<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10583

Description Uncharacterized protein
SequenceMSGKTSSVVTWYQSTADKRLLKKHKIGPPDVHPQEAKQEEDNLSQDRLRKGYQISYRKSEINSAILDKERKKNKEAASAQFAHNVGTSKTKERAAWFTDLSRGKALSQLAKKIPLLKRRDEGLEYLCDYKITPFRALWYMKITAALTVTTQVKQKKTTNDMYSTEYAQVFCRSFRDLLNKMWDISDLSSSSLYKERWLYVTSLSKMAFEDGILDWQEFLNELCEVFSDFFIRGVHKTEEKTPQLRIYLLFLAQFVRHINMNLILARRTAHMIAMKLRLMKIDYDEKHETVTKGGEVYNTLTQCSAQRTVIYVLSAILQNIVIDAPSAVIWNKFRVDSSILILNMILSKITFYVNTFFRIKLMLHWAVTAEREGSYRAVIVTKVIHQQVINQQSLMFGPFHMQDIILNYFYTEAPLVGSKFYHQEFASLVMLFTELCRFKLFVHDCFVKDLIKTGELDYQKPAMNKFKDESKTAENQGSTGVIKSQFEDLTPDEPPKPNGLIIPKPDDKDEHILLEDPMTMNDRILIQIAKEICKIWQKKIYVQFYDNADTVWCPRRMNSQKITETLSKFKCQTYYDQMVICGWCAESFSDMIRDFVQGNSLQMPTSEGLDILCGMFETAQYIYGIFELCEAVVPLLTPTEKVIRSLASDCIPGSVSGQLGYVFVAYLCKHWHYFLHSDRAPVITNQLYELIERMIRAHEYPVTSWGRTIAAFLTDVKIHGAHADFRNVFNHGSSSGNGSTRYNALFFKDIFDKKQNFYKKKMSNIKNCGRDHDRLAEMAAFCGHISAQIPALADEWINDCSTHYPLSTFVMMLASKYAFSVPRLVAELLNNVFPTVMKKDQSILNLKSLFYFNIIFSSLTNLSVSGKGDYDCEPGVCLALHILVQLSCGTDEPFIMSEHYKGSNETIKLLPKCADEHMLSMIHWCEMDNVLFPMLSNICILLDTLRGRFKDLDLELSRIVDNTNYRREYLMIIVKSAQSIICEQDWVTMKMFRIVETKRMEAFNHDRLKQNCLGQQLLRLGIRRKSERDVVQELSVCNGNSKKALIDKLLSAMNLWNLRATLFDLMLMIKEVGYHYGEFLKIDAWLLSQQPFLNLVLACLKGEEYQPNKDGLVTSLYKQLQDLTLKTKEICQPQHSDGWSLLFFQMMLYGMVSLDKDRILYDSCYDMLSTLMLWTLTDPSTTTQLPTGENEAPKFRWPSYSQIIKRLKFDSNGLQKEIAEQHVSGELRALLQFLPIPKNTVDVLTVEPYGTLVVNPTQKTTRSPPNPPLLGVRHGRLALQPSEKAKVSSYDFIHGFVPEPNSKGGWKWSWFQASKLDRLPCPIQKWVSKLIIHKHHLDFQKPNMVIMESSSSDAFLSAPSVEASGEVPPITTTSTITPGTQTPATPTAPLIGSTDANTPVNEVEDTMPGSHTSANSAVSTPTTSEVPMGDTTPDQIRSISSVSNVIVSPRGGTRGGRKRGTNVNRQQSNHGRQKRSASRNDPPPTASGSASYNQGWQSGISQASSSQYMPQVTQPPPQSQQQQQQHQHQVPQTTHQVTGNHAVKAKIQMSITKRMEEKAAQGQMSAAFPGPSISQSSTMSGTTSQPTYSTDSGYIQQQNSNRNQSTISDKIAGASDFQAQQHGLSISSNSYPPGSGAQHMQSMQPLPQSQQQHPIQQHLQHSQQVAQQHPPQHPPQHPQQHPQQHPQQHPQQHPQQHPSQHPQQHPSQHPQQHPSQHPQQHPPQHPQQHPPQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQHPPQHTQQLSQQHTQQLSQQHTQQLSQQHTQQILQQTPQQQQMQQQQQQQMQQQQQQMQQQQQQQQIQQQQQQIQQQQQQLQQQQQQQQQQLQQQQQQQQLQQQQQQIQQQQQQQQQIQQQQQQQIQQQQQMQQQMQQQQLHQHLQPQIPQQLTQQIPHQHPQLLQHSQQQHQQPQARSHNVPQGGMVHQYNQSGALSSQPSMGGPPQMSYQGVAQQPRNTMGQFTSRDGIGMDYQSGGSRVNPPPLSLPQMHQNQPGIGMGSRSGVPTNQQSMTAQPHVGAQGQMSGHPQISGQQHITPNPQMIGQPSLSGHPSMGQSSMAAQQYPFMQPESRFVKFICTLSFFYMFPILCLILLSSRILF
Length2157
PositionKinase
OrganismHeterorhabditis bacteriophora (Entomopathogenic nematode)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Strongyloidea> Heterorhabditidae> Heterorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.669
Instability index57.43
Isoelectric point8.78
Molecular weight246687.96
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10583
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     453.30|      15|      15|    1732|    1746|       1
---------------------------------------------------------------------------
 1668- 1682 (39.37/10.27)	QHPPQHPPQHPQQHP
 1684- 1698 (42.08/11.48)	QHPQQHPQQHPQQHP
 1700- 1714 (39.06/10.13)	QHPQQHPSQHPQQHP
 1716- 1730 (40.99/10.99)	QHPQQHPPQHPQQHP
 1732- 1746 (42.08/11.48)	QHPQQHPQQHPQQHP
 1748- 1762 (42.08/11.48)	QHPQQHPQQHPQQHP
 1764- 1778 (42.08/11.48)	QHPQQHPQQHPQQHP
 1780- 1794 (42.08/11.48)	QHPQQHPQQHPQQHP
 1795- 1809 (29.85/ 6.03)	QHPPQHTQQLSQQHT
 1847- 1861 (32.33/ 7.14)	QQQQQQMQQQQQQQQ
 1863- 1877 (29.88/ 6.05)	QQQQQQIQQQQQQLQ
 1897- 1911 (31.44/ 6.74)	QQQQQQIQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.51|      21|      23|    2051|    2073|       2
---------------------------------------------------------------------------
