<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10700

Description Mediator of RNA polymerase II transcription subunit 13
SequenceTSRPATSACATATPDRAPRRAFTCPACWTGGLRLAVPASQPAPTGPLASASPTSSMRICATLLGDRRRLDYRPWPSTYSPAVIDSLLNFVSLSPFRSRQFRSPPQLSSKQSQSDATNSAVAVVAGAAAAAGAATADPAASSSLHPGHLAQFEDCNEAAKLVLQDCISRSSSSSHFHWLNSQPCAPLNCHRMRSLNWPAAHGWLGFGPIIKKASDPGSKDSLWGKALQGNYWVTGPMTWQEFHQCRSECCLSTDGVARCAAFGPLKDRESCQRELGMTGPVSLFAPPYVLHASSDETGAITSGGELNYRRLINLRVPDCHRRRKASTRQLGPERLLEWICDLPETRAQRWRLVLSRLGRLGHGELLVWADLLKTGQPAAARRPLGPLCAQSTPIPICASCPTSSVGKVRNAVRPASAPTGVSAAQSRTSLCCQLRPVFSQANPADFLGGSLGEPDLMNELLGDPGVLGGDTGNDLSRLLGRRAATGSGQLMQQPLALGYYLSSAPPGPVPAWFRVAPPEQAAVCLRASLHLNQLASCDRAPLSAACDRSPTHPLNTYKTTEVLRYVLLETCHSLSWLSVDPATGDRVSCLPRHINQLFLLLPFCARHV
Length607
PositionMiddle
OrganismMacrostomum lignano
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Rhabditophora> Macrostomorpha> Macrostomida> Macrostomidae> Macrostomum.
Aromaticity0.06
Grand average of hydropathy-0.192
Instability index60.19
Isoelectric point9.16
Molecular weight65063.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10700
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     339.76|      95|     120|     329|     426|       1
---------------------------------------------------------------------------
    3-   51 (38.85/10.33)	.........................................................RPATSACA..TATPdrAPRRAfTCPACWTGGLRLAV.PASqpAPTGPLASAS.
  329-  426 (164.07/76.27)	LG.PERLLEWICDlPETRAQRWRLVLSR.LGR...LGHGELLvwADLLKTGQPAAARRPLGPLCA..QSTP..IPICA.SCPTSSVGKVRNAVRPAS..APTGVSAAQSR
  450-  547 (136.84/56.25)	LGePDLMNELLGD.PGVLGGDTGNDLSRlLGRraaTGSGQLM..QQPLALGYYLSSAPP.GPVPAwfRVAP..PEQAA.VCLRASL.HLNQLASCDR..AP..LSAACDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.74|      17|      25|     234|     254|       3
---------------------------------------------------------------------------
  234-  254 (23.67/26.03)	GPMtwQEFHQCRSEccLSTDG
  262-  278 (32.07/16.55)	GPL..KDRESCQRE..LGMTG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10700 with Med13 domain of Kingdom Metazoa
Unable to open file!