<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10668

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPSYEETLKQQSLIRNLGSLIDQTSPSSDPCVLPKTNCISNYDLERCSSYIISQVDIEELDTRVVDVIQNSFIDLDNFENCVPTKKRSMADYPCFVHPWGLQKVNNMPDVSDGDYIDLLNIIGRHFEEVLKVEKKTPGSKGSQTVSEKSLSWKELCHRSSKNRGQETDGSVSEIIPSILVGSEKDLVISSPQIISSWEKLFLSPYDQSKDVLYFAIVPDDNIMVDKAKLFFDEVSRTYEGWRLGKHAKITKDFVKDGIIRVPTNVNIKPNCNSRAFQAFFDKLDRENEDEVLVKKLKAYASFCELQLATFFKNNDSLFERKAYCEILYRENSQSIKNDDTSQMDLMATTNSNVSNTDNFSRSSFNNSVNDTSVGETATVADHLIPEDEFPVLPHIIVIYLINPFNFDVNNRTSKATRLANISLMRAFNLFISQLAESRRCSIQLELINLSSIMDLTGLFFDVYREGRLMFDEAMLSRNKSDNGMAFELIKSIVISVYTHTRIIQPSVVSNYIPKSMTRFGPSSDIQDILKDIAAQKPMYLKVSCSLATLAPTTAFGINVENTFLNPAPEEKILHVSYCLIQDKWLVGAVTDDQGLLLDNTVINLETPKERNKMPKYFAGSQILDALTRFWQYIMGVLAMEVKNWRLIIGRVGKVGHGEFKTWMLLLSKNNIKRYNTRLKEACNTCNSSTTFHETPAIASACFISLEAEPYLRVFLTPSTIPINPETKEPIANKYSSKTHMPLDISSTHITVFPTSAEIIVDNHQDNDDHGIEDLSDLVFEDDIGTLVETLGLDATTEENNLTSSYIKQSENIFFNLNISDISISSQPLAAGFIISAAPANDLPNWFWAQCPTRKNKSPVHLRSSLHINTNNIFQSDDDYSNTAVLENQHPLDSSKTDDVLRYVLESYNQLSWLNVDIITGEKKSCLPLHIQALLRLYNTIEKLIL
Length945
PositionMiddle
OrganismRhabditophanes sp. KR3021
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Alloionematidae> Rhabditophanes> unclassified Rhabditophanes.
Aromaticity0.09
Grand average of hydropathy-0.261
Instability index43.10
Isoelectric point5.18
Molecular weight106863.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10668
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.48|      15|      41|     277|     291|       1
---------------------------------------------------------------------------
  277-  291 (25.81/14.05)	QAFFDKLDRENEDEV
  321-  335 (26.67/14.73)	KAYCEILYRENSQSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.71|      13|     227|     200|     230|       2
---------------------------------------------------------------------------
  174-  187 (17.32/25.51)	IIP..SILVGSEKdLV
  216-  230 (18.39/ 6.59)	IVPddNIMVDKAK.LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.29|      91|     402|     362|     460|       3
---------------------------------------------------------------------------
  362-  460 (136.90/106.93)	SSFNNSVNDTS....VGETATVADHLIpEDEFP.VLPHIIVIyLINPFNFDV....NNRTSKATR.laNIslmrAFNLFISQLAESRRCSIQLELINLSSIMDLTGLFF
  745-  847 (140.39/86.11)	SSTHITVFPTSaeiiVDNHQDNDDHGI.EDLSDlVFEDDIGT.LVETLGLDAtteeNNLTSSYIKqseNI....FFNLNISDISISSQPLAAGFIISAAPANDLPNWFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.15|      30|     402|     241|     272|       4
---------------------------------------------------------------------------
  241-  272 (51.23/44.35)	WRL..GKHAKITKD........FVKDGIIRVptNVNIKPNCN
  644-  683 (43.92/30.19)	WRLiiGRVGKVGHGefktwmllLSKNNIKRY..NTRLKEACN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.83|      26|     492|       4|      29|       6
---------------------------------------------------------------------------
    4-   29 (44.16/29.05)	YEET.LKQQSLIRN.LGSLIDQTSPSSD
  497-  524 (38.67/24.52)	YTHTrIIQPSVVSNyIPKSMTRFGPSSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.85|      12|      42|      66|      77|       7
---------------------------------------------------------------------------
   66-   77 (21.85/11.45)	DVIQNSFIDLDN
  109-  120 (22.00/11.58)	DVSDGDYIDLLN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10668 with Med13 domain of Kingdom Metazoa
Unable to open file!