<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10707

Description Uncharacterized protein
SequenceMSMPSFPSLETLSLKKARLERKPLGPPEVYPQMPNQDEDKLDQVNVREGFKDILQNRFKGTKLEEYSSIAKNFNCSSEDVLGAFKKIVQRKVDVNVMPDTSKRRGAISKDISLPMAGRTASKVEEWFKDFKSGEQLTKLSAKVPLSVKKEDILKEVFKNRLPVHRAIWYLKVWWQFSSSLSESSKKKKPFDAPEVQVKNDICTHLKDTFEAAVDGADEDVQDEWNYVWDLLVAMLDQSLFEQLEILRWVTEFVERCRRSENQLAFLLPHLLAVVQHFSTSELESRRFLGVCCSVVHDLSSVVDLQFAQRSQCPQHYQILLSVTSLIVTTILRCPESAVWSAAVSCESPLYGSPLDRLPCNLLCLPVPPKLLDPLRQLMLEIINRSAEAEQHWTRRVDSPDTLRLIEVLEHLDKHDYMSEDNKEALQQGESEMPLQDKDIMHNLFTKCFDREDPESDLRVANLLCQWAVHPSRGGCHRPVVAAVLMEKLRLLNRVDPVRLHDQLVSFLNSDSAPRQDRESGPDCQEPFRNLVALFGELIDREIFDHDSYARYLIAHDILSSEKAPLVFSETEYSPPGLAQQPSKHIQYLAHFPLPADDTYAHEASQRLHMLYGVGKSEEALKRFLRRLVREVSRLFTKKHNLMDASTGMYAKQRRAGSADEDAELNDIRRRFSMLTFCEMELVTAQGKRSLMESLRQFYEDPSCNILPSPSRMLFLMNLVELSGNLTGLIYFLVEISNSILKVENKVCPGSAAAAGAAMPVTPEEQQRNNFLRMWSNKVVLRVLGYLRQYQAILMTMPAEMRALFSNLVRTNVKKVGNPEQCSCADRCTLAYLFDLYSQSISVKAGFHNIFSRARPKLKQAIYKKIEAYEIPQAKFPPTLMNLTHPSIEELLLNDEEERKRANSSEEEKRTNFFSYYLYNVLMCDTDEKVLKTCVEACECTTFCAQLPPRWLWILRALLNSASGSAKFEPVLPQMLRDLVCNCPNLAEKLSVLCGLLLSRTCFTIADFNQSAEPSARLAIHVFYLIVTLKLPLKSLTDKLLLRGAVVDKISSNSLSFFLKVLLLIPGDSWLECVQREAARESPVDLRSLRFADFAARVYKEITDSAWIREKFLRQPFTETLLSKEALLDSFITDSQARFILHSIAYRCPTPQRAEMTGSSVASFSDFWRQTQNFSHLFKGLSLWYLTWSLLEVELSLLRLISGPGDLDSTQRQFANSLCEFFSHRVAPVLKSETAATPTPSGGSQAYQLQHHQQLHQPPPPPGLPLIEPVETDWLVSLLIRKLSSHSLGPSIRAQIVKSAGSLLDCGASFSNAKADHEREDMLRRSSVLLAYPPFLCLLQESLAEESVRLDILSPGTQSGLFQQINRYIEHAEKALDSGIEEDLRVRCLLGQALRLRLSLVGSLFGVLLQNTSLCAEWSMLLAKLVTHSVVDIGSSREDFHRVIDMLVSLLHAVATGPPGSDPERQPTLDDERKNLLGVVKKLRKELKDSDLLPAPLRPLFVTPRLTFEVPVCRIARRPASCILHGREHMSPLELIEGVKTFQPLSLSWYTAMRYDLPPSRHELAHLVAPLTRAGPGARPVRDERYYLRSPDLPEEDLVPDEPKKMKMSNGLPAVPHQQMQHPQHPMHSQHQHPGQIPYHMMTPQQQHHHHHHHMHQQQLQHQHAHQHAQMQHQHTHQPPHPPHQQQHQPHQPLHQQLHQNPHQNLHSQHSHQPPPLPPPAPQTTGRKSVKKKASLQQQQQQQ
Length1742
PositionKinase
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.362
Instability index57.33
Isoelectric point7.19
Molecular weight198466.60
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10707
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     291.99|      87|     100|     346|     444|       1
---------------------------------------------------------------------------
  346-  440 (126.25/94.00)	ESPlyGSPLdRLpCNLLC.LPVPPKLLDPLRQLMLEIINRSAEAEQHWTRRVDsPdtLRLIEVLeHLDKHD....YMSEDN....KEAL.QQG.ESEMP..........LQDKDIM
  451-  543 (105.97/59.38)	EDP..ESDL.RV.ANLLCqWAVHPSRGGCHRPVVAAVLME....KLRLLNRVD.P..VRL.........HDqlvsFLNSDS..apRQDR.ESGpDCQEPfrnlvalfgeLIDREIF
  606-  666 (59.76/27.31)	..............................RLHMLYGVGKSEEALKRFLRRL.....VREVSRL.FTKKHN....LMDASTgmyaKQRRaGSA.DEDAE..........LND....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     119.12|      20|      20|    1661|    1680|       2
---------------------------------------------------------------------------
 1244- 1261 (24.14/ 7.60)	..QAYQLQhHQQLHQPPP..PP.
 1664- 1685 (42.00/18.94)	AHQHAQMQ.HQHTHQPPHppHQQ
 1686- 1701 (25.74/ 8.61)	QHQPHQPL.HQQLHQNP......
 1702- 1719 (27.24/ 9.56)	.HQ..NLH.SQHSHQPPP.lPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.05|      28|      85|    1028|    1058|       5
---------------------------------------------------------------------------
 1028- 1058 (40.20/38.82)	LKLPlksLTDKLLLRGAVVDK.ISSNSLSFFL
 1112- 1140 (41.85/30.88)	LRQP...FTETLLSKEALLDSfITDSQARFIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.01|      19|      20|    1612|    1630|       8
---------------------------------------------------------------------------
 1590- 1609 (25.81/11.43)	PD.......LPEEDL.VPDEPkkMKMSN
 1612- 1630 (40.47/22.70)	PA.......VPHQQMQHPQHP..MHSQH
 1633- 1658 (33.74/17.52)	PGqipyhmmTPQQQHHHHHHH..MHQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.18|      16|      18|     965|     980|      12
---------------------------------------------------------------------------
  944-  959 (27.34/15.34)	AQLPPRWLWILRALLN
  965-  980 (27.88/15.80)	AKFEPVLPQMLRDLVC
  986- 1001 (23.96/12.38)	AEKLSVLCGLLLSRTC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10707 with Med12 domain of Kingdom Metazoa
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