<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10679

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGVDIVIATPGRLIDTLENAIISLTHCTYLILDEADRMLDEGFEPEILKILEYMPESNMKPDTEDAEDEIKLMANFATKEKYRQTVMFTATMSPAIERLARKYLRRPATVSVGSINRPTERVEQIVYMLSEEQKHKKMVEVLEKFTTYPIIIFVNTQKGADLISKSLIKQGHSVAVLHGGKGQDAREHSLSSLRDKTKDILVATDVAGRGIDIKNVSLVLNYDMPKNIEAYTHRIGRTGMSAANVEDEDWPSQKFREHVILRLEPELARNRQQAPNLPVPGNAREVEDYVFQKCTSKDEYMRTIAKVINAINCNSKTSSVPSAINSSFNKNGMSPTTGINPPSNIPPDPQPTQQNDTSNLTMSSGAIGGNLNNMTINQQQNSNMIPNDSRLAHVTPMVQNKMAMGGGVSGMGGMANQMGSNQMSGYNNGPIPNSSPINNQQNFIQSGQASNRFPNRPINGPPNFDNNICDMNPFGQGSSPNMSGVGPLNGPNMYNQQVDGNKGVMVNEMMGNNGGINPNKRPLYNQQEQQFMGNGGMMRTHSGNMGMMSNQQGYNNYNNYQGGNNQMMENNMMYQNSHIPDITDDDRRMRLEALKQHVNMLKGRSTFFKNSGENSQAQKLDFMIEAIINVKPIGNDILVKIENEVSKSLYNVPLQQQSGPIAPKIENIPMVRPQMNNQEFGVHNQWMPQNQMNSPMQQPNYHPHGPPNQLPQGGHNPYVVPGSPSTSQNVRHSPYPLPPKNHFGNYNRPQNIGQQQQPQNQFNNYGYNGPQLSGSMPTSSTFDDGFNNFDPFMGMNDGTMTSNNSNSSSVQNMYVQSPVFSNGPNFMGNLLNPQMAKEINLFKGTFNFPKISPTPDGNSIHIEAAFSSNNGFPNLRLIVPKNYPLAPATLEKGEFALEDFYYDELNTSVHDEVARLNARTISDILNASENVVKSFFQNQEMNPLNNLGTPSIDEIFNTSFNPSL
Length964
PositionTail
OrganismRhabditophanes sp. KR3021
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Alloionematidae> Rhabditophanes> unclassified Rhabditophanes.
Aromaticity0.07
Grand average of hydropathy-0.681
Instability index50.11
Isoelectric point5.93
Molecular weight107161.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
helicase activity	GO:0004386	IEA:UniProtKB-KW
hydrolase activity	GO:0016787	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10679
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.98|      26|      27|     447|     472|       1
---------------------------------------------------------------------------
  455-  480 (44.51/13.73)	NRP..INGPPNFDN...NICDMNpfG.QGSS....P
  700-  721 (31.34/ 7.60)	NYH..PHGPP.......NQLPQG..G.H..NPYvvP
  747-  777 (29.14/ 6.58)	NRPqnIGQQQQPQNqfnNYGY.N..GpQLSGSM..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.38|      11|      23|      12|      22|       2
---------------------------------------------------------------------------
   12-   22 (17.71/10.85)	RLID.TLENAII
   37-   48 (15.68/ 8.76)	RMLDeGFEPEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     464.68|      85|     168|     318|     402|       3
---------------------------------------------------------------------------
  225-  295 (80.78/33.35)	...PKNIEAYTHRIG...RTGMS.AANVED...EDWPSQKfREHVI......LRLEP..............ELARNRQQ..APNLpVPGNAR..EVEDYVfQKCT
  318-  401 (142.69/65.24)	SSVPSAINSSFNKNGMSPTTGINPPSNIPP...DPQPTQQ.NDTSN......LTMSSG..AI....GGNLNNMTINQQQ..NSNM.IPNDSRLAHVTPMV.QNK.
  402-  441 (32.83/ 8.65)	....................................................MAMGGGvsGM....GGMANQMGSNQMSgyNNGP.IPNSS......P.I.NNQQ
  506-  573 (100.56/43.54)	......VNEMMGNNG.....GIN.PNKRPL...YNQQEQQ.............FMGNG..GMmrthSGNMGMMS.NQQG..YNNY...NNYQGGNNQMME.NNMM
  605-  692 (107.81/47.27)	STFFK..NSGENSQAQKLDFMIEAIINVKPignDILVKIE.NEVSKslynvpLQQQSG..PI....APKIENIPMVRPQ.......MNNQEFGVHNQWMP.QNQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.47|      28|      33|     898|     930|       4
---------------------------------------------------------------------------
  898-  930 (41.12/34.16)	EDFYYD.ELNtsvhdEVARLNARTISDILNASEN
  933-  961 (46.34/26.71)	KSFFQNqEMN.....PLNNLGTPSIDEIFNTSFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.98|      10|      21|     842|     851|       5
---------------------------------------------------------------------------
  842-  851 (19.09/ 8.86)	FKGTFNFPKI
  866-  875 (18.89/ 8.68)	FSSNNGFPNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.45|      17|      26|     174|     190|       6
---------------------------------------------------------------------------
  174-  190 (30.15/19.52)	VAVLHGGKGQDAREHSL
  202-  218 (28.30/17.90)	VATDVAGRGIDIKNVSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10679 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQMMENNMMYQNSHIPDITDDDRRMRLEALKQ
2) SLYNVPLQQQSGPIAPKIENIPMVRPQMNNQEFGVHNQWMPQNQMNSPMQQPNYHPHGPPNQLPQGGHNPYVVPGSPSTSQNVRHSPYPLPPKNHFGNYNRPQNIGQQQQPQNQFNNYGYNGPQLSGSMPTSSTFDDGFNNFDPFMGMNDGTMTSNNSNSSSVQNMY
3) SVPSAINSSFNKNGMSPTTGINPPSNIPPDPQPTQQNDTSNLTMSSGAIGGNLNNMTINQQQNSNMIPNDSRLAHVTPMVQNKMAMGGGVSGMGGMANQMGSNQMSGYNNGPIPNSSPINNQQNFIQSGQASNRFPNRPINGPPNFDNNICDMNPFGQGSSPNMSGVGPLNGPNMYNQQVDGNKGVMVNEMMGNNGGINPNKRPLYNQQEQQFMGNGGMMRTHSGNMGMMSNQQGYNNYNNYQG
565
648
319
596
814
562










Molecular Recognition Features






MoRF SequenceStartStop




NANANA