<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10617

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSSEDDWPSQVFRDNVISRLEPELARNRQNAPNLPVPGDARQVEEYVFQKCVSKDEYMRTIAKVINAINCNSKSAAVPSVLQTQYKGFPGGNGSGGGTNGAVPGNQVMPNGGGVENFTLSLSFSMPTSMDQKAISPNMGNRAPGVPPDPQPTHQQRQQANNQYANNSAGSGGPMPNAAGGNPLGQPPPMMAAQAAAGAVNGISPQQHSAAQQASQMNQGNHMVSPQQQAHMMNNSGNPMMGPYGMQQQPPYGMHPYGPYGGNHMVSPQQQAHMMNNSGNPMMGPYGMQQQPPYGMHPYGPYGGPPQEQQRQMKMERPPTAVPEGMWGQQQGQQQQMNPMYMQGPPMMAPYVSNMDHQMHPQYHPAHLNQMNAANQQQAPVSSSSVLENLINQPHYVNQGGAMPTSTSSASRMGGEFPLGNLHGFNAGGAAGGGAAGDAAQNIQMSPEEREKYDKKLLEMRKVLPALKQRAQEFRAQQKIDVAEKFDVFVSVLERRKVLNLEYLKNFESWINRKLDLIMNSQRQFDYGQPGMMGSPYXXXXTRQVRRGWAG
Length550
PositionTail
OrganismSteinernema glaseri
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Tylenchina> Panagrolaimomorpha> Strongyloidoidea> Steinernematidae> Steinernema.
Aromaticity0.07
Grand average of hydropathy-0.809
Instability index53.77
Isoelectric point8.81
Molecular weight59518.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10617
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     320.48|      39|      39|     221|     259|       1
---------------------------------------------------------------------------
  124-  152 (44.09/ 9.65)	SMPTSMDQKAISPN...MGNR..A.....P.GV...PP...DP..QPT
  153-  195 (41.58/ 8.71)	HQQRQQANNQYANNsagSGGPMPNaaggnPLG...QPPPMMAA.QAA.
  221-  259 (92.83/27.95)	HMVSPQQQAHMMNN...SGNPMMG.....PYGMQQQPPYGMHP.YGPY
  263-  301 (92.83/27.95)	HMVSPQQQAHMMNN...SGNPMMG.....PYGMQQQPPYGMHP.YGPY
  333-  365 (49.14/11.55)	.....QQQMNPMYM...QGPPMMA.....PYVSNMDHQ..MHPqYHPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     317.58|      79|     335|      27|     110|       2
---------------------------------------------------------------------------
   27-  105 (135.91/61.62)	NRQNAPN...LPVPGDARQVEEY.VFQKCVSKD.....EYMRTIAKVINAINCNSK.SAAVPSVLQTQYKGFPGGNGSGGGTNGAVPGN
  368-  441 (101.70/43.50)	NQMNAANqqqAPVSSSS.......VLENLINQP.....HYVNQGGAMPTSTSSASRmGGEFP.L..GNLHGFNAGGAAGGGAAGDAAQN
  466-  534 (79.96/34.44)	LKQRAQE...FRAQQKIDVAEKFdVFVSVLERRkvlnlEYLKNFESWIN....RKL.DLIMNSQRQFDY.GQPGMMGS...........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10617 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PYGMHPYGPYGGPPQEQQRQMKMERPPTAVPEGMWGQQQGQQQQMNPMYMQGPPMMAPYVSNMDHQMHPQYHPAHLNQMNAANQQQAPVSSSSVLENLINQPHYVNQGGAMPTSTSSASRMGGEFPL
2) SVLQTQYKGFPGGNGSGGGTNGAVPGNQVMPNGGGVENFTLSLSFSMPTSMDQKAISPNMGNRAPGVPPDPQPTHQQRQQANNQYANNSAGSGGPMPNAAGGNPLGQPPPMMAAQAAAGAVNGISPQQHSAAQQASQMNQGNHMVSPQQQAHMMNNSGNPMMGPYGMQQQPPYGMHPYGPYGGNHMVSPQQQAHMMNNSGNPMMGPYGMQQQ
292
79
418
290










Molecular Recognition Features






MoRF SequenceStartStop




NANANA