<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10727

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLIAPTAVRDWERLGLEPYSRPKKLQFVVLAPVQASRVLKKAVRRTMSELTVAFADCKLGEHSPVALSTDGDFFLDTGRLESTELPPNCVVYMLVRGQTEACQLRDTVAKLTGGAVPVPLSTRLLLAPAKGDLRALALRVYTQVPKRVPYPTDGRSLCGFGPLKDRESCQRELGMTGPVSLFAPPYVLHASSDEPVLLCAYCLSEDRRWLLATLTDERGELNYRRLINLRVPDCHRRRKASTRQLGPERLLEWICDLPETRAQRWRLVLSRLGRLGHGELLVWADLLKRASLQQRGARSAALCAVDADPHLRVLPDQLSREGPQRGPPSVGADRRVSSAITHILVLPTSASFSQANPADFLGGSLGEPDLMNELLGDPGVLGGDTGNDLFNDLDLNFDIQLPDIEEPVVGPQGGDGSGQLMQQPLALGYYLSSAPPGPVPAWFRVAPPEQAAVCLRASLHLNQLASCDRAPLSAACDRSPTHPLNTYKTTEVLRYVLETCHSLSWLSVDPATGDRVSCLPRHINQLFLLYHSVH
Length534
PositionMiddle
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.06
Grand average of hydropathy-0.168
Instability index54.34
Isoelectric point7.54
Molecular weight58626.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10727
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.67|      24|      59|     198|     221|       1
---------------------------------------------------------------------------
  198-  221 (45.85/27.16)	LCAYC.LSEDR..RW..LLATLTD.ERGEL
  251-  280 (29.82/15.26)	LEWICdLPETRaqRWrlVLSRLGRlGHGEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.42|      30|      31|     285|     315|       2
---------------------------------------------------------------------------
  285-  315 (48.16/34.84)	DLLKRASlQQRGARS..AALCAVDADPHLRVLP
  316-  347 (49.27/31.03)	DQLSREG.PQRGPPSvgADRRVSSAITHILVLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.49|      21|      61|     442|     464|       3
---------------------------------------------------------------------------
  442-  464 (36.11/21.41)	WFRVAPPEQAAV.CLraSLHLNQL
  505-  526 (37.38/17.15)	WLSVDPATGDRVsCL..PRHINQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.91|      30|      31|      76|     105|       4
---------------------------------------------------------------------------
   76-  105 (54.56/28.63)	DT.GRLESTELP.PNCVVYML..VRGQTEACQLR
  106-  139 (35.35/16.32)	DTvAKLTGGAVPvPLSTRLLLapAKGDLRALALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.25|      28|      32|     368|     397|       5
---------------------------------------------------------------------------
  368-  397 (46.46/28.40)	PDLMNELLGDPGvlGGDTGNDLFNDLDLNF
  402-  429 (51.80/26.80)	PDIEEPVVGPQG..GDGSGQLMQQPLALGY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10727 with Med13 domain of Kingdom Metazoa
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