 1823- 1843 (38.74/ 7.37)	QHTQQILQQTP.QQQQMQQQQQ
 2053- 2074 (32.77/ 8.78)	GIGMGSRSGVPtNQQSMTAQPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.99|      19|      23|    1923|    1945|       3
---------------------------------------------------------------------------
 1510- 1528 (37.12/ 8.03)	PQVTQPP..PQSQQQQQQHQH
 1919- 1939 (32.86/14.77)	QQIQQQQqmQQQMQQQQLHQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.09|      23|      23|    2081|    2103|       4
---------------------------------------------------------------------------
 1619- 1648 (29.58/ 7.45)	AQ..QHglsissnSY.PPGSGAQHM.QSMQPLPQ
 1946- 1971 (32.22/ 8.91)	QQltQQ.......IPhQHPQLLQHS.QQQHQQPQ
 2089- 2111 (30.29/ 7.84)	GQ..QH.......IT.PNPQMIGQPsLSGHPSM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.67|      20|      23|    1404|    1424|       5
---------------------------------------------------------------------------
 1371- 1386 (27.84/15.51)	TTTS....TITPGTQTPA.....TP
 1402- 1421 (26.18/19.77)	.EVE....DTMPGSHTSAnSAVSTP
 1422- 1443 (17.65/ 6.51)	TTSEvpmgDTTPDQIRSI.SSVS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      94.28|      16|      58|    1589|    1604|       9
---------------------------------------------------------------------------
 1453- 1467 (18.57/ 8.37)	.TRGGRKRGTNVNRQQ
 1468- 1481 (22.59/12.34)	S.NHGR.QKRSASRND
 1495- 1509 (23.61/13.34)	GWQSG.ISQASSSQYM
 1589- 1604 (29.52/19.19)	STDSGYIQQQNSNRNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.74|      19|      23|    1244|    1263|      10
---------------------------------------------------------------------------
 1244- 1263 (27.83/19.23)	LTVEpYGTLVVNPTQKTTRS
 1270- 1288 (31.92/16.98)	LGVR.HGRLALQPSEKAKVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.46|      10|     226|    1650|    1660|      11
---------------------------------------------------------------------------
 1650- 1660 (16.89/11.74)	QQQHPiQQHLQ
 1879- 1888 (19.57/ 8.29)	QQQQQ.QQQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.81|      23|      41|    1979|    2013|      12
---------------------------------------------------------------------------
 1987- 2013 (38.31/33.32)	NQSGALSSQPSMGgppqMSYQG....VAQQP
 2015- 2041 (38.50/10.46)	NTMGQFTSRDGIG....MDYQSggsrVNPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.91|      21|     132|    1174|    1199|      14
---------------------------------------------------------------------------
 1174- 1199 (35.81/29.23)	WTLTDPSTTTQLPtgeneAPKFRWPS
 1308- 1328 (43.10/23.54)	WSWFQASKLDRLP.....CPIQKWVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10583 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLSAPSVEASGEVPPITTTSTITPGTQTPATPTAPLIGSTDANTPVNEVEDTMPGSHTSANSAVSTPTTSEVPMGDTTPDQIRSISSVSNVIVSPRGGTRGGRKRGTNVNRQQSNHGRQKRSASRNDPPPTASGSASYNQGWQSGISQASSSQYMPQVTQPPPQSQQQQQQHQHQVPQTTHQVTGNHAVKAKIQMSITKRMEEKAAQGQMSAAFPGPSISQSSTMSGTTSQPTYSTDSGYIQQQNSNRNQSTISDKIAGASDFQAQQHGLSISSNSYPPGSGAQHMQSMQPLPQSQQQHPIQQHLQHSQQVAQQHPPQHPPQHPQQHPQQHPQQHPQQHPQQHPSQHPQQHPSQHPQQHPSQHPQQHPPQHPQQHPPQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQQHPQHPPQHTQQLSQQHTQQLSQQHTQQLSQQHTQQILQQTPQQ
2) MQQQQLHQHLQPQIPQQLTQQIPHQHPQLLQHSQQQHQQPQARSHNVPQGGMVHQYNQSGALSSQPSMGGPPQMSYQGVAQQPRNTMGQFTSRDGIGMDYQSGGSRVNPPPLSLPQMHQNQPGIGMGSRSGVPTNQQSMTAQPHVGAQGQMSGHPQISGQQHITPNPQMIGQPSLSGHPSMGQSSMAAQ
1355
1931
1835
2119










Molecular Recognition Features






MoRF SequenceStartStop




1) GKTSSVVTWYQSTADKRLLKKHKI
3
26