Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MKAQQQQQQQPPNAQLQASVSPRIKIVLGEKPSVTHCNPFYLMSKEPPQEAPLTGASNLIKHHDLEQAYSMYCTRRLREELSCFLPGLPGQIDTNGFEDGSSLSEMIERPPVTGKDLAPLSANAMSAFRLHEGPVPPELAQLFNKPPPQQQQQQQPQPPTPQSSQQSQQPPGRTRKRRHEAVITDLIGSSHNESNPGDNTSASSNTIVASQSTSASSSV |
Length | 219 |
Position | Head |
Organism | Macrostomum lignano |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.815 |
Instability index | 83.59 |
Isoelectric point | 6.59 |
Molecular weight | 23892.35 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10724 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 102.39| 22| 22| 134| 155| 2 --------------------------------------------------------------------------- 111- 133 (28.69/ 9.60) PVT.gKDLAPLSANAMSAFRLHEG 134- 155 (39.59/15.76) PVP..PELAQLFNKPPPQQQQQQQ 156- 179 (34.11/12.66) PQPptPQSSQQSQQPPGRTRKRRH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PFYLMSK 2) PRIKIVL 3) RRHEAVITDLIGSSH | 39 22 177 | 45 28 191 |
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