<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10711

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMLSVLEDIELLSKALFEALATREQCSTSDRSASGQQQQQQQPLELNCEALVEQLRLREAKLHRLRDQAAKQQQLHEKANQLRALIDQQDLAIGQHQRQLMEADRLLSVAIFYSRQKLESLQTACQNPADSEELVKFAHKISASNGVMAPLGWGLGDPRRPYPTANEMARGLLKHVDEHGNFQPGIVEEVASLSAAAAAAAAAAAAGRQQQQQQQQQQQQQQQYPQQMSASSAASSTAQAQPTAGASAEQVETMSSDSSSSSSSGD
Length265
PositionMiddle
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.03
Grand average of hydropathy-0.630
Instability index61.66
Isoelectric point5.30
Molecular weight28772.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP10711
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.15|      10|     170|      32|      41|       1
---------------------------------------------------------------------------
   32-   41 (20.84/ 6.58)	ASGQQQQQQQ
  213-  222 (20.31/ 6.26)	QQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.05|      16|      33|       8|      23|       2
---------------------------------------------------------------------------
    8-   23 (25.64/17.42)	IELLSKALFEALATRE
   43-   58 (27.41/19.06)	LELNCEALVEQLRLRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.74|      21|      24|      70|      90|       4
---------------------------------------------------------------------------
   70-   90 (35.53/19.43)	KQQQLHEKANQLRALI..DQQDL
   95-  117 (28.21/14.11)	HQRQLMEADRLLSVAIfySRQKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10711 with Med4 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAGRQQQQQQQQQQQQQQQYPQQMSASSAASSTAQAQPTAGASAEQVETMSSDSSSSSSSGD
2) GWGLGDPRRPYPTANEMARGLLKHVDEHGN
200
151
265
180










Molecular Recognition Features






MoRF SequenceStartStop




1) QYPQQMSA
2) STAQAQPTAGASAEQVETM
222
235
229
253