<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10701

Description Uncharacterized protein
SequenceEGVEQKLEELVTHEYQLVAGNKKRWRWLPRTTVKSASHFLPGKWSRLKVSKRIMTAYLGGNGRHFCDELLAFAPSRHETIAQYDQAVVYASVGPAPAADDEADDYLLSGIIRHLRPQSPGLLRSRAGGRTGSRSTRRRLSAHRRPTCWTIRAPLPGPTARCTFFDANSWTYGNPQPDQRLPESTNDGEGVQNDAASADSGRPAADAPQVIVEMISDDENVPTSVANATGELTISDSVRAASLSTSAAVSDSDSSETGSSDGEERDRDGGEDAAADADGSDSDSCVIVGYERPWEERTPISLSSESRPPPMRKTPLTRQTPASGSSPSVGASWLRRALLSEMLSIEGDGQTAGPSSSGFGDFVEDNQPTDGNASTRPKPSTSGFVRRRRRRQWEPPSPPREDSDNSADSDVVVVSVGWATPPPVGLSGGLSPAATAAATAADFRRRARQFENRCRQLRRRDHRRALRRRRQAEMLSSASSSAATSSASDIVSNAATAGDSSVAAEPAESALVLDDGSLLLSDILETAAMAAAQEYRERNLVKAVYCLKRKFKFSFQSVRFPGFLCKYFSDKIFKAVRMNSQRQQQAKPAVPASSSSSCSSSQQPQQQQAGKQPRGPGWTRIFVASCPPNASESKTPFEFEGRKVGRGSYGQVFKTKPRGCADASAGDYALKQIEGSGLSMSACREIALLRELKHPNVISLKQVYLAHETRQIWLLAKKCNSQVSLPPNFTKSIMHQILCGIHYLHSNWAGQHPGNGCHLAGARRVKIADLGLARLFHQPLTPLTEIDPVVVTFWYRAPELLLGARHYTKAIDLWAIGCIMAELITDKPLFYCKQEEDIKTSSPYNRDQLERIFSDWRDLPHLPKYGDLVRNFGTGQQYARFSLGRHMSRSFGMSETSSEFRLLSRLLAMDPLRRPSAREALEDRWEPRCRPLTSFNDFDIPVRQADFISDSSDNKDDPARLHFASRGRHLAVASAQQTAETHLLAAAAASLRLWGELRQFWQISLQQQFGNSGSKL
Length1015
PositionKinase
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.07
Grand average of hydropathy-0.562
Instability index60.32
Isoelectric point9.11
Molecular weight111648.69
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10701
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.20|      18|      29|     603|     621|       1
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  603-  621 (30.83/18.96)	PQQQQAGKQPRGpGWTRIF
  635-  652 (33.37/15.88)	PFEFEGRKVGRG.SYGQVF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     455.92|     132|     301|      94|     239|       2
---------------------------------------------------------------------------
   94-  229 (224.42/105.88)	PAPAADDEADDYLLSGIIRHLRPQSPgllRSRAGGRTGSRSTRRRLSAHRRPTCWTIRAPLPGPT.ARCTFFDANSWTYGNPQPDQRLPESTNDGE.GV.QNDAAS..ADSGRPAADAPQVIvEMISDDENVPTSVANATG
  270-  376 (149.73/65.78)	EDAAADADGSDSDSCVIVGYERPWEE...RTPISLSSESRPPPMRKTPLTRQTPASGSSPSVGASwLRRALLSEMLSIEGDGQTAG..PSSSGFGD.FV.EDNQPTdgNASTRP...........................
  910-  978 (81.77/29.98)	...........................................................PLRRPS.AREALED..RW.....EPRCRPLTSFNDFDiPVrQADFIS...DSS.DNKDDPARL.HFASRGRHLAVASAQQTA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.82|      22|     260|     232|     254|       6
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  232-  254 (31.66/18.13)	TISDSVRAASLSTSAAVSDsDSS
  495-  516 (36.16/17.30)	TAGDSSVAAEPAESALVLD.DGS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.22|      28|     708|      41|      69|       9
---------------------------------------------------------------------------
   41-   69 (48.83/37.77)	PGKWSRLKVSKRIMTAYLgGNGRHFCDEL
  752-  779 (51.39/34.43)	PGNGCHLAGARRVKIADL.GLARLFHQPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10701 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSEMLSIEGDGQTAGPSSSGFGDFVEDNQPTDGNASTRPKPSTSGFVRRRRRRQWEPPSPPREDSDNSADSDVVVVSVGW
2) QFENRCRQLRRRDHRRALRRRRQAEMLSSAS
3) QQQAKPAVPASSSSSCSSSQQPQQQQAGKQPR
4) TYGNPQPDQRLPESTNDGEGVQNDAASADSGRPAADAPQVIVEMISDDENVPTSVANATGELTISDSVRAASLSTSAAVSDSDSSETGSSDGEERDRDGGEDAAADADGSDSDSCVIVGYERPWEERTPISLSSESRPPPMRKTPLTRQTPASGSSPSVGASW
338
448
582
170
417
478
613
332










Molecular Recognition Features






MoRF SequenceStartStop




1) GYERPWEERT
2) VGASWLRRALLSEMLSIE
3) WTRIFV
288
328
617
297
345
622