Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MKAQQQQQQQPPNAQLQASVSPRIKIVLGEKPSVTHCNPFYLMSKEPPQEAPLTGASNLIKHHDLEQAYSMYCTRRLREELSCFLPGLPGQIDTNGFEDGSSLSEMIERPPVTGKDLAPLSANAMSAFRLHEGPVPPELAQLFNKPPPQQQQQQQPQPPTPQSSQQSQQPPGRTRKRRHE |
Length | 180 |
Position | Head |
Organism | Macrostomum lignano |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.942 |
Instability index | 90.93 |
Isoelectric point | 8.49 |
Molecular weight | 20116.49 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10713 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 77.59| 21| 21| 117| 137| 2 --------------------------------------------------------------------------- 117- 137 (37.21/16.63) LAPLSANAMSAFRLHEGPVPP 139- 159 (40.38/18.68) LAQLFNKPPPQQQQQQQPQPP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FYLMS 2) GRTRKRRH 3) LAQLFNK 4) PRIKIVL | 40 172 139 22 | 44 179 145 28 |
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