<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10746

Description Uncharacterized protein
SequenceMKPNQPPPLPPHSNLPTSHFSAAAAAASLQHHQHHQHQLLQQTRADNEERQRFQVELEFVQCLGNPNYLNFLAQRRFFEKREFINYLSYLQYWKEADYVKYIKYPFCLQLLDLLQHQQFRKDIAKTGLAREILNCLAECVSQLSALHRTLRNEKQLRLNDFALLPIGLSPQLDQHLLNHTEGRLGLLNHDSVPHYLRTKLDLSVEHRRNEFQKSSTNIEAQPRTSEQMRKAAETALNSLKQARPDFENEQSERNQTMRSNEQDTAKLLLAINFAFSTEQPFSSYKLDNNDSELLLGYASRLLGCQSRSGSAATTAAAAAILSQQPVRHKSPLQKVRKRGPFPEWTKTDPDPHLFTRHIPKTDERRTKAVRPPGKYQIFSVHYDPIVNSFAGHFVKCGERDKLRDVFTQMMAEIKHIQMARRNAAPPEEKASIEASSLWDWKSLGVDPTRVIHKAVENCSPLLIIKHVFRGGFLYKVPCPLRESESQMRAFKFLRIASNVRGTKEHLYRSLARELVNASNNEGKAVHAKLQLHKTCEENRAYANYPPMQTAIHGADSLCNPGGNSEEQQMPPPPPLSPPAVHQDDDKDELDEAPSFAESALLKQRSRRRWLRRIRRRQAIRRHSLAHLFGLLHPDQLSRVLGKSGFDPEAYVTGIRRLAAPPPPKLPSSLLLSMTSAATASKAAAPVSDDATKAATTATSNAGPTATSVLRHRRVQSAGGDSSTSEAVQKSAEEVAASLLSTQDAAGNTRNPADFKNIFLKGTQSANPHNDYSQHFVDTGLRPQNFIRDAGLANRFAEYPKLRELIRLKDELVKETATPPMYLKCDLLTFNLNDLNCKFDAILVEPPLEEYNISHGVYYPRYWSWDEIEQLKIEEITAPRCFVWLWCGNGESLEHGRRCLRKWGFRRCEDICWIKTNKGRPGHKLVEAETALFQQTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIMHEEPGWGQKAHPAELFNIIEHFCLGRRRLHLFARDDTVRKGWLSLGPELAASNFDSRIYSGYFSRDAQAHLTGCTEEIERLRPKSPPPRNSAAGGKSASADDAGGGGSSGGPSVAIGAMQQPATIYPMQPPPPPGIIAPAATVPNPMQ
Length1114
PositionHead
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.08
Grand average of hydropathy-0.602
Instability index58.73
Isoelectric point9.07
Molecular weight125427.67
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
ribosome	GO:0005840	IEA:UniProtKB-KW

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10746
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     859.64|     292|     525|     206|     579|       1
---------------------------------------------------------------------------
  206-  569 (419.36/389.74)	HRRneFQKSStnieAQPRTSEQMRKAAETALNSL...KQARPDFENEQSERNQTMRSNE.......................QDTAkllLAINFAfstEQPfSSYKLDNNDSEL..............LLGYASRLLGCQSrsgsaattaaaAAILSQQPVRHKSPLQKVRkrgpFPEWTKTDPDPHLftrhipktderRTKAVRPPgkyQIFSVHYDPIVNSFAgHFVKCGERDKLRdvftqmmaEIKHIQMARRNAAPPEEKAsIEAsslwdwkslgvdPTRVIHKAVENCspLLIIKHVFR....GGFLY.KVPCPLRESE......................SQMRAFKFLRIASNVRGtkehlYRSLARELVnASNNEGKAVHAKL....QLHKT.CEE..NRAYANYPPMQTAI...........HGADSLCNPG...GNSEE......QQM
  711- 1096 (440.28/259.03)	HRR..VQSAG....GDSSTSEAVQKSAEEVAASLlstQDAAGNTRNPADFKNIFLKGTQsanphndysqhfvdtglrpqnfiRDAG...LANRFA...EYP.KLRELIRLKDELvketatppmylkcdLLTFNLNDLNCKF...........DAILVEPPLEEYNISHGVY....YPRYWSWDEIEQL...........KIEEITAP...RCFVWLWCGNGESLE.HGRRCLRKWGFR........RCEDICWIKTNKGRPGHKL.VEA............ETALFQQTKEHC..LMGIKGTVRrstdGDFIHaNVDIDLIMHEepgwgqkahpaelfniiehfclGRRRLHLFARDDTVRKG.....WLSLGPELA.ASNFDSRIYSGYFsrdaQAHLTgCTEeiERLRPKSPPPRNSAaggksasaddaGGGGSSGGPSvaiGAMQQpatiypMQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     196.04|      53|     563|       3|      84|       2
---------------------------------------------------------------------------
    6-   59 (94.02/42.51)	PPPLPPHSNLPTSHFS........AAAAAASLQHHQHHQHQLLQQTRADNEERQRFQVELeF
  570-  628 (84.92/30.42)	PPP.PPLSP.PAVHQDddkdeldeAPSFAESALLKQRSRRRWLRRIRRRQAIRRHSLAHL.F
  661-  679 (17.10/16.36)	PPPKLP.SSLLLSMTS........AATA..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.29|      19|      25|     143|     165|       3
---------------------------------------------------------------------------
  143-  164 (26.14/27.46)	LS.ALHRTLRNEKQLRLndfALL
  168-  187 (29.14/13.90)	LSpQLDQHLLNHTEGRL...GLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10746 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FQKSSTNIEAQPRTSEQMRKAAETALNSLKQARPDFENEQSERNQTMRSNEQD
2) GCTEEIERLRPKSPPPRNSAAGGKSASADDAGGGGSSGGPSVAIGAMQQPATIYPMQPPPPPGIIAPAATVPNPMQ
3) HGADSLCNPGGNSEEQQMPPPPPLSPPAVHQDDDKDELDEAPSFAES
4) SKAAAPVSDDATKAATTATSNAGPTATSVLRHRRVQSAGGDSSTSEAVQKSAEEVAASLLSTQD
5) TTAAAAAILSQQPVRHKSPLQKVRKRGPFPEWTKTDPDPHLFTRHIPKTDERRTKAV
211
1039
552
680
313
263
1114
598
743
369










Molecular Recognition Features






MoRF SequenceStartStop




NANANA