<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10691

Description Uncharacterized protein
SequenceMESGINENMNNILEYEEGHKPSSNNTDHIVVEMENRTRFETTSRSKATGGHPPLPDVPDSFESPSIPLGTLMKYGVYKISQELTILSDLVPKSTDQNKKISIVEFSYLARQITVKILALVKWVKQFKKYRVCIPITYFLEQQAQLFIETADTLVRIAREELLYARVAYYEIPAAIDIQHGVFTRMPLCIKKRFIPEPPVTPQQEAECLSRLSYIIQAKIAFSSNKLSPRIKNIDIKNGHVTLTVPGEFAVCLTLLGEEKDTKWTLLNISILVEQYEIGYGTKLVHPLQLHTMHNLIQNRIHHSEEPIVELYTILHYFCVGLQLDVLFCEATQLITNQLKGCINIENYDNTLGSLTISYWPVFDGKRFTSSQFKFTVYRDDNSNNSGLRVKHFPLGDNLPGLDENNGKLSLSNLISETVKVRAFEKSLRIKKKLDSMKPYIIVEVVGVMSPKLIYPLLIMGTRGEEECLHISISMFSGNVVCNVPYLGDYQMLDKLSAAFNKNASVANLSKMIEKIRTSLLLKRYSSAIADLNIRLLKKGEVKQNIINNVLFKDKECLFFNLPKEKAFSIGIVFTPDSRTGVNIHFFLISFNSNKSTFMQLEPSKLIYSGTEINLVDSEDMVISNYENIRRAHEQVWIGCERQLKAAVAVIEEKISFIKICEQLDMKKIKYTQIARQSFVGGLYIEIKEFNKYHATQSSTFYENLRHCYLRVDSRAKVVWPLEFTVINTPVVSDYFTKPPFGDEAVATTGAKTCFQDIYESSIASQSYLSTSEAITSAVIERLDTFSKLYNPIERFAQAYYKYYHNHCNIVLYSYHKLIIAYGEKRDMLLFLTYKSKNKMFLLSFGQCLPRDTLNQVGPKRTNSKDDYTIWNPHSIVKEFLNEKLTTGHSLTPIIQYVVNTIRPLKSLIKFAYPKIRSIGAFSQTMKIDSTYPAELRCFLATQDDNIIRLSYGIIQLEFCFVSNGDVFIRDCSRSAPLSVGLGAFLDLMCPGASVVNLNTADNEYFSPRSLPVNSSNTSSPAKSNARLSLSVPAPKNNSADGMDISQNESADFFSMTIESRQLHYSTNRNVFKINQDSMEKMCLDTNVNSNFSYLDDYLYGINYLEKIGAILDFQKRDITLGGSNPSFVINNLSISMYHINATLFGIRHPNKENGWNINIHVYLDPKLFKVKCKLEFNGNSIPLVDDIETAEKYFEKCVVRSGNESSILSFINMCRICNSRAFANLAYLMKLEMNPNPDHFYKFFFQLAPTKIEQLPNSSMAIRPWKINPTDSSIDNSKIDINCIYAFTPNVLTLRPTGQTHDPREQVILDIFKRESEAAKAAGECCIARCINSILIAEKKSTL
Length1343
PositionTail
OrganismRhabditophanes sp. KR3021
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Alloionematidae> Rhabditophanes> unclassified Rhabditophanes.
Aromaticity0.10
Grand average of hydropathy-0.177
Instability index41.22
Isoelectric point8.38
Molecular weight152812.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10691
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.30|      29|     562|     527|     616|       1
---------------------------------------------------------------------------
  581-  616 (36.07/106.09)	VNIHFFLisfnsNKSTFmQLEpSKLIYSGTEINLVD
 1157- 1185 (53.23/11.29)	INIHVYL.....DPKLF.KVK.CKLEFNGNSIPLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     424.12|     195|     562|      95|     317|       2
---------------------------------------------------------------------------
   95-  231 (150.04/168.31)	.................................................................................................................................................................................................................................................................................................................................................................................................................................................DQNKkisiVEFSYLARQITVKILALvkWVKQFKKYRVCIPITYFLE.QQAQLFIETADTLVRIAREELLYARV..AYYEIPAAIDiQHGVFTRMPLCIKKrfIPEPPVTPQ...QEAECLSrlSYIIQAKIAFSsnKL.SP..RIK
  232-  317 (52.18/73.08)	NIDIKNGHVTLTVPGEFAVCLTLLGEEKDTKWTLLnisilveqyeiGYGTKLvhPLQlhTMHNLIQNRIHHSEE.PIVELYTILHYF............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  664-  796 (155.88/125.62)	.......................................................................................cvglqldvlfceatqlitnqlkgcinienydntlgsltisywpvfdgkrftssqfkftvyrddnsnnsglrvkhfplgdnlpgldenngklslsnlisetvkvrafekslrikkkldsmkpyiivevvgvmspkliypllimgtrgeeeclhisismfsgnvvcnvpylgdyqmldklsaafnknasvanlskmiekirtslllkryssaiadlnirllkkgevkqniinnvlfkdkeclffnlpkekafsigivftpdsrtgvnihfflisfnsnkstfmqlepskliysgteinlvdsedmvisnyenirraheqvwigcerqlkaavavieekisfikiceqlDMKK....IKYTQIARQSFVGGLYI..EIKEFNKYHATQSSTFYENlRHCYLRVDSRAKVVWPLEFTVINTPVvsDYFTKPPFGD.EAVATTGAKTCFQD..IYESSIASQsylSTSEAIT..SAVIERLDTFS..KLyNPieRFA
  808-  879 (66.01/44.59)	NIVLYSYHKLIIAYGEKRDMLLFLTYKSKNKMFLL...........SFGQCL..PRD..TLNQVGPKRTNSKDDyTIWNPHSIVKEF............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.20|      12|     581|     478|     489|       3
---------------------------------------------------------------------------
  478-  489 (25.77/15.32)	NVVCNVPYLGDY
 1086- 1097 (24.43/14.11)	NVNSNFSYLDDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.89|      21|     126|    1186|    1208|       6
---------------------------------------------------------------------------
  996- 1019 (28.20/12.53)	NLNTADnEYFspRSLPVNSSNTSS
 1186- 1206 (37.69/27.79)	DIETAE.KYF..EKCVVRSGNESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.14|      32|     834|      46|      79|      11
---------------------------------------------------------------------------
   46-   79 (52.07/34.75)	KATGGHPPLPdVPDsFESPSI.PLGTLMKYGVYKI
  883-  915 (52.06/26.78)	KLTTGHSLTP.IIQ.YVVNTIrPLKSLIKFAYPKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10691 with Med14 domain of Kingdom Metazoa
Unable to open file!