<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10635

Description Uncharacterized protein
SequenceMDEFEDHGPPHIRLNVLLDFAVQQIYHDLTVLVELLPKKRDMDRKISIVKFAHDTRGLFVKILAAVKWLKTAGRFETCSSIMHFLDEQSSYFVETADRLVELARVELVHARIPCYQMAIASDTLTRTTYARLPLCIKKCFIPDAPITKKEQIQILHRLNHVIQNRLSQYSSKLSKRIKKIKVKNGTVTLEVPGEFEVTLTLLGERQDTDWTLLNIKMLVKDYEVGYGTTLVHPNQLNMLHNVLQARMLRSKQPITEVYNFLHHFAMNLQLDLLFCQTQMLLTGPMKAYVCIEKYSPNQGLLQIGYWMKRLSNNRWASQYRLVISFDADKPEKGLRIRHHPSCKGLEDPDIDDRTGHLSIEKVLSETMYIRCLERMLRLRTRLESIKPLRKVKFSGNHVPTLMWPLAAEGDDGGVDIPEDEYLSVGVNMFSGRVVCVVKALGPVPEIVKLEGLLTESAAADVVSRHISRLRVLLMMDRYQKAVSGLQVRIVKDVAMLPMLKELQQIPADRIYLQFLRDEHHFLVIAFTPNPESGIMVELYLYSTRNPNNRIQKIDIEKTADWYGVPHIPESGAVVVPKRSSCSTFVKEEIPADEDYERMDVDEDKPSTSYCWSNLHTRMGAVVSAIDDRLAFATVINELEKREVVMDKLSCEPVVGGLILRIRDLSKAISSVDNYSDFLDNISQITLRLDTRNKVYWPLECTLKNVIINADNLSVKGEFSPGPYSFIQELSGPGGNVASDTVASSLIQRFVSYAELYKTVAPFAKAYEAYYKNFCTVNGYYYNKIALAYGEQRDQLMILAYKAKTKTFSLTFGMASAPPTTGSRKPLRWNAHTMMASILNERFRQKKDLIWLVNYLIGTSAPLLALHNFSKMKLRSTKPLAQMMGIEQNFPVEMESHFIVASENIVLLMFGNIHIEINFLQVGKVGMRDCSPVKPLAYGLEAFWNRMKPDSKDVKGGFKPNSPMPNSPYQSQKPLSVPSHHLSQSPMMNMSLSVPPAHGFNDFFESSSPRGQTSPRSTFKKGPSLMASRAAFAVDHKTFEIGLSAEDRQKSPFAEYLFGLTAVSRFIAVINAFRQNNQRLGNFALDIIDMKIHNAAFKLCFNGANPTQNIKPWVVQSNVYMDQSIFKLKLRLDFNGSSVPNEESVRIAERYFEESVLPLQNEIAFFALLTVCRMASPGVFHDLTRIMSSQMDPDPTLPWKIGMQLVMEANAQVQGPQKKYVVGVVPNSSCSSFVFIICLRPTKKGTTLSQRYQLQFVYNLVNNVIEPRQPANDPTLTRLVKEGVERAQQSGECSIWPAIDNVMKNYTISTGSS
Length1312
PositionTail
OrganismSteinernema glaseri
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Steinernematidae> Steinernema.
Aromaticity0.09
Grand average of hydropathy-0.187
Instability index41.42
Isoelectric point8.93
Molecular weight148816.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10635
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.92|      29|      32|    1097|    1128|       1
---------------------------------------------------------------------------
 1097- 1128 (44.68/46.34)	KLCFNGAN.PTQNiKPWVVQSnvYMDQSIFKLK
 1130- 1159 (45.24/33.47)	RLDFNGSSvPNEE.SVRIAER..YFEESVLPLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     968.00|     301|     638|     119|     440|       2
---------------------------------------------------------------------------
  119-  440 (473.18/361.65)	IASDTLTRT......TYARLplciKKCFipdAPITK..KEQIQILHRLNHVIQNRLS.QYSSKLSK.RIKKIKVKNGTVTLEVpGEFEVTLTlLGERQDTDW.......TLLNIKM.LVKD..YEVGY..GTTlvHPnqLNMLHNVLQARmLRSKQPITEVYNFLHHFAMNLQLDLLFCQTQMLLTgpMKAYVCIEkyspnQGLLQIGYWMKRLSNNRWASQYRLVISFDADKPE.KGLRIRHHPSCKGLEDPDIDDR................TGHLSIEKVL...............SETMYIRCLERMLRLRTRLESIKPLRKV..KFSGNHVPTLMWPLAAEGDDG.....GVDI......PEDEYLSVGVNMFSGRVVCVVKAL
  601-  729 (59.51/25.36)	.....................................................................................................................................................................................................................................DEDKPS.TSYCWSNLHTRMGAVVSAIDDRlafatvinelekrevvMDKLSCEPVVgglilrirdlskaisSVDNYSDFLDNISQITLRLDT...............RNKVYWPL..ECTLK.....NVII......NADN.LSVK.GEFSPGPYSFIQEL
  736- 1072 (435.31/278.63)	VASDTVASSliqrfvSYAEL....YKTV...APFAKayEAYYKNFCTVNGYYYNKIAlAYGEQRDQlMILAYKAKTKTFSLTF.GMASAPPT.TGSRKPLRWnahtmmaSILNERFrQKKDliWLVNYliGTS..AP..LLALHNFSKMK.LRSTKPLAQMMGIEQNFPVEMESHFIVASENIVLL..MFGNIHIE.....INFLQVGKVGMRDCSPVKPLAYGLEAFWNRMKPDsKDVKGGFKPNSPMPNSPYQSQK...........plsvpSHHLSQSPMM...............NMSLSV...PPAHGFNDFFESSSPRGQTspRSTFKKGPSLMASRAAFAVDHktfeiGLSAedrqksPFAEYL.FGLTAVS.RFIAVINAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.78|      26|      83|     483|     511|       3
---------------------------------------------------------------------------
  483-  511 (37.19/35.34)	SGlQVRIVKDVAMLPMLKElqQIPADRIY
  570-  595 (46.59/31.42)	SG.AVVVPKRSSCSTFVKE..EIPADEDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.03|      33|     432|       8|      44|       4
---------------------------------------------------------------------------
    8-   44 (54.42/53.33)	GP.PHI.RLNVLL..DFAVQQIYHDLTVLVELLPkkrdMDR
  441-  477 (43.60/31.67)	GPvPEIvKLEGLLteSAAADVVSRHISRLRVLLM....MDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.15|      14|      31|      47|      60|       6
---------------------------------------------------------------------------
   47-   60 (24.47/12.63)	SIVKFAHDTRGLFV
   80-   93 (25.68/13.55)	SIMHFLDEQSSYFV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10635 with Med14 domain of Kingdom Metazoa
Unable to open file!