<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10652

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAAAVPSNERSDGPTADDDWPSQLFRDHVIIRLEPELARNRQNAPNLPVPGDARQVEEYVFQKCGSKDEYMRTIAKVINAINCNSKSTAMPPVFQAQQQGGVRQPSSTSLLTQLGSGGVTPTTPTSSYKAQIPPDPQPTHQQQQIRFPLQQQPSNTSIDQTSFQMGQPPPIMMTNSLQQFPSQNDQIEVAPDPSMQNSSMGVMDYGRIQQQQQGTFTPQQYQQPMMGGQSMPQQQQLPLTGSSAAPLAMQNSGRSINKMLTDSQMQQQHSQLLLQQQRHWIAQQQQKQQNYIPPQQQQFGIPQQNFMGNQQMTTGGMIPQGNANMMLPQYGGGQTAQMMTEYPPNFPPEIIQRLKAMGPNERPYFEKVCQLQQFVGFLQSSLIKYQADVAMVSRINTMLSVLRFERFMGMNELNDIEIVIRKMMFTSHPGYAAQLQQSMIPQSTMDPYAAQIGSQMHPAASNWSEWSTLQNTQQNAAMASGMMRGGSSVGYSSSGGATMQKVVQPTQASSYMPAGVNTSSAFFGNAPTSQPGGIAPISSSQSQPPYSSGMMIDQKYQLQTSQQQQQQQQQYSTYSQQQYTQQQQRQTFGNALDNSNTTTMSTSNQPIMTQQMQQWPATTGDAAAIDDLYSSMDDLLPVPTEQQTPSSSANSGRPMNLDGMLGIGGGNASGRSSGITVNISQLPDAIRSEIADLEQRFQFDPSVEIASDMNSFVIKCILRSQQVPPLRLIIPRGYPVGSVTVERAILDLDSFYFDDLQNFIHEQFGKLNSRTITDILNTWENAVQQFYASGQMGQNNFEDFSGFTN
Length805
PositionTail
OrganismMeloidogyne hapla (Root-knot nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Tylenchomorpha> Tylenchoidea> Meloidogynidae> Meloidogyninae> Meloidogyne.
Aromaticity0.07
Grand average of hydropathy-0.629
Instability index61.75
Isoelectric point5.11
Molecular weight89162.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10652
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     257.63|      54|      54|     159|     212|       1
---------------------------------------------------------------------------
  141-  207 (85.10/28.35)	.QQQQirfplqqqpsntsiDQTSFQM...GQPPPIMMTNSL...QQ..FPS........QNDQIEVAPDPSMQNSSMGVMDYGR
  208-  254 (57.86/16.46)	IQQQQ.........qgtftPQ.QYQ.....Q.P.MMGGQSMpqqQQ..LPL........TGSS..AAP.LAMQNS.......GR
  256-  317 (67.29/20.58)	INKML.........tdsqmQQQHSQLllqQQRHWIAQQQQK...QQnyIPP........QQQQFGIPQQNFMGNQQM..TTGGM
  530-  578 (47.38/11.89)	..............................QPGGIAPISSS...QS..QPPyssgmmidQKYQLQTSQQQQQQQQQYSTYSQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.43|      16|      16|      94|     109|       3
---------------------------------------------------------------------------
   94-  109 (30.62/16.10)	FQAQQQGGVRQPSSTS
  111-  126 (26.29/12.58)	LTQLGSGGVTPTTPTS
  147-  157 (21.52/ 8.70)	FPLQQ.....QPSNTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.50|      22|      26|     613|     638|       4
---------------------------------------------------------------------------
  613-  638 (33.25/31.00)	QQWPATTGDAAAIDDLyssmDDLLPV
  642-  663 (39.25/24.54)	QQTPSSSANSGRPMNL....DGMLGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.52|      14|      53|     451|     464|       5
---------------------------------------------------------------------------
  451-  464 (26.86/13.72)	QIGSQMHPAASNWS
  494-  506 (19.20/ 7.68)	SGGATMQKVVQP.T
  507-  519 (22.46/10.25)	QASSYM.PAGVNTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.04|      13|     312|     471|     483|       6
---------------------------------------------------------------------------
  471-  483 (25.54/13.93)	NTQQNAA...MASGMM
  777-  792 (21.49/10.64)	NTWENAVqqfYASGQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.68|      11|      16|      64|      74|       8
---------------------------------------------------------------------------
   64-   74 (21.31/11.75)	CGSKDEYMRTI
   83-   93 (21.38/11.81)	CNSKSTAMPPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10652 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGVNTSSAFFGNAPTSQPGGIAPISSSQSQPPYSSGMMIDQKYQLQTSQQQQQQQQQYSTYSQQQYTQQQQRQTFGNALDNSNTTTMSTSNQPIMTQQMQQWPATTGDAAA
2) KSTAMPPVFQAQQQGGVRQPSSTSLLTQLGSGGVTPTTPTSSYKAQIPPDPQPTHQQQQIRFPLQQQPSNTSIDQTSFQMGQPPPIMMTNSLQQFPSQNDQIEVAPDPSMQNSSMGVMDYGRIQQQQQGTFTPQQYQQPMMGGQSMPQQQQLPLTGSSAAPLAMQNSGRSINKMLTDSQMQQQHSQLLLQQQRH
3) LYSSMDDLLPVPTEQQTPSSSANSGRPMNLDGMLGIGG
514
86
628
624
279
665










Molecular Recognition Features






MoRF SequenceStartStop




1) DWPSQLFRDHVIIRL
19
33