<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10678

Description Uncharacterized protein
SequenceMSMIDARFREELARRREKVEDIYHFHNQKIGRGTYGHVYKAVPRIPSTEVYALKLIEGTGLSMSACREISLLRELRHVNLIKLQRVFLTAERKVWLLFDYAEHDLWHIIKYNRSMKSKKQRVDVSATMVKSLLHQILDGMHYLHSNWILHRDLKPANILVMGEGLRERGRVKIADMGFARIFYNPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDLWAIGCIFSELLTSEPIFFCREEDIKASSPYHKEQIQRIFQIMGYPAEADWTDINKMPYYDKLKNDFKREKFANFALSKYMDKHKVKTDTKQFALLQKLLTMDPMKRISAQGAMEDDYFKELPPTTLDVFNGLEIPYPKREFLSDEEGKDPLANMNLQPQQPQAQPPPNKRIKMDVENEQFNKNMNNPHDMNQQGNHVANNLQEQQPQMSMYADNNLRNRPQPPSQYNQMYNNNDLARRQQEQLREHKMKEEIQQQHTFQQQQQRNMMMHHHGGPNPNQGRDIQMGIMNFEQQGHANRPPNLIMPDNNRDPNTGQFQNVQQQRMMQQQQQQMHGMPNNPNYGWQGPNPRYNPQ
Length571
PositionKinase
OrganismRhabditophanes sp. KR3021
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Alloionematidae> Rhabditophanes> unclassified Rhabditophanes.
Aromaticity0.09
Grand average of hydropathy-0.882
Instability index58.80
Isoelectric point9.14
Molecular weight67394.20
Publications

Function

Annotated function
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
GO - Biological Process

Interaction

Binary Interactions

Repeat regions

Repeats

>MDP10678
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     152.18|      29|      29|     393|     421|       1
---------------------------------------------------------------------------
  363-  390 (38.04/14.64)	DEEGKDPLANMNlQPQQ..PQAQPPPNKRI
  393-  421 (50.07/21.47)	DVENEQFNKNMN.NPHDMNQQGNHVANNLQ
  500-  521 (36.61/13.83)	DIQMGIMNFE.Q.QGH.....ANRPPN.LI
  528-  548 (27.45/ 8.63)	DPNTGQF.QNVQ.QQRMMQQQQQ.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.65|      17|      18|     424|     440|       2
---------------------------------------------------------------------------
  424-  440 (33.26/15.41)	QPQMS.MYADNNLRNRPQ
  442-  459 (28.40/12.30)	PSQYNqMYNNNDLARRQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.60|      17|     170|      82|     121|       3
---------------------------------------------------------------------------
   63-   81 (25.16/20.98)	MSACREISLL.....RELRHVnlI
   88-  109 (26.44/38.31)	LTAERKVWLLfdyaeHDLWHI..I
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.08|      23|      25|     228|     250|       5
---------------------------------------------------------------------------
  228-  244 (23.67/12.62)	.......ELLTSEPIF....FCREEDIK
  245-  270 (28.98/17.09)	ASSPYHkEQI..QRIFqimgYPAEADWT
  273-  288 (23.43/12.42)	NKMPYY.DKLKND.......FKRE....
---------------------------------------------------------------------------




Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP10678 with CDK8 domain of Kingdom Metazoa

Intrinsically Disordered Regions

IDR SequenceStartStop
1) PKREFLSDEEGKDPLANMNLQPQQPQAQPPPNKRIKMDVENEQFNKNMNNPHDMNQQGNHVANNLQEQQPQMSMYADNNLRNRPQPPSQYNQMYNNNDLARRQQEQLREHKMKEEIQQQHTFQQQQQRNMMMHHHGGPNPNQGRDIQMGIMNFEQQGHANRPPNLIMPDNNRDPNTGQFQNVQQQRMMQQQQQQMHGMPNNPNYGWQGPNPRYNPQ
356
571

Molecular Recognition Features

MoRF SequenceStartStop
1) YGWQGPNPRY
559
568