRMVDKLRIDGNNNAENY......KKMNKLLEIL
  541-  580 (50.21/30.33)	SQRV.PLETLLKCEKVLENTDMDSYsdhsfgKSSNPLMEVI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10768 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNIINKINDLLQNTGQDISKARVMENHIFKKSKS
2) VAKLFTHFKGMPNRRPQQAPPPNAEVPQQNMMQDPLNALQNLASQGNRNPQMMSMPGGGPNAQQGGQGPSGPVPASNLLQTLKQQRPGQQMQQMPGLRTQMVMGGAVGPGQQQVNMGPGQQMMGGPMGVQMNVMGGPNLGPNQQMVGNTQMGGATGGPGNVGVGPGGPQGMVPGQMNQMGGPGTVGPMGPNAGPGGPNQMQIGMQHPQLNQMINARMNQGGPGGQMNVGGHAGPNQGMQGLPPNMQQNQAGVGGAGGGPMHMGNMGQGNASQGQGPGAIANNAGPQGNLNQMLNMPPGMQKNPNITMGQGQQMFNVNRGVGGQQQFLRQSPSPSTVASPASSLNVQQQQQQQQQQQQMQQQVVNNQQQMQQQANQNVVQQNTIPNQQMIPSPALVPIASPQMSGLMQNPNQRQQMRHSPSASINTPGQVTQNSPFNPQEDQLYREKY
12
53
45
499










Molecular Recognition Features






MoRF SequenceStartStop




NANANA