<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10767

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMADDWQSQKIRQNIINKINDLLQNTGQDISKARVMENHIFKKSKSKDEYLGMVAKLFTHFKGRPQQAPPPNAEVPQQNMMQDPLNALQNLASQGNRNPQMMSMPGGGPNAQQGGQGPSGPVPASNLLQTLKQQRPGQQMQQMPGLRTQMVMGGAVGPGQQQVNMGPGQQMMGGPMGVQMNVMGGPNLGPNQQMVGNTQMGGATGGPGNVGVGPGGPQGMVPGQMNQMGGPGTVGPMGPNAGPGGPNQMQIGMQHPQLNQMINARMNQGGPGGQMNVGGHAGPNQGMQGLPPNMQQNQAGVGGAGGGPMHMGNMGQGNASQGQGPGAIANNAGPQGNLNQMLNMPPGMQKNPNITMGQGQQMFNVNRGVGGQQQFLRQSPSPSTVASPASSLNVQQQQQQQQQQQQMQQQVVNNQQQMQQQANQNVVQQNTIPNQQMIPSPALVPIASPQMSGLMQNPNQRQQMRHSPSASINTPGQVTQNSPFNPQEDQLYREKYKQLTKYIEPLKRMVDKLRIDGNNNAENYKKMNKLLEILKNPSQRVPLETLLKCEKVLENTDMDSYSDHSFGKSSNPLMEVINATLQSPMANHTLYRTFRPSLELLFGTDIAAPPAKMPRPAEKPPKGDLEIPHVLQGEIARLDKKFKVSLDPAAQNNPESIRLICCLDDKKLPCVPPVSINIPEDYPWSSPECSLIEHDYSATPFLKAVQNALVARIAKLPKLHSLSHLLDTWEMSVRQACSPNAAKPICEFTALFGM
Length753
PositionTail
OrganismMusca domestica (House fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Muscoidea> Muscidae> Musca.
Aromaticity0.03
Grand average of hydropathy-0.691
Instability index51.68
Isoelectric point9.35
Molecular weight81340.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10767
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      19|      20|     151|     170|       1
---------------------------------------------------------------------------
  151-  170 (39.30/13.24)	MGGAVGPgQQQV....NMGPGQQM
  171-  193 (31.07/ 6.24)	MGGPMGV.QMNVmggpNLGPNQQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.12|      30|      31|     198|     227|       2
---------------------------------------------------------------------------
   99-  142 (42.70/ 9.70)	QMMSMPGGGP...NAQQGGQGP.SGP..VPAsnllqtlkqqrpgqQM..QQM
  198-  227 (64.64/18.91)	QMGGATGGPG...NVGVGPGGP.QGM..VPG..............QM..NQM
  264-  298 (34.79/ 6.38)	RMN..QGGPGgqmNVG.GHAGPnQGMqgLPP..............NMqqNQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.69|      31|      34|     321|     351|       4
---------------------------------------------------------------------------
  336-  370 (46.46/13.21)	NLNQMLNMPPGMQKNPnitmGQGQQMFNVNRG..VGG
  390-  415 (40.94/10.70)	SLNVQQQQQQQQQQQQ....MQ..QQVVNN.....QQ
  452-  486 (35.29/ 8.13)	GLMQNPNQRQQMRHSP.sasINTPGQVTQNSPfnPQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      83.69|      22|      42|     524|     547|       5
---------------------------------------------------------------------------
  496-  514 (20.69/ 7.90)	........................KQLTKYIEPL.....KRMVDKLRI
  515-  542 (25.88/12.54)	DG...............nnnaenyKKMNKLLEIL.....KNPSQRVPL
  543-  584 (18.94/10.19)	ETLlkcekvlentdmdsysdhsfgKSSNPLMEVI......NATLQSPM
  587-  613 (18.18/ 6.57)	HTL....................yRTFRPSLELLfgtdiAAPPAKMP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.73|      27|     166|      62|      89|       7
---------------------------------------------------------------------------
   62-   89 (50.00/22.80)	GrPQQAPP..PNAEVPQQNM....MQDP.LNALQN
  229-  262 (41.74/14.77)	G.PGTVGPmgPNAGPGGPNQmqigMQHPqLNQMIN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10767 with Med15 domain of Kingdom Metazoa
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