<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10738

Description Mediator of RNA polymerase II transcription subunit 7
SequenceQLQMSDSSRISAFPLPPMQYVNCYTDERVHSGTAPPPPRPLDSSYAMFGMPCTKEDAVIHSLESQGIRRLYPALYDHKRELKKLNFSILANYLDLMDIVVKCPDSQERLQKLEHMKTLFINVHHLINEYRPLQARDTLIEMLSLQSSVTHQSVDTASRYLARADAVVGRAAAASVGGDEDEPMRGADEAAGGEISQALLNDIDKLSAELSELTAAAAELDDAESAGFDLFASRGDDGNGDEAAGDSATDDVELEVDSDETSEDDDEADEAGEAVVNLPAGHQAAVGFSSTGNDAASGSLAQAPAAEAAVGASDEAPSVLDDLDSLLAFN
Length329
PositionMiddle
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.05
Grand average of hydropathy-0.339
Instability index41.75
Isoelectric point4.19
Molecular weight35045.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


ECO:0000256	RuleBase:RU364060

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10738
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.23|      25|      25|     221|     245|       1
---------------------------------------------------------------------------
  221-  245 (44.96/19.58)	DAESAGF.DLFASRGDDGNGDEAAGD
  250-  272 (35.78/14.30)	DVELE.V.DSDETSEDDDEADE.AGE
  293-  315 (22.49/ 6.66)	DAASGSLaQAPAAEAAVGASDEA...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.45|      10|      25|      76|      85|       2
---------------------------------------------------------------------------
   76-   85 (17.03/12.68)	DHKRELKKLN
  104-  113 (16.41/11.97)	DSQERLQKLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.89|      17|      24|     178|     194|       3
---------------------------------------------------------------------------
  178-  194 (29.98/17.79)	DEDEPMRGADE..AAGGEI
  201-  219 (20.91/10.19)	DIDKLSAELSEltAAAAEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10738 with Med7 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGFDLFASRGDDGNGDEAAGDSATDDVELEVDSDETSEDDDEADEAGEAVVNLPAGHQAAVGFSSTGNDAASGSLAQAPAAEAAVGASDEAP
225
316










Molecular Recognition Features






MoRF SequenceStartStop




NANANA