<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10747

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTFAGHGYLAKHCFLRSDLESELCPFCEYNNEDAQHFVTALFYQRPAALPRAKPSARPNLNKSSRLRFSASASRASGSLPFAPARFPLPAPEFAPLPALTLALGRAALGTSAGLSAALPAAFPAFAAFTAFPTFTALPALLLPSAAALPGATGAGMDLHFRPLISGLKCAACFRSQKLQRLSARGWSRLTDEAVSGNAGRNDQGQCTKALHASLKEIHYRRYRIAQPVESAHTCSDPVFSSFAKCQRCGILSAWKRYLPDTGDPSKPYDYGNYEKELWVFWHGGHDPPQLRDSLAHDLTPWSDSSDGGGISYEVRTMLFKAVHNCIERCLTGKGYVRLGQWFVRPLVPGLCLDPAVTQQFSLALNYFLHGESVCAAVDAKLYPPVHSLTKQQCQARTPVILSPHGIAGELTGREWDSQNQIESLVWREFFPHVRTDRGFVEVAVGQHRLWYPVDLLFATQAPLPPEPLSQIELNLAAESSADACLQHLLGCQGSDANGVHQQQQQQRCTCRRRTKPRPALTSAYHNRFFQATERTVDREPAMPTLSPQEPLSVEESEAAAAAASGAASIPTADGVGQQPSLKGLPKSEPISPPAAASVEAAKSQGDGVGLMDDESQQQQTQAAAASALAESSSSRPASVKTPQSQPTGSESQPASAAAAAAAPTPPLPPPPPPPPTSSAQQQQQQQPPPLPASSMPNGQASSVAADSLLEPGLGWLSVVQQSLRKRPLPQLEPWEADLNDSGHDVVSELPEWTSLAAYAKHARLLLPARGILNGPASSANATAAGSVGGSGAASGVALPIDDSASPSGIGSLVGLRSSPSKAGLSADSKSTAVSLKSEDILKVENLQMQSIFEVESPEPLDNANAACEGPGLHGNPSSSGCVIGGTSMASCGGSGTLPASDLCRIYPTPPSLENHIHPSPAPETDQANMLSPAAAAAGHHHHHHHASADCGSGPDLANDDDWSFLTSQRHQGGSLGQLFTAQNPPMPHLSIVYVPELPQTHRPHRAAAAAAGHAGGGHYGIGQQIAATPSSASVTAVGHMPAGTPVTPGSFAAVATPASVRTPGQAGTPCGSIVGEQLDQSQLSTGHQSIQASQAQPVEALRLNLLLSDSLLCLCRDQNFEACNICVCHGDLTGSEAGLYMPGLLDRRPSPCQCGFSASANRALGLGSNIFYEDLCDLLGDRRRLDYRPWPSTYSPAVIDSLLNFVSLTIPLRQFRSPPAQQQQSQSDATNSAVAVVAGAAAAAGAATADPAASSSLHPGHLAQFEDCNEAAKLVLQACTQGLHQPQQQQQPFSLAEQPTLLHRWSLTGQLPTAGSDLVRLLKSLRPWFQDSLWGKALQGNYWVTGPMTWQEFHQFARRGSEESCEPQPLPLISVYTDRDEGMLIAPTAVRDWERLGLEPYSRPKKLQFVVLAPVQASRVLKKAVRRTMSELTVAFADCKLGEHSPVALSTDGDFFLDTGRLESTELPPNCVVYMLVRGQTEACQLRDTVAKLTGGAVPVPLSTRLLLAPAKGDLRALALRVYTQLGERLLEWICDLPEPELNAGGLWPAGHGELLVSAAAGADRRGFRVLLRPPNPFPAALRLLGPVCRFAQLPVPGRSLCLRASLHLNQLASCDRAPLSAACDRSPTHPLNTYKTTEVLRYVLETCHSLSWLSVDPATGDRVSCLPRHINQLFLLYHSVH
Length1682
PositionMiddle
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.06
Grand average of hydropathy-0.221
Instability index58.31
Isoelectric point6.41
Molecular weight179037.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10747
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     227.11|      37|      73|     909|     945|       2
---------------------------------------------------------------------------
  540-  565 (29.72/ 8.02)	.PAMPT.LS....PQEPLSVEES.EAAAAAASG.....
  636-  663 (38.66/12.83)	PASVKTPQS...QPTGSESQPAS.AAAAAAAP......
  856-  876 (30.18/ 8.27)	..........SPEP.LDNAN......AACEGPGLHGNP
  909-  945 (69.75/29.56)	PPSLENHIHPSPAPETDQANMLS.PAAAAAGHHHHHHH
  984- 1019 (58.81/23.67)	PP.MP.HLSIVYVPELPQTHRPHrAAAAAAGHAGGGHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     803.46|     231|     364|    1022|    1271|       3
---------------------------------------------------------------------------
  691-  807 (100.80/37.43)	..........................................PASSMPNGQ...ASsvaADS...LlEPGL..GWLSV.VQQSLRKrplPQLEPWEA.DLN...............................................................................................dsghdVVSELPEWTSLAAyakharlllPARGILNGPA......SSANATAAGSVGGSGAASGVAlPIDDSASPS................
 1022- 1271 (364.87/193.09)	GQQIAATpSSASVTAVGHMPAGTP.......VTPGSFAAVATPASVRTPGQ...AG...TPCGsiV.GEQLDQSQLST.GHQSIQA...SQAQPVEALRLNLLlsdsLLCLCRDQNfEACNICVCHGDLTGSEaglyMPGLLDRR..PSPCQCGFSASANRALG.LGSNIFyEDLCDLlgDRRRLDYRP.WPSTYS...paVIDSLLNFVSLTI.........PLRQFRSPPAqqQQSQSDATNSAVAVVAGAAAAAGAA.TADPAASSSLHPG.HLAQFEDCNEA
 1382- 1618 (337.80/144.23)	GMLIAPT.AVRDWERLGLEPYSRPkklqfvvLAPVQASRVLKKAVRRTMSEltvAF...ADCK..L.GEH.SPVALSTdGDFFLDT...GRLESTE.LPPNCV....VYMLVRGQT.EACQLRDTVAKLTGGA....VPVPLSTRllLAPAKGDLRALALRVYTqLGERLL.EWICDL..PEPELNAGGlWPAGHG........ELLVSAAAGA.........DRRGFRV.....LLRPPNPFPAALRLL..GPVCRFAQ.LPVPGRSLCLRASlHLNQLASCDRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.91|      35|      38|      76|     113|       4
---------------------------------------------------------------------------
   46-   73 (39.91/13.14)	.......PAALPRAK.....P..SARPNLNKS.SRLRF.S.ASAS
   76-  113 (56.95/30.16)	SGSLPfaPARFPLPA.....PEFAPLPALTLAlGRAAL.G.TSAG
  115-  155 (47.05/17.31)	SAALP...AAFPAFAaftafPTFTALPALLLP.SAAALpGaTGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.96|      28|      28|     576|     603|       5
---------------------------------------------------------------------------
  576-  603 (46.80/27.32)	GQQPSLKGLPKSEPISPPAAASVEAAKS
  605-  632 (45.17/26.06)	GDGVGLMDDESQQQQTQAAAASALAESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.43|      17|      37|     264|     280|       6
---------------------------------------------------------------------------
  264-  280 (34.98/23.59)	P..............SKPYDYG..NYEKELWVF
  287-  319 (17.45/ 7.55)	PpqlrdslahdltpwSDSSDGGgiSYEVRTMLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10747 with Med13 domain of Kingdom Metazoa
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