<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10655

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSNGSVSPGSNIPTTSLEDCSTNIFQIAEINGLKWCCFTSNFSSNSPTLKAKSLTSTYAGVVGTENTDPVLRAYFDCLKENLLCTWRRRPPIASASAAYDNPIPRPDTQKELWIFWYTSEEPKLVEDFKSRGLNVVTHSESTDADAPRVEFEYETRTLFFKSLNSSIERRLLTEGFVRFGRWLCRPLELSPLYAEDKNTIPKFMNAIRFHYFLHRDSLVCASIVVQRQPSILRLSQCHFKEETQCTQPVVLAPWSIRAQLLPNQQNFLGDINTGKTVISSPNEEDTSFLSSTLSPEKNDEDGTCSKRRSSQIVESHWKEWKRIYPSLELLTTNSNGNKSSSNSANNKRRTSSGIFSSRGNSLSSLPRMVVIQLGGQFLLYPSAFVGILVDELIGPLPSKKTKSTLMADEATCGDILMDNVLDKPEKSSHSFSTRKSDFRTSQIRRHIYTGLFAARASFGLGCLRNPKNRISEAEHSDPFNYDLQQQRASDSMAEFGYDYMRREFCYCRICPQLGRSFPAVSSLTNLQKESQTCQTTANSLISNIHHPTTSFHRLEVFNEEIESNVDSSGRRHLFNSLSKNLSHRTRNFRPRIVNSSRSSSAMITSTSIPSHSRWMDSLDNSPDSSKISIQSKEHWGILNVLDEQIFFTPNNSNVLLDDQIINQTIHTSSSNGTINLESHCDIKPSTSFLYQQLQPNTCTSELERMILGDDDDDSEQQKVACPVNEGDPLGLLQRLVHQNLNQNLKWRKRKRKWNCVGIKSKKRKQLSWPTLSSLELLNIAHTEEKSNMFSDNPHSLLPLVNSDISHSIWQQISQHPASTVHQTSVSSHQPQSILMRMLISPSTEGIDAQQQQQYLNGKQPDISQQQNSVMAPIRTTNITEGLMAISQQQIISTTNQQIIDEHMDEYAVTPPALLDSDATLAIDHQQQQMIDQQVKDQQGIEMNIALHEMSFEERIHACSHSSLDLYSPPSTSGSALQTLFQQQHTPQNTILSPPASNERVDSVNAGGIPSTQIFHGGIPTTSNCATTCISQPTYSTMAAAAANAILQESMSKIYPTPPTPAQQFSPQNILLFSHHHLSHQFQSLSQPPVNTEQTIVSILGYFSEQLQHLPWEEPIYGSSDHNKAHTRHFCKNILSISDNIRDDKLNDINCVECSNILISLENQNQHNRPLKRACCESESIDKVTPNFMLKMLPNVGTLPTMHLHALAQRRSKADSQLEHRLQMEEQARFRVLVGNNSSEHVPQWSGGTWPVNFSQGPPPFPPIPSTHPHQQQGIRNFGPSIPIFQGSVQPMISQNEHFFGGHPMPITPLYHHSFARTPQQQLARQASFANNVQMSPQLQKASITNPLRSPPHTPSTSNPSPAATQTVNQIMAHYSDFVSPATIATTFKTLQPMTGNITTIFGKKFQDFLLNTNLCNFSLITLLIQDTIADLHYDIVFDACPLCCCNSNIRSFELGFYITSPINFLEFCDNLQQKQRQQHPQALLLKQWSGFRIPPVELQKCICGFSAVRHRYLCGQGSGLFQQDIDEALGSIYKPSQQSLLYNFNPNNLSDCKLIDLIRHLVISRDVSPLVRGRLSFVVNSTHSSEYLPYVDRFELNTRVNEIMSVCGIVLERQKGQGEDESILHPWGYQYANSVGEPRDTECLGIFDEVCDILRDPSSPPLVSCFSSNGRRFDQLTLRLFARIKNVGAIGSNNRVGEDENGRPEPIPKVIALSCTEREPLLLSPTMIRNWEQLELMPIDQPKDVLYLALVPDVNVLAEKCKIFLEELSSVYERRCRLGSHTRLEIKDSPKDAILRVGSSSSPLNLGYQMFTSLSTLFTRFGFNQHLNDPIIQKFASYMECCKQELQELAKFLTSNDFIFERRALLESIFRQQHIAQTTSLASPPDANAMPPPAMPNGSCYTFFTSSGQSSNALGVLAENGVNSSAIHQHPSPLSTPGFANQQQSPAGGSGPNSVPILHGNVGGDSSKAATSLLRTPSGTETAEELAKREDKLAKEMREQVDLLLSKEEQARRLQMPHVLVIYLINPFGQFAVTDHQQRHEQNASETSTGFSEKFEALSTAALLHAWNDFLSLLNYKRRSQLQLELLPIRKIYDYCAFMGMGDQQWDAGWRISAWDELRRMAFSIYTQPRLIHSNIAQEALSKSMTKFGTAEKMKEIFLTLGDNMFLLKQNCSPFLLAPERSINFLPHGHSNSLAISAITGSGNIGSGIGSQHTSGHKLQLLSADERILFLAYCLIADGNWLCASVTDERGSLLDTTLINLNAPSEDTLPPLEPQKEWKHKERHSQIADALQRLWLFVRSVMLGQEVHQWRLVINRMGKLGHAEFKIWNDMLSKRSLKAYNCSLKNNQSSVDGLSASTAFLNNCQACSNSHGWHETPALLSACLVSTEAEPHLRVFGSPCASTNSLDGQSPANGGVSNINSNTSNVIGSSASNIGNSANTKIGSSKGAGRHSLLQAQQWAAAQQQLQASPDDRSLTHIIVFPTILNVSCQQQEDIMHGGIDDDVFADFLGNCFSGDGAPDGMELVEDLVFDEGPRNEEEAPIDNQPMAIGYTITTAPVWPSSSRLDIPNGSSLSLDCGLSDAFWHNCPPASRQRRLAHLKSSLHINSTNLLQTDDYQQTTGKNASGPVGNQTNGNTITGTDKLAPNPLDLPNTDDILRYVLERQNALSWLNLDPVSGSRCSCLPIHMQAIHRLAESIGTIFGSS
Length2704
PositionMiddle
OrganismMeloidogyne hapla (Root-knot nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Tylenchomorpha> Tylenchoidea> Meloidogynidae> Meloidogyninae> Meloidogyne.
Aromaticity0.07
Grand average of hydropathy-0.417
Instability index56.18
Isoelectric point6.22
Molecular weight301494.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10655
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     722.07|     224|     261|    1009|    1268|       1
---------------------------------------------------------------------------
  793-  876 (60.40/18.37)	................PHSLLPLVNS.DISHSIwQ...............QISQHPASTvHQTSVS.....SHQPQ.........................................................................................................................................................silmrmlispstegidaqqqqQYLNGKQPDISQQQNSVMAPIRTT..................................................................
