<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10721

Description Uncharacterized protein
SequenceQLQMSDSSRISAFPLPPMQYVNCYTDERVHSGTAPPPPRPLDSSYAMFGMPCTKEDAVIHSLESQGIRRLYPALYDHKRELKKLNFSILANYLDLMDIVVKCPDSQERLQKLEHMKTLFINVHHLINEYRPLQARDTLIEMLSLQSSVTHQSVDTASRYLARADAVVGRAAAASVGGDEDEPMRGADEAAGGEISQALLNDIDKLSAELSELTAAAAELDDAESAGFDLFASRGDDGNGDEAAGDSATDDVELEVDSDETSEDDDEADEAGEAVVNLPAGHQAAVGFSSTGNDAASGSLAQAPAAEAAVGAGKCLTTLQKVMVTMATIGLPSHPRRRRCRCHLLRTSPEEGATNASNCSSRHLRGLVRAALEADEANGGVGGSEVVARYLDARRQLLAAHSDAAEDSLKQLAASLLENVNSRLLSLGVQLPDEGNEADEPTVAATELFRLPDGVRLFFVASDGRIRHGGSNSSLSLFVFDDAATASEAEQSQSAQPPAFITVGSHWRCPLIPGVTPVLASASGALIFPDLEAQDEASSVGVMLPEGLDTESRFLLLDLLACLSRLGIERQPEAPEKPPPYAPTPTPAVTPADADADQKPARRHTSDHLVTGIGWTAARMCEGAVAGGRLAGDLLTRARLAAQKRMRPAAAGSSAGSAAGSSAGSAAGNSNESANLDHVTTGVRLLRQGSAVGVRVSRRLVSGLVSGAGFLASRVVYPHAVAPALNAVGVSTSGRGSRSRLAGAARVAGAALSGASDVWESLGAAGSQLATCAADNGQALATHRWGDRAGAVTGDALHAGGNVARIAWATNALGVRAALKVVAMETGKEAVGRMAESDGAKAASAASGSAPSTGAKR
Length856
PositionMiddle
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.04
Grand average of hydropathy-0.177
Instability index41.07
Isoelectric point5.12
Molecular weight88746.88
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10721
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     122.80|      25|      25|     720|     744|       1
---------------------------------------------------------------------------
  690-  725 (24.62/ 8.97)	AVGVRV....SRRLVSGLVSGA.gflasrvvyphaVA.PAL..N
  726-  752 (31.85/13.90)	AVGVST....SGRGSRSRLAGAA...........rVAgAAL..S
  754-  775 (22.71/ 7.67)	ASDVWE....SLGAAGSQLATCA..................adN
  793-  819 (21.81/ 7.05)	..GDAL....HAGGNVARIAWAT........nalgVR.AAL..K
  820-  853 (21.82/ 7.06)	VVAMETgkeaVGRMAESDGAKAA.......saasgSA.PST..G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      97.11|      23|      25|     264|     286|       2
---------------------------------------------------------------------------
  208-  231 (22.43/ 7.67)	ELSELTA..................aAAELDDAESAGFDLFA
  239-  279 (25.71/ 9.93)	GDEAA.GdsatddvelevdsdetsedDDEADEAGEAVVNLPA
  280-  304 (23.73/ 8.57)	GHQAAVG..............fsstgNDAA..SG.SLAQAPA
  393-  413 (25.25/ 9.62)	RRQ..LL...................AAHSDAAEDSLKQLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.07|      17|      24|     340|     363|       3
---------------------------------------------------------------------------
  332-  349 (27.23/15.58)	SHPRRRRCRcHLLRTSPE
  356-  372 (28.84/23.74)	SNCSSRHLR.GLVRAALE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.14|      24|      25|     608|     631|       4
---------------------------------------------------------------------------
  608-  631 (44.20/25.85)	LVTGIGWTAARMCEGAVAG...GRLAG
  633-  659 (36.93/20.19)	LLTRARLAAQKRMRPAAAGssaGSAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.11|       9|     112|     425|     434|       5
---------------------------------------------------------------------------
  425-  434 (13.67/11.95)	SLGVQLPdEG
  538-  546 (18.44/10.37)	SVGVMLP.EG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.93|      34|     540|      27|      69|       6
---------------------------------------------------------------------------
   27-   69 (53.91/51.91)	ERVHSGTAPPPPrpldssYAMFGMP.CTKEDAvihSLESQGIRR
  568-  602 (61.02/36.37)	ERQPEAPEKPPP......YAPTPTPaVTPADA...DADQKPARR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.45|      10|      25|      76|      85|       7
---------------------------------------------------------------------------
   76-   85 (17.03/13.56)	DHKRELKKLN
  104-  113 (16.41/12.79)	DSQERLQKLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10721 with Med7 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GFDLFASRGDDGNGDEAAGDSATDDVELEVDSDETSEDDDEADEAGEAVVNLPAGHQAAVGFSSTGNDAASGSLAQA
2) IERQPEAPEKPPPYAPTPTPAVTPADADADQKPARRHTSDHL
3) RMRPAAAGSSAGSAAGSSAGSAAGNSNESANLDHVT
226
567
644
302
608
679










Molecular Recognition Features






MoRF SequenceStartStop




1) KAASAAS
840
846