<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10741

Description Uncharacterized protein
SequenceMKPNQPPPLPPHSNLPTSHFSAAAAASLQHHQHHQHQLLQQTRADNEERQRFQVELEFVQCLGNPNYLNFLAQRRFFEKREFINYLSYLQYWKEADYVKYIKYPFCLQLLDLLQHQQFRKDIAKTGLAREVDEQILLHWQHYIPKRHRLLTRQANQQLLEQQEQQQQGVDGGSHQQLAGREGGGGNRGSDDCLDELIDRLRGIRRTLCSLIAKVDEKRPATWPELSALHRTLRNEKQLRLNDFALLPIGLSPQLDQHLLNHTEGRLGLLNHDSVPHYLRTKLDLSVEHRRNEFQKSGTNIEAQPRTSEQMRKAAETALNSLKQARPDFENEQSERNQTMRSNEQDTAKLLLAINFGIGLNRLLGCQSRSGSAATTAAAAAILSQQPVRHKSPLQKVRKRGPFPEWTKTDPDPHLFTRHIPKTDERRTKAVRPPGKYQIFSVHYDPIVNSFAGHFVKCGQRDKLRDVFTQMMAEIKHIQMARRNAAPPEEKASIEASSLWDWKSLGVDPTRVIHKAVENCSPLLIIKHVFRGGFLYKVPCPLRESESQMRAFKFLRIASNVRGTKEHLYRSLARELVNASNNEGKAVHAKLQLHKTCEENRAYANYPGTAQIPLCNPGGNSEEQQMPPPPPPPPPLSPPAIHQDDDKDELDEAPSFAESALLKQRSRRRWLRRIRRRQAIRRHSLAHLFGLLHPDQLSRVLGKSGFDPEAYVTGIRRLAAPPPPKLPSSLLLSMTSAATASKAAAPVSDDATKAATTATSNAGPTATSVLRHRRVQSAGGDLSTSEAVQKSAEEVAASLLSTQDAAGNTRNPADFKNIFLKGTQSANPHNDYSQHFVDTGLRPQNFIRDAGLANRFAEYPKLRELIRLKDELVKETATPPMYLKCDLLTFNLNDLNCKFDAILVEPPLEEYNISHGVYYPRYWSWDEIEQLKIEEITAPRCFVWLWCGNGESLEHGRRCLRKWGFRRCEDICWIKTNKGRPGHKLVEAETALFQQTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIMHEEPGWGQKAHPAELFNIIEHFCLGRRRLHLFARDDTVRKGWLSLGPELAASNFDSRIYSGYFSRDAQAHLTGCTEEIERLRPKSPPPRNSAAGAKSASADDAGGGGGQSVAIGAMQQPATIYPMQPPPPPGIIAPAATVPNPMQ
Length1171
PositionHead
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.646
Instability index57.73
Isoelectric point9.22
Molecular weight132199.38
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
ribosome	GO:0005840	IEA:UniProtKB-KW

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10741
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.85|      70|     523|     452|     639|       1
---------------------------------------------------------------------------
  457-  541 (107.37/193.50)	CGQRDKL...RDVFTQM.MAEIKHIQMARRNAAPPEEKAsIEAsslwdwkslgvdPTRVIHKAVENCspLLIIKHVFR....GGFLY.KVPCPL
  946- 1024 (110.48/31.57)	CGNGESLehgRRCLRKWgFRRCEDICWIKTNKGRPGHKL.VEA............ETALFQQTKEHC..LMGIKGTVRrstdGDFIHaNVDIDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.07|      39|     523|     601|     639|       2
---------------------------------------------------------------------------
  601-  639 (80.30/32.72)	AYANY.PGTAQIPLCNPGGNS....EEQQ....MPPPPPPPPPLSPPA
 1085- 1116 (39.74/13.04)	.YSGYfSRDAQAHLT..GCTE....EIER....LRPKSPPPRN.....
 1118- 1163 (57.03/21.43)	AAGAK.SASAD.DAGGGGGQSvaigAMQQpatiYPMQPPPPPGIIAPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.82|      12|      16|     734|     745|       3
---------------------------------------------------------------------------
  734-  745 (20.51/13.32)	TSAA.TASKAAAP
  751-  763 (17.31/10.00)	TKAAtTATSNAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     333.30|      80|      84|     106|     185|       5
---------------------------------------------------------------------------
  106-  185 (136.85/74.92)	CL.QL.LDL.LQHQQFRKDIAKTGLAREVDEQILLHWQHYIPKRHRLLT.RQANQQLLEQQEQQQQGVDGGSHQQ......LAGR.EGGGG
  192-  267 (107.86/57.54)	CLdEL.IDR.L..RGIRRTL..CSLIAKVDEKRPATWPE.LSALHRTL..RNEKQLRLNDFALLPIGLSPQLDQH......LLNHtEGRLG
  277-  358 (88.59/45.99)	YL.RTkLDLsVEHR..RNEFQKSG..TNIEAQPRTSEQMRKAAETALNSlKQARPDFENEQSERNQTMR..SNEQdtakllLAIN.FGIG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.78|      46|     287|     373|     433|       6
---------------------------------------------------------------------------
  373-  432 (62.55/65.47)	ATTAAAAAILSQQPVRHKspLQKVRKR..................gpfpewtKTDPDPHLFTRHIpktdeRRTKAVRP
  652-  722 (67.23/35.45)	APSFAESALLKQRSRRRW..LRRIRRRqairrhslahlfgllhpdqlsrvlgKSGFDPEAYVTGI.....RRLAAPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.54|      10|      15|     777|     786|       7
---------------------------------------------------------------------------
  777-  786 (17.23/ 9.79)	AGGDLSTSEA
  795-  804 (16.32/ 8.91)	AASLLSTQDA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10741 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GCTEEIERLRPKSPPPRNSAAGAKSASADDAGGGGGQSVAIGAMQQPATIYPMQPPPPPGIIAPAATVPNPMQ
2) GTAQIPLCNPGGNSEEQQMPPPPPPPPPLSPPAIHQDDDKDELDEAPSFAES
3) HRRNEFQKSGTNIEAQPRTSEQMRKAAETALNSLKQARPDFENEQSERNQTMRSNEQD
4) SKAAAPVSDDATKAATTATSNAGPTATSVLRHRRVQSAGGDLSTSEAV
5) TTAAAAAILSQQPVRHKSPLQKVRKRGPFPEWTKTDPDPHLFTRHIPKTDERRTKAVR
1099
607
288
740
374
1171
658
345
787
431










Molecular Recognition Features






MoRF SequenceStartStop




NANANA