  970- 1052 (59.51/36.30)	STSGsalqtlfqQQHTPQN...............................................................................................................................................................................................................................................................tilsppasnervdsvnaggiPSTQIFHGGI.PttsncattCISQ.PTYSTMAAAAANAILQESMSK
 1058- 1316 (372.55/198.79)	PTPA........QQFSPQNILLFSHH.HLSHQF.Q...............SLSQPPVNT.EQTIVSILGYFSEQLQhlpWEEPiygssdhnkAHTRHFCKNILSISDNIR...DDKLND..INCVECSNILISLENQNQ....HNRPLKRA...CCESESIDKVTPNFMLkmlpnvgTLPTMHLHALAQRRSKADSQLEHRLQMEEQARFRV........LVGNNSSEH...................vpQWSGGTWPVNFSQGPPPFPPIPST........hphqqqgirnfgPSIPIFQGSVqP........MISQnEHFFGGHPMPITPLYHHSFAR
 1317- 1521 (229.61/97.74)	.TPQ........QQLARQA..SFANNvQMSPQL.QkasitnplrspphtpSTSNPSPAA.TQTVNQIMAHYSD......FVSP.........ATIATTFKTLQPMTGNITtifGKKFQDflLNTNLCNFSLITLLIQDTiadlHYDIVFDAcplCCCNSNIRSFELGFYI.......TSPINFLEFCDNLQQKQRQQHPQALLLKQWSGFRIppvelqkcICGFSAVRH.....................RYLCG.......QGSGLF........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.29|      17|    1405|     992|    1008|       2
---------------------------------------------------------------------------
  992- 1008 (31.46/19.72)	SPPASNERVD..SVNAGGI
 2398- 2416 (27.83/16.35)	SPCASTNSLDgqSPANGGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     287.03|      85|    1111|     563|     652|       5
---------------------------------------------------------------------------
  567-  652 (143.39/85.88)	SSGRRHLFNSLS.KNLSHRTRNFRpRIVNSSRSSS...AMITSTSIPSHSRWMDSLDNSPDSS.KISIQSKEHWGILNVLDEQIFFTPNNS
 2048- 2129 (115.48/57.83)	STGFSEKFEALStAALLHAWNDFL.SLLNYKRRSQlqlELLPIRKIYDYCAFMGMGDQQWDAGwRISA.....WDELRRMAFSIYTQP...
 2543- 2571 (28.17/ 7.91)	........................................................DNQPMAI.GYTITTAPVWPSSSRLD.....IPNGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.63|      67|    1111|     423|     496|       6
---------------------------------------------------------------------------
  423-  496 (101.70/74.46)	KPEKSS..HSFSTRK.SDFRTSQIRRHiytgLFAARASFGLgcLRNPKNRISEAEHSD...PF..NYDLqQQRASDSMAEFG
 1534- 1608 (98.93/53.97)	KPSQQSllYNFNPNNlSDCKLIDLIRH....LVISRDVSPL..VRGRLSFVVNSTHSSeylPYvdRFEL.NTRVNEIMSVCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.58|      11|    1090|     842|     852|       7
---------------------------------------------------------------------------
  842-  852 (20.03/13.41)	STEGIDAQQQQ
  878-  888 (19.56/12.89)	ITEGLMAISQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     320.19|      96|    1633|      75|     170|      10
---------------------------------------------------------------------------
   75-  170 (169.28/109.08)	FDCLKENLLCTWRRRPPIASASAAYDNPIPRPDTQKELWIFWYTSEEPKLVEDFKSRG...LNVVTHSESTD....ADAPRVEFEYETRTLFFKSLNSSIERR
 1673- 1775 (150.91/96.34)	FDQLTLRLFARIKNVGAIGSNNRVGEDENGRPEPIPKVIALSCTEREPLLLSPTMIRNweqLELMPIDQPKDvlylALVPDVNVLAEKCKIFLEELSSVYERR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.96|      40|     267|    2225|    2272|      12
---------------------------------------------------------------------------
 2225- 2272 (57.64/57.81)	DERIL..FLAYCLIADGnwlcasVTDerGSLLDTTLINLNAPSEDTLPPL
 2501- 2542 (68.32/43.86)	DDDVFadFLGNCFSGDG......APD..GMELVEDLVFDEGPRNEEEAPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.93|      19|    1631|     333|     353|      13
---------------------------------------------------------------------------
  333-  353 (29.44/28.35)	NSNGNksSSNSANNKRRTSSG
 1961- 1979 (33.49/24.25)	NVGGD..SSKAATSLLRTPSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.24|      16|    1921|     676|     692|      15
---------------------------------------------------------------------------
  676-  692 (26.73/22.66)	LESHCDIKpSTSFL....YQQ
 2599- 2618 (23.51/13.00)	LKSSLHIN.STNLLqtddYQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.04|      16|      16|    2346|    2361|      16
---------------------------------------------------------------------------
 2329- 2344 (24.82/12.52)	NDM..LSKRSLKAYNCSL
 2346- 2361 (25.52/13.11)	NNQ..SSVDGLSASTAFL
 2363- 2380 (24.70/12.42)	NCQacSNSHGWHETPALL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10655 with Med13 domain of Kingdom Metazoa
Unable to open file!