<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10753

Description Uncharacterized protein
SequenceMSMPSFPSLETLSLKKARLERKPLGPPEVYPQMPNQDEDKLDQVNVREGFKDILQNRFKSTKLEEYSSIAKDFNCSSENVLGAFKKIVQRKVDVNVMPDTSKRRGAISKDISLPMAGRTASKVEEWFKDFKSGEQLTKLSAKVPLSVKKEDILKEVFKNRLPVHRAIWYLKVWWQFSSSLSESSKKKKPFDAPEVQVKNDICTHLKDTFEAAVDGADEDVQDEWNYVWDLLVAMLDQSLFEQLEILRWVTEFIERCRRSENQLAFLLPHLLAVVQHFSTSELESRRFLGVCCSVVRDLSSVVDLQFAQRSQCPQHYQILLSVTSLIVTTILRCPESAVWSAAVSCESPLYGSPLDRLPCNLLCLPVPPKLLDPLRQLMLEIINRSAEAEQHWTRRVDSPDTLRLIEVLEHLDKHDYMSEDNKEALQQGESEMPLQDKDIMHNLFTKCFDREDPESDLRVANLLCQWAVHPSRGGCHRPVVAAVLMEKLRLLNRVDPVRLHDQLVSFLNSDSAPRQDRDSGPDCQEPFRNLVALFGELIDREIFDHDSYARYLIAHDILSSEKAPLVFSETEYSPPGLAQQPSKHIQYLAHFPLPADDTYAHEASQRLHMLYGVGKSEEALKRFLRRLVREVSRLFTKKHNLMDASTGMYAKQRRAGSADEDAELNDIKRRFSMLTFCEMELVTAQGKRSLMESLRQFYEDPSCNILPSPSRMLFLVTLVELSGNLTGLIYFLVEISNSILKVENKVCPGSAAAAGAAMPVTPEEQQRNNFLRMWSNKVVLRVLGYLRQYQAILMTMPAEMRALFSNLVRTNVKKVGNPEQCSCADRCTLAYLFDLYSQSISVKAGFHNIFSRARPKLKQAIYKKIEAYEIPQAKFPPTLMNLTHPSIEELLLNDEEERKRANSSEEEKRTNFFSYYLYNVLMCDTDEKVLKTCVEACECTTFCAQLPPRWLWILRALLNSASGSAKFEPVLPQMLRDLVCNCPNLAEKLSVLCGLLLSRTCFTIADFVTNVLFPCDYLKNQSAEPSARLAIHVFYLIVTLKLPLTSLTDKLLLRGAVVDKISSNSLSFFLKVLLLIPGDSWLECVQREAARESPVDLRSLRFADFAARVYKEITDSAWIREKFLRQPFTETLLSKEALLDSFITDSQARFILHSIAYRCPTPQRAEMTGSSVASFSDFWRQTQNFSHLFKGLSLWYLTWSLLEVELSLLRLISGPGDLDSTQRQFANSLCEFFSHRVAPVLKSETAATPTPSGGSQAYQLQHHQQLHQPPPPPGLPLIEPVETDWLVSLLIRKLSSHSLGPSIRAQIVKSAGSLLDCGASFSNAKADHEREDMLRRSSVLLAYPPFLCLLQESLAEESVRLDILSPGTQSGLFQQINRYIEHAEKALDSGIEEDLRVRCLLGQALRLRLSLVGSLFGVLLQNTSLCAEWSMLLAKLVTHSVVDIGSSREDFHRVIDMLVSLLHAVATGPPGSDPERQPTLDDERKNLLGVVKKLRKELKDSDLLPAPLRPLFVTPRLTFEVPVCRIARRPASCVLHGREHMSPLELIEGVKTFQPLSLSWYTAMRYDLPPSRHELAHLVAPLTRAGAGARPVRDERYYLRSPDLPEEDLVPDEPKKMKMSNGLPAVPHQQMQHPQHPMHSQHQHPGQIPYHMMTPQQQHHHHHHHIHQQQLQHQHAHQHAQMQHQHTHQPPHPPHQQQHQPHQPLHQQLHQNPHQNLHSQHSHQPPPLPPPAPQTTGRKS
Length1740
PositionKinase
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.335
Instability index56.43
Isoelectric point6.97
Molecular weight198099.21
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10753
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.74|      20|      98|     349|     368|       1
---------------------------------------------------------------------------
  349-  368 (41.77/29.55)	LYGSPLDRL.P......CNLLC.LPVPP
  443-  470 (26.98/15.62)	LFTKCFDREdPesdlrvANLLCqWAVHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     271.89|      55|      98|    1572|    1627|       2
---------------------------------------------------------------------------
 1219- 1275 (60.66/29.40)	DstQRQ.FAnslceffsHRVAPV..LKSETAATP.TPsggSQAYQLQHH....QQLHQPP..........PPPGL
 1572- 1626 (76.54/43.01)	...RHE.LA........HLVAPL..TRAGAGARPvRD...ERYYLRSPDLPEEDLVPDEPKK...MKMSNGLPAV
 1627- 1656 (33.51/12.44)	P...HQqMQ........HPQHPMhsQHQHPGQIP........YHMMTPQ..........................
 1672- 1728 (101.18/54.71)	...QHQ.HA........HQHAQM..QHQHTHQPP.HP...PHQQQHQPHQPLHQQLHQNPHQnlhSQHSHQPPPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.84|      35|     229|    1158|    1202|       8
---------------------------------------------------------------------------
 1158- 1202 (52.91/53.75)	RCPTPQRAEMTGSSVASFsdfwrqtqnFSHLFKGLSLwYLTWSLL
 1398- 1432 (61.94/35.80)	RCLLGQALRLRLSLVGSL.........FGVLLQNTSL.CAEWSML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.77|      53|     954|     493|     546|      15
---------------------------------------------------------------------------
  493-  546 (90.85/52.20)	RVDPVRLHDQLVSFLN..SDSAPRQDRDSGPDCQEPFRNLVALFGELiDREIFDHD
 1448- 1502 (86.91/46.06)	REDFHRVIDMLVSLLHavATGPPGSDPERQPTLDDERKNLLGVVKKL.RKELKDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.14|      17|      19|     298|     314|      17
---------------------------------------------------------------------------
  298-  314 (30.03/18.05)	LSSVVDLQFAQRSQCPQ
  319-  335 (28.11/16.42)	LLSVTSLIVTTILRCPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10753 with Med12 domain of Kingdom Metazoa
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