<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10758
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MLIAPTAVRDWERLGLEPYSRPKKLQFVVLAPVQASRVLKKAVRRTMSELTVAFADCKLGEHSPVALSTDGDFFLDTGRLESTELPPNCVVYMLVRGQTEACQLRDTVAKLTGGAVPVPLSTRLLLAPAKGDLRALALRVYTQVPKRVPYPTDGRSLCGFGPLKDRESCQRELGMTGPVSLFAPPYVLHASSDEPVLLCAYCLSEDRRWLLATLTDERGELNYRRLINLRVPDCHRRRKASTKQLGPERLLEWICDLPETRAQRWRLVLSRLGRLGHGELLVWADLLKRASLQQRGARSAALCAVDADPHLRVLPDQLSREGPQRGPPSVGADR |
Length | 334 |
Position | Middle |
Organism | Macrostomum lignano |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes>
Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.243 |
Instability index | 51.96 |
Isoelectric point | 9.48 |
Molecular weight | 37208.77 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP10758
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.18| 12| 51| 58| 69| 1
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58- 69 (22.67/11.50) KL.GEHSPVALST
110- 122 (18.50/ 8.31) KLtGGAVPVPLST
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 114.63| 28| 29| 272| 299| 2
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244- 264 (24.36/ 8.29) ..QL.GPERLLEWICDLPETRAQR.....
272- 299 (47.61/22.16) LGRL.GHGELLVWADLLKRASLQQRGARS
302- 329 (42.67/19.21) LCAVdADPHLRVLPDQLSREG.PQRGPPS
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