<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10706

Description Uncharacterized protein
SequenceMSMPSFPSLETLSLKKARLERKPLGPPEVYPQMPNQDEDKLDQVNVREGFKDILQNRFKGTKLEEYSSIAKNFNCSSEDVLGAFKKIVQRKVDVNVMPDTSKRRGAISKDISLPMAGRTASKVEEWFKDFKSGEQLTKLSAKVPLSVKKEDILKEVFKNRLPVHRAIWYLKVWWQFSSSLSESSKKKKPFDAPEVQVKNDICTHLKDTFEAAVDGADEDVQDEWNYVWDLLVAMLDQSLFEQLEILRWVTEFVERCRRSENQLAFLLPHLLAVVQHFSTSELESRRFLGVCCSVVHDLSSVVDLQFAQRSQCPQHYQILLSVTSLIVTTILRCPESAVWSAAVSCESPLYGSPLDRLPCNLLCLPVPPKLLDPLRQLMLEIINRSAEAEQHWTRRVDSPDTLRLIEVLEHLDKHDYMSEDNKEALQQGESEMPLQDKDIMHNLFTKCFDREDPESDLRVANLLCQWAVHPSRGGCHRPVVAAVLMEKLRLLNRVDPVRLHDQLVSFLNSDSAPRQDRESGPDCQEPFRNLVALFGELIDREIFDHDSYARYLIAHDILSSEKAPLVFSETEYSPPGLAQQPSKHIQYLAHFPLPADDTYAHEASQRLHMLYGVGKSEEALKRFLRRLVREVSRLFTKKHNLMDASTGMYAKQRRAGSADEDAELNDIRRRFSMLTFCEMELVTAQGKRSLMESLRQFYEDPSCNILPSPSRMLFLMNLVELSGNLTGLIYFLVEISNSILKVENKICPGSAAAAGAAMPVTPEEQQRNNFLRMWSNKVVLRVLGYLRQYQAILMTMPAEMRALFSNLVRTNVKKVGNPEQCSCADRCTLAYLFDLYSQSISVKAGFHNIFSRARPKLKQAIYKKIEAYEIPQAKFPPTLMNLTHPSIEELLLNDEEERKRANSSEEEKRTNFFSYYLYNVLMCDTDEKVLKTCVEACECTTFCAQLPPRWLWILRALLNSASGSAKFEPVLPQMLRDLVCNCPNLAEKLSVLCGLLLSRTCFTIADFVTNVLFPVVSDYLKNQSAEPSARLAIHVFYLIVTLKLPLKSLTDKLLLRGAVVDKISSNSLSFFLKVLLLIPGDSWLECVQREAARESPVDLRSLRFADFAARVYKEITDSAWIREKFLRQPFTETLLSKEALLDSFITDSQARFILHSIAYRCPTPQRAEMTGSSVASFSDFWRQTQNFSHLFKGLSLWYLTWSLLEVELSLLRLISGPGDLDSTQRQFANSLCEFFSHRVAPVLKSETAATPTPSGGSQAYQLQHHQQLHQPPPPPGLPLIEPVETDWLVSLLIRKLSSHSLGPSIRAQIVKFAGSLLDCGASFSNAKADHEREDMLRRSSVLLAYPPFLCLLQESLAEESVRLDILSPGTQSGLFQQINRYIEHAEKALDSGIEEDLRVRCLLGQALRLRLSLVGSLFGVLLQNTSLCAEWSMLLAKLVTHSVVDIGSSREDFHRVIDMLVSLLHAVATGPPGSDPERQPTLDDERKNLLGVVKKLRKELKDSDLLPAPLRPLFVTPRLTFEVPVCRIARRPASCILHGREHMSPLELIEGVKTFQPLSLSWYTAMRYDLPPSRHELAHLVAPLTRAGPGARPVRDERYYLRSPDLPEEDLVPDEPKKMKMSNGLPAVPHQQMQHPQHPMHSQHQHPGQIPYHMMTPQQQHHHHHHHMHQQQLQHQHAHQHAQMQHQHTHQPPHPPHQQQHQPHQPLHQQLHQNPHQNLHSQHSHQPPPLPPPAPQTTGRKS
Length1742
PositionKinase
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.337
Instability index56.53
Isoelectric point6.98
Molecular weight198464.70
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     135.63|      20|      20|    1675|    1694|       1
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 1627- 1637 (21.30/ 7.64)	AVPHQQMQ...............HPQ
 1638- 1653 (22.31/ 8.43)	HPMHS..QHQHPGQiPYH........
 1657- 1677 (22.96/ 8.93)	....PQQQHHHHHH.HMHqqqlqHQH
 1678- 1699 (42.78/24.31)	AHQHAQMQHQHTHQ.PPH...ppHQQ
 1700- 1715 (26.27/11.50)	QHQPHQPLHQQLHQ.NP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     371.34|      95|     100|     352|     451|       2
---------------------------------------------------------------------------
  352-  451 (162.06/107.18)	SPLDRLPCNLLC.LPVPPKL.LDPLRQL.......................MLEIINRSAEAEQHWTRRVDSPDTLRLIEvlehlDKHD....YMSEDN..KEAL..QQ...G.ESEMPLQDKDIMH..NLFTKCFDRE
  455-  541 (112.17/64.99)	SDL.RV.ANLLCqWAVHPSR.GGCHRPV.......................VAAVLME....KLRLLNRVD.P..VRL.........HDqlvsFLNSDSapRQDR..ES...GpDCQEPFRN...LV..ALFGELIDRE
  563-  677 (97.11/55.15)	APLVFSETEY.....SPPGLaQQPSKHIqylahfplpaddtyaheasqrlhMLYGVGKSEEALKRFLRRL.VREVSRLFT.....KKHN....LM..DA..STGMyaKQrraG.SADEDAELNDIRRrfSMLTFC....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.05|      28|      80|    1042|    1072|       3
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 1042- 1072 (40.20/30.80)	LKLPlksLTDKLLLRGAVVDK.ISSNSLSFFL
 1126- 1154 (41.85/24.44)	LRQP...FTETLLSKEALLDSfITDSQARFIL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     228.74|     112|     407|     747|    1034|       4
---------------------------------------------------------------------------
  706-  739 (18.51/83.95)	LPSPSRMLFlMNLVELSGNLTG............LIYFLVEISNSI...................................................................................................................................................................................................................
  796-  840 (13.37/275.19)	MPAEMRALF.SNLVRTNVKKVGnpeqcscadrctLAYLFDLYSQSI...................................................................................................................................................................................................................
  947- 1034 (101.58/ 7.71)	..............................................svkagfhnifsrarpklkqaiykkieayeipqakfpptlmnlthpsieelllndeeerkransseeekrtnffsyylynvlmcdtdekvlktcveacecttfcaqlPPrWLWILRALLnsASGSAKFEPVLP.......QMLRDLV.....CNCPNLAEKLSVLCglLLSRTCFTIADFVTNvLFPVVsdyLKNQS..AEPS...ARLAIH
 1346- 1441 (95.28/ 0.00)	........................................................................................................................................................PP.FLCLLQESL..AEESVRLDILSPgtqsglfQQINRYIehaekALDSGIEEDLRVRC..LLGQALRLRLSLVGS.LFGVL...LQNTSlcAEWSmllAKLVTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     225.78|      75|      85|    1155|    1236|       6
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  168-  202 (37.20/17.57)	WYLkVWWQFSSSLSESSKKKKP..FDAPEVQVKNDI..C..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1155- 1196 (35.98/36.35)	............................................thlkdtfeaavdgadedvqdewnyvwdllvamldqslfeqleilrwvtefvercrrsenqlafllphllavvqhfstselesrrflgvccsvvhdlssvvdlqfaqrsqcpqhyqillsvtslivttilrcpesavwsaavscesplygspldrlpcnllclpvppklldplrqlmleiinrsaeaeqhwtrrvdspdtlrlievlehldkhdymsednkealqqgesemplqdkdimhnlftkcfdredpesdlrvanllcqwavhpsrggchrpvvaavlmeklrllnrvdpvrlhdqlvsflnsdsaprqdresgpdcqepfrnlvalfgelidreifdhdsyaryliahdilssekaplvfseteysppglaqqpskhiqylahfplpaddtyaheasqrlhmlygvgkseealkrflrrlvrevsrlftkkhnlmdastgmyakqrragsadedaelndirrrfsmltfcemelvtaqgkrslmeslrqfyedpscnilpspsrmlflmnlvelsgnltgliyflveisnsilkvenkicpgsaaaagaampvtpeeqqrnnflrmwsnkvvlrvlgylrqyqailmtmpaemralfsnlvrtnvkkvgnpeqcscadrctlaylfdlysqsisvkagfhnifsrarpklkqaiykkieayeipqakfpptlmnlthpsieelllndeeerkransseeekrtnffsyylynvlmcdtdekvlktcveacecttfcaqlpprwlwilrallnsasgsakfepvlpqmlrdlvcncpnlaeklsvlcglllsrtcftiadfvtnvlfpvvsdylknqsaepsarlaihvfylivtlklplksltdklllrgavvdkissnslsfflkvlllipgdswlecvqreaarespvdlrslrfadfaarvykeitdsawirekflrqpftetllskealldsfitdsqarfilHSIA..YRCPTPQRAEMTGSSVAsFsdfwrQTQNFSHLFK.....GLSL
 1197- 1279 (120.47/88.25)	WYL.TWSLLEVELSLLRLISGPGdLDSTQRQFANSL..C.EFFS........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HRVApvLKSETAATPTPSGGSQA.Y.....QLQHHQQLHQpppppGLPL
 1287- 1324 (32.13/13.68)	WLV...SLLIRKLSSHSL..GPS.IRAQIVKFAGSLldCgASFS.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.88|      13|     407|     333|     348|       7
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  333-  348 (21.01/22.72)	CPESAvwsAAVSCESP
  747-  759 (25.87/15.97)	CPGSA...AAAGAAMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.36|      16|     407|    1084|    1104|       8
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 1084- 1099 (27.06/11.57)	LECVQREAARE...........SPVDL
 1522- 1548 (19.30/ 7.70)	EVPVCRIARRPascilhgrehmSPLEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.82|      17|      19|    1589|    1607|      10
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 1589- 1607 (27.71/17.85)	PGARPvrDERYYLR.SPDLP
 1609- 1626 (25.11/10.40)	EDLVP..DEPKKMKmSNGLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10706 with Med12 domain of Kingdom Metazoa